INT179213

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.63
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 11
Disease Relevance 5.13
Pain Relevance 0.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Aqp3) transmembrane transport (Aqp3) cytoplasm (Aqp3)
Anatomy Link Frequency
brain 2
astrocytes 2
eye 1
epithelial cells 1
endothelium 1
Aqp3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
hyperexcitability 5 97.32 Very High Very High Very High
Hippocampus 8 89.40 High High
sodium channel 13 87.08 High High
ischemia 33 86.32 High High
agonist 58 81.68 Quite High
fibrosis 3 67.08 Quite High
corticosteroid 1 60.40 Quite High
Catecholamine 4 58.52 Quite High
Demyelination 3 56.56 Quite High
antagonist 6 43.92 Quite Low
Disease Link Frequency Relevance Heat
Chronic Renal Failure 124 99.44 Very High Very High Very High
Aging 6 99.00 Very High Very High Very High
Disorders Of The Lacrimal System 5 96.40 Very High Very High Very High
Ganglion Cysts 36 94.36 High High
Hypoxia 47 87.04 High High
Cv Unclassified Under Development 24 86.32 High High
Stress 64 84.48 Quite High
Neurological Disease 9 84.44 Quite High
Congenital Anomalies 9 80.44 Quite High
Nervous System Injury 5 76.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
While AQP1 is expressed by cornea endothelium, ciliary and lens epithelia, trabecular meshwork [15], pigment epithelial cells [16], rodent amacrine cells [17,18], and photoreceptor cells [19], AQP3 is detected in conjunctiva [20].
Gene_expression (detected) of AQP3 in epithelial cells
1) Confidence 0.63 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2831780 Disease Relevance 0.56 Pain Relevance 0.03
The same study reported that the human Müller cell line MIO-M1 [11] expressed mRNA for AQP0, AQP1, AQP3, AQP4, AQP5, AQP7, AQP8, AQP9, AQP10, and AQP11 but not AQP2, AQP6, and AQP12 [10].
Gene_expression (expressed) of AQP3
2) Confidence 0.49 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2831780 Disease Relevance 0.62 Pain Relevance 0
In the previous study (7), we found a marked reduction in the expression of two collecting duct water channels AQP2 and AQP3 in rats with CRF, indicating a defect in collecting duct water reabsorption.
Gene_expression (expression) of AQP3 in duct associated with chronic renal failure
3) Confidence 0.47 Published 2005 Journal Journal of Korean Medical Science Section Body Doc Link PMC2808601 Disease Relevance 0.31 Pain Relevance 0
In addition, the expression of several aquaporins including AQP1, AQP2, AQP3, and AQP5 decrease with aging [49–51], and therefore AQP4 expression may also decrease with aging.
Gene_expression (expression) of AQP3 associated with aging
4) Confidence 0.42 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2559817 Disease Relevance 0.20 Pain Relevance 0.05
In addition, the expression of several aquaporins including AQP1, AQP2, AQP3, and AQP5 decrease with aging [49–51], and therefore AQP4 expression may also decrease with aging.
Gene_expression (expression) of AQP3 associated with aging
5) Confidence 0.37 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2559817 Disease Relevance 0.20 Pain Relevance 0.05
AQP1 is expressed in microvascular endothelium, while AQP3 and AQP4 are expressed in large airways.
Gene_expression (expressed) of AQP3 in endothelium
6) Confidence 0.35 Published 2004 Journal Crit Care Section Body Doc Link PMC522843 Disease Relevance 0.64 Pain Relevance 0.27
At least six AQPs are expressed in the eye: AQP0 major intrinsic protein (MIP) in lens fiber; AQP1 in cornea endothelium, ciliary and lens epithelia, trabecular meshwork, and retinal photoreceptor cells; AQP3 in conjunctiva; AQP4 in ciliary epithelium and retinal Muller cells; AQP5 in corneal and lacrimal gland epithelia [18]; and AQP9 in retinal ganglion cells [19].
Gene_expression (expressed) of AQP3 in eye associated with ganglion cysts and disorders of the lacrimal system
7) Confidence 0.33 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2559817 Disease Relevance 1.61 Pain Relevance 0.07
AQP3, 5, and 8 expression was detected in whole rat brain and astrocytes via reverse transcription–polymerase chain reaction.
Gene_expression (expression) of AQP3 in brain
8) Confidence 0.32 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2647147 Disease Relevance 0.25 Pain Relevance 0.07
AQP3, 5, and 8 expression was detected in whole rat brain and astrocytes via reverse transcription–polymerase chain reaction.
Gene_expression (detected) of AQP3 in brain
9) Confidence 0.25 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2647147 Disease Relevance 0.25 Pain Relevance 0.07
AQP3, 5, and 8 expression was detected in whole rat brain and astrocytes via reverse transcription–polymerase chain reaction.
Gene_expression (expression) of AQP3 in astrocytes
10) Confidence 0.11 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2647147 Disease Relevance 0.25 Pain Relevance 0.07
AQP3, 5, and 8 expression was detected in whole rat brain and astrocytes via reverse transcription–polymerase chain reaction.
Gene_expression (detected) of AQP3 in astrocytes
11) Confidence 0.08 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2647147 Disease Relevance 0.25 Pain Relevance 0.07

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox