INT179168

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Context Info
Confidence 0.43
First Reported 2004
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.88
Pain Relevance 0.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (IL8) extracellular space (IL8) extracellular region (IL8)
intracellular (IL8)
Anatomy Link Frequency
Caco-2 2
IL8 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 130 98.60 Very High Very High Very High
cytokine 132 94.32 High High
Inflammatory response 14 69.68 Quite High
chemokine 23 38.68 Quite Low
Inflammatory mediators 24 5.00 Very Low Very Low Very Low
Catecholamine 16 5.00 Very Low Very Low Very Low
antagonist 11 5.00 Very Low Very Low Very Low
bradykinin 6 5.00 Very Low Very Low Very Low
metalloproteinase 5 5.00 Very Low Very Low Very Low
dexamethasone 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 24 98.88 Very High Very High Very High
INFLAMMATION 166 98.60 Very High Very High Very High
Otitis Media 134 98.24 Very High Very High Very High
Otitis Media With Effusion 92 97.48 Very High Very High Very High
Autoimmune Disease 1 93.92 High High
Sprains And Strains 26 92.40 High High
Adhesions 14 66.12 Quite High
Stress 16 50.00 Quite Low
Bacterial Infection 5 44.48 Quite Low
Infection 33 41.32 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In our measurements of IL8 mRNA levels in ten control participants, normalized versus EARs and versus NF, the IL8 mRNA levels with the two different approaches were similar in single human samples; also, again, the similar median value obtained (Figure 4b) confirmed the result.
Regulation (measurements) of Transcription (levels) of IL8
1) Confidence 0.43 Published 2010 Journal Genome Biol Section Body Doc Link PMC2847721 Disease Relevance 0.38 Pain Relevance 0.27
This suggests that after 2 h of co-incubation TTSS1 is not involved in IL-8 mRNA production by the Caco-2 cells, while TTSS2 is involved in the inhibition of the IL-8 transcription.
Neg (not) Regulation (involved) of Transcription (production) of IL-8 in Caco-2
2) Confidence 0.17 Published 2010 Journal BMC Microbiol Section Body Doc Link PMC3022711 Disease Relevance 0.24 Pain Relevance 0
activated IL-8 mRNA production but epinephrine had no effect on IL-8 transcripts.
Neg (no) Regulation (effect) of Transcription (transcripts) of IL-8
3) Confidence 0.04 Published 2004 Journal BMC Immunol Section Body Doc Link PMC521685 Disease Relevance 0 Pain Relevance 0.12
This delay of the IL-8 peak level suggests that IL-8 is produced by inflammatory cells which accumulated via the influence of TNF-?
Regulation (delay) of Transcription (level) of IL-8 associated with inflammation
4) Confidence 0.03 Published 2008 Journal Clinical and Experimental Otorhinolaryngology Section Body Doc Link PMC2671742 Disease Relevance 1.26 Pain Relevance 0.24

General Comments

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