INT179169

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Context Info
Confidence 0.15
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 11
Total Number 11
Disease Relevance 4.22
Pain Relevance 1.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (IL13) extracellular space (IL13) extracellular region (IL13)
cell-cell signaling (IL13) cytoplasm (IL13)
Anatomy Link Frequency
T cell 2
middle ear 1
blood 1
basophils 1
mast cells 1
IL13 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 308 100.00 Very High Very High Very High
Inflammation 86 91.76 High High
tolerance 4 86.52 High High
Osteoarthritis 54 73.68 Quite High
Etanercept 8 72.20 Quite High
chemokine 4 66.96 Quite High
endometriosis 1 55.08 Quite High
Inflammatory response 1 52.24 Quite High
antagonist 32 44.88 Quite Low
fibrosis 6 41.04 Quite Low
Disease Link Frequency Relevance Heat
Infection 126 99.34 Very High Very High Very High
Flavivirus Infection 7 99.08 Very High Very High Very High
Reprotox - General 3 27 99.00 Very High Very High Very High
Otitis Media With Effusion 39 95.72 Very High Very High Very High
Hyperplasia 2 92.08 High High
INFLAMMATION 86 91.76 High High
Metaplasia 1 91.60 High High
Chlamydia Infection 28 91.16 High High
Hypersensitivity 169 89.04 High High
Immunization 1 79.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
, IL-9, IL-10, IL-13, IL-17A, and IL-17F transcripts were quantitated on single CD4+ T cells.
Transcription (transcripts) of IL-13 in T cells
1) Confidence 0.15 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2806834 Disease Relevance 0 Pain Relevance 0
was a good inducer of IL-13 transcription while epinephrine alone only minimally induced IL-13 mRNA.
Transcription (transcription) of IL-13
2) Confidence 0.12 Published 2004 Journal BMC Immunol Section Body Doc Link PMC521685 Disease Relevance 0 Pain Relevance 0.10
and epinephrine significantly increased IL-13 mRNA production over that seen with each stimulus alone (Fig 4).
Transcription (production) of IL-13
3) Confidence 0.12 Published 2004 Journal BMC Immunol Section Body Doc Link PMC521685 Disease Relevance 0 Pain Relevance 0.07
To evaluate further the ability of epinephrine to induce IL-13 transcription at a molecular level, we transiently transfected HMC-1 cells with minimal promoter sequences as described in the materials and methods.
Transcription (transcription) of IL-13
4) Confidence 0.12 Published 2004 Journal BMC Immunol Section Body Doc Link PMC521685 Disease Relevance 0 Pain Relevance 0.08
Similarly, Smimova et al. (22) reported that the mucin content of effusions was correlated with the concentration of IL-4 and IL-13, suggesting the involvement of IL-4 and IL-13 in the upregulation of middle ear mucin metabolism.
Transcription (concentration) of IL-13 in middle ear
5) Confidence 0.11 Published 2010 Journal Clinical and Experimental Otorhinolaryngology Section Body Doc Link PMC2896736 Disease Relevance 1.02 Pain Relevance 0.09
IL-4 levels and IL-13 levels were below detection limits in non-stimulated serum as well as in ACS (Figure 5).


Transcription (levels) of IL-13
6) Confidence 0.10 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911907 Disease Relevance 0.32 Pain Relevance 0.44
A microarray study of whole blood gene expression during secondary DV infection has shown early upregulation of IL-13 transcripts in acute samples from DHF patients [12].
Transcription (transcripts) of IL-13 in blood associated with flavivirus infection and infection
7) Confidence 0.10 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2233670 Disease Relevance 0.72 Pain Relevance 0.04
Recent studies of in vitro rapid antigen desensitizations implicate mast cells and basophils as cellular targets, as well as syk, a signal transducing molecule, and signal transducer and activator of transcription 6 (STAT6), which is responsible for the transcription of interleukin (IL)-4 and IL-13.29 Rapid desensitization results in patients achieving the target total dose of the drug through rapidly escalating doses usually within 24 hours, slow desensitization results in patients achieving the total target dose within a few days to weeks.
Transcription (transcription) of IL-13 in basophils
8) Confidence 0.06 Published 2010 Journal Allergy, Asthma & Immunology Research Section Body Doc Link PMC2846744 Disease Relevance 0.60 Pain Relevance 0.04
The sequential events include induction of CD 80/86 on the B cell that engages CD28 on the T cell, leading to transcription of pivotal Th2 cytokines IL-4 and/or IL-13.
Transcription (transcription) of IL-13 in T cell associated with cytokine
9) Confidence 0.03 Published 2010 Journal Clin Mol Allergy Section Body Doc Link PMC2837605 Disease Relevance 0 Pain Relevance 0.17
In our study, IL-4 was undetectable and IL-13 levels were not significantly different in any group in contrast to previous report in which cHSP60 specific IL-13 in PBMCs has been reported to be associated with the protective response [22].
Transcription (undetectable) of IL-13
10) Confidence 0.03 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2412883 Disease Relevance 0.95 Pain Relevance 0.29
Recent studies of in vitro rapid antigen desensitizations implicate mast cells and basophils as cellular targets, as well as syk, a signal transducing molecule, and signal transducer and activator of transcription 6 (STAT6), which is responsible for the transcription of interleukin (IL)-4 and IL-13.29 Rapid desensitization results in patients achieving the target total dose of the drug through rapidly escalating doses usually within 24 hours, slow desensitization results in patients achieving the total target dose within a few days to weeks.
Transcription (transcription) of IL-13 in mast cells
11) Confidence 0.02 Published 2010 Journal Allergy, Asthma & Immunology Research Section Body Doc Link PMC2846744 Disease Relevance 0.60 Pain Relevance 0.04

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