INT17924

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Context Info
Confidence 0.56
First Reported 1988
Last Reported 2008
Negated 1
Speculated 0
Reported most in Abstract
Documents 7
Total Number 7
Disease Relevance 0.65
Pain Relevance 3.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Calcb)
Anatomy Link Frequency
Sensory neurons 1
autonomic neurons 1
enteric nerves 1
intestines 1
Calcb (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Calcitonin gene-related peptide 99 100.00 Very High Very High Very High
Opioid 2 100.00 Very High Very High Very High
Neuropeptide 17 99.74 Very High Very High Very High
qutenza 9 99.74 Very High Very High Very High
gABA 6 94.40 High High
dexamethasone 3 88.04 High High
Spinal cord 39 87.32 High High
Serotonin 3 70.72 Quite High
calcitonin gene related peptide 1 50.20 Quite High
Dynorphin 1 42.40 Quite Low
Disease Link Frequency Relevance Heat
Diabetes Mellitus 8 99.68 Very High Very High Very High
Hyperphagia 1 78.32 Quite High
Weight Gain 1 76.40 Quite High
Body Weight 1 71.84 Quite High
Aids-related Complex 7 64.96 Quite High
Frailty 3 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Adhesions 1 5.00 Very Low Very Low Very Low
Nociception 1 5.00 Very Low Very Low Very Low
Disease 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Sensory neurons and enteric neurons have been identified as populations which preferentially express alpha-CGRP and beta-CGRP, respectively.
Gene_expression (express) of beta-CGRP in Sensory neurons associated with calcitonin gene-related peptide
1) Confidence 0.56 Published 1988 Journal Neuroscience Section Abstract Doc Link 2839796 Disease Relevance 0 Pain Relevance 0.82
Differential expression of alpha-CGRP and beta-CGRP by primary sensory neurons and enteric autonomic neurons of the rat.
Gene_expression (expression) of beta-CGRP in autonomic neurons associated with qutenza
2) Confidence 0.56 Published 1988 Journal Neuroscience Section Title Doc Link 2839796 Disease Relevance 0 Pain Relevance 0.98
Expression of the calcitonin gene-related peptide, alpha-calcitonin gene-related peptide (CGRP), and the homologous beta-CGRP were compared in sensory and enteric nerves of the rat.
Gene_expression (Expression) of beta-CGRP in enteric nerves associated with calcitonin gene-related peptide
3) Confidence 0.56 Published 1988 Journal Neuroscience Section Abstract Doc Link 2839796 Disease Relevance 0 Pain Relevance 0.55
Ox2r (orexin receptor 2), Calcb (calcitonin gene-related peptide) and Nefl (neurofilament light chain) were not expected a priori to be DE and were chosen for validation to make sure they were not false positives.
Neg (not) Gene_expression (expected) of Calcb associated with calcitonin gene-related peptide
4) Confidence 0.52 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2566599 Disease Relevance 0 Pain Relevance 0.13
Only beta-CGRP was detected in the intestines of capsaicin-treated rats.
Gene_expression (detected) of beta-CGRP in intestines associated with qutenza and calcitonin gene-related peptide
5) Confidence 0.44 Published 1988 Journal Neuroscience Section Abstract Doc Link 2839796 Disease Relevance 0 Pain Relevance 0.93
Immunoreactive NPY and its mRNA were detected in two cultured beta-cell lines, HIT T-15 and RIN m5F cells whereas VIP and beta-CGRP were undetectable.
Gene_expression (undetectable) of beta-CGRP
6) Confidence 0.41 Published 1991 Journal Endocrinology Section Abstract Doc Link 1954911 Disease Relevance 0 Pain Relevance 0.35
Effects of streptozotocin (STZ)-induced diabetes and insulin on opioid peptide gene expression were examined in rats.
Gene_expression (expression) of opioid peptide gene associated with diabetes mellitus and opioid
7) Confidence 0.03 Published 1999 Journal Am. J. Physiol. Section Abstract Doc Link 10233022 Disease Relevance 0.65 Pain Relevance 0.10

General Comments

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