INT179225

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Context Info
Confidence 0.43
First Reported 2004
Last Reported 2008
Negated 0
Speculated 1
Reported most in Body
Documents 10
Total Number 12
Disease Relevance 9.62
Pain Relevance 2.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (AMIGO2) plasma membrane (AMIGO2) nucleus (AMIGO2)
Anatomy Link Frequency
lung 2
blood 1
neutrophil 1
AMIGO2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 120 100.00 Very High Very High Very High
agonist 174 99.78 Very High Very High Very High
Pain 1 96.44 Very High Very High Very High
cytokine 39 95.52 Very High Very High Very High
Inflammatory mediators 9 88.12 High High
ischemia 12 84.56 Quite High
Dopamine 3 73.28 Quite High
sodium channel 39 71.44 Quite High
anesthesia 8 53.76 Quite High
Inflammatory marker 6 53.00 Quite High
Disease Link Frequency Relevance Heat
Adult Respiratory Distress Syndrome 457 100.00 Very High Very High Very High
INFLAMMATION 155 100.00 Very High Very High Very High
Pressure And Volume Under Development 141 100.00 Very High Very High Very High
Sepsis 87 99.32 Very High Very High Very High
Injury 34 97.00 Very High Very High Very High
Pain 1 96.44 Very High Very High Very High
Lung Injury 144 96.40 Very High Very High Very High
Pneumonia 7 90.80 High High
Stroke 29 90.64 High High
Shock 6 89.92 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Munira followed Ali from near the premises of the main dealer, asking him to inject her in a ruined house nearby by the light of a candle.
Positive_regulation (followed) of Ali
1) Confidence 0.43 Published 2005 Journal Harm Reduct J Section Body Doc Link PMC1236949 Disease Relevance 0.10 Pain Relevance 0.10
Several different beta agonists have been shown to increase alveolar edema clearance in several different models of ALI.
Positive_regulation (increase) of ALI associated with pressure and volume under development, agonist and adult respiratory distress syndrome
2) Confidence 0.08 Published 2004 Journal Crit Care Section Body Doc Link PMC522843 Disease Relevance 0.93 Pain Relevance 0.37
First, if inhaled beta-2 agonists are to be effective for edema clearance in ALI, then there must be therapeutic levels in the alveolae.
Positive_regulation (effective) of ALI associated with pressure and volume under development, agonist and adult respiratory distress syndrome
3) Confidence 0.08 Published 2004 Journal Crit Care Section Body Doc Link PMC522843 Disease Relevance 1.35 Pain Relevance 0.30
For example, inhaled beta-2 adrenergic agonists are used to decrease airway resistance when it is increased in ALI and ARDS.
Positive_regulation (increased) of ALI associated with agonist and adult respiratory distress syndrome
4) Confidence 0.08 Published 2004 Journal Crit Care Section Body Doc Link PMC522843 Disease Relevance 1.56 Pain Relevance 0.29
OA may also promote ALI by increasing the ratio between angiotensin-converting enzymes I and II [47], upregulating inducible nitric-oxide synthase (iNOS), and inhibiting alveolar epithelial Na,K-ATPase activity [48].
Spec (may) Positive_regulation (promote) of ALI associated with adult respiratory distress syndrome
5) Confidence 0.05 Published 2008 Journal Crit Care Section Body Doc Link PMC2646309 Disease Relevance 0.96 Pain Relevance 0.16
However, in OA-induced ALI, neutrophil depletion does not seem to significantly affect the course of injury [37].
Positive_regulation (induced) of ALI in neutrophil associated with injury and adult respiratory distress syndrome
6) Confidence 0.05 Published 2008 Journal Crit Care Section Body Doc Link PMC2646309 Disease Relevance 1.25 Pain Relevance 0.22
Our aim was to find out whether rhAPC dampens OA-induced ALI in sheep.


Positive_regulation (induced) of ALI associated with adult respiratory distress syndrome
7) Confidence 0.04 Published 2008 Journal Crit Care Section Abstract Doc Link PMC2646309 Disease Relevance 0.71 Pain Relevance 0.04
Our aim was to investigate the effects of rhAPC on sustained LPS-induced ALI in sheep over 24 hours by assessing changes in pulmonary hemodynamics, in extravascular lung water content, in pulmonary vascular permeability index and in gas exchange.
Positive_regulation (induced) of ALI in lung associated with adult respiratory distress syndrome
8) Confidence 0.04 Published 2008 Journal Crit Care Section Body Doc Link PMC2575593 Disease Relevance 0.73 Pain Relevance 0.22
Recent research has revealed that thrombin, a blood coagulation protease, is a key trigger of both the coagulation and the inflammation system in ALI [8].
Positive_regulation (trigger) of ALI in blood associated with inflammation and adult respiratory distress syndrome
9) Confidence 0.03 Published 2008 Journal Crit Care Section Body Doc Link PMC2575593 Disease Relevance 0.84 Pain Relevance 0.20
Further studies are warranted to determine whether these beneficial effects also apply in patients suffering from sepsis – and in patients from nonsepsis-induced ALI.


Positive_regulation (induced) of ALI associated with adult respiratory distress syndrome and sepsis
10) Confidence 0.03 Published 2008 Journal Crit Care Section Body Doc Link PMC2575593 Disease Relevance 0.74 Pain Relevance 0.15
Since an increase in pleural pressure in ALI is correlated with lung volume but not with airway pressure (35), the increased lung volume associated with PEEPDEF may have increased pleural pressure, thereby hindering venous return, which decreases venous flow, right ventricular stroke volume, and consequently cardiac output (36).
Positive_regulation (increase) of ALI in lung associated with stroke and adult respiratory distress syndrome
11) Confidence 0.01 Published 2007 Journal Journal of Korean Medical Science Section Body Doc Link PMC2693641 Disease Relevance 0.19 Pain Relevance 0
ALI was induced by infusion of oleic acid, using a modification of method used by Suh et al. (17).
Positive_regulation (induced) of ALI associated with adult respiratory distress syndrome
12) Confidence 0.01 Published 2007 Journal Journal of Korean Medical Science Section Body Doc Link PMC2693641 Disease Relevance 0.27 Pain Relevance 0

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