INT179198

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Context Info
Confidence 0.25
First Reported 2004
Last Reported 2004
Negated 1
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 2.04
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (AGTR1) signal transducer activity (AGTR1)
Anatomy Link Frequency
plasma 2
AGTR1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammatory response 2 71.20 Quite High
Inflammation 66 50.00 Quite Low
ischemia 1 46.96 Quite Low
antagonist 9 5.00 Very Low Very Low Very Low
cytokine 8 5.00 Very Low Very Low Very Low
chemokine 5 5.00 Very Low Very Low Very Low
fibrosis 4 5.00 Very Low Very Low Very Low
cINOD 3 5.00 Very Low Very Low Very Low
Inflammatory mediators 3 5.00 Very Low Very Low Very Low
bradykinin 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypoxia 58 99.34 Very High Very High Very High
Apoptosis 2 94.08 High High
Hypertension 8 87.92 High High
Stress 11 76.64 Quite High
Disease 28 73.72 Quite High
INFLAMMATION 71 70.84 Quite High
Papillomavirus Infection 33 69.92 Quite High
Breast Cancer 3 61.28 Quite High
Cancer 91 57.04 Quite High
Increased Venous Pressure Under Development 8 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
governs many hypoxia driven transcriptions [43], its control of AT1b and AT2 expression can be hypothesized.
Regulation (control) of Gene_expression (expression) of AT1b associated with hypoxia
1) Confidence 0.25 Published 2004 Journal J Inflamm (Lond) Section Body Doc Link PMC1074345 Disease Relevance 1.19 Pain Relevance 0.04
The present results show that, in anaesthetized dogs, ACE inhibition or AT1 receptor blockade did not affect pulmonary vascular tone during increased FiO2 or in hypoxia, although measurements of plasma renin activity and angiotensin II immunoreactivity suggested activation of the rennin-angiotensin system during hypoxia and effective blockade of the renin-angiotensin cascade with enalaprilat and candesartan.
Neg (not) Regulation (affect) of Neg (inhibition) Gene_expression (inhibition) of AT1 in plasma associated with hypoxia
2) Confidence 0.07 Published 2004 Journal Crit Care Section Body Doc Link PMC522832 Disease Relevance 0.84 Pain Relevance 0

General Comments

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