INT17925

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Context Info
Confidence 0.72
First Reported 1991
Last Reported 2010
Negated 0
Speculated 2
Reported most in Abstract
Documents 53
Total Number 56
Disease Relevance 15.75
Pain Relevance 25.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Npy) extracellular region (Npy)
Anatomy Link Frequency
arcuate nucleus 7
neurons 4
dorsal root ganglia 4
dentate gyrus 3
brain 3
Npy (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Neuropeptide 143 100.00 Very High Very High Very High
Inflammation 50 100.00 Very High Very High Very High
Enkephalin 21 100.00 Very High Very High Very High
antidepressant 40 99.80 Very High Very High Very High
Opioid 5 99.80 Very High Very High Very High
antagonist 14 99.60 Very High Very High Very High
spinal dorsal horn 20 99.20 Very High Very High Very High
projection neuron 3 99.18 Very High Very High Very High
Spinal cord 36 99.08 Very High Very High Very High
dexamethasone 19 99.06 Very High Very High Very High
Disease Link Frequency Relevance Heat
Aids-related Complex 124 100.00 Very High Very High Very High
Sprains And Strains 33 99.26 Very High Very High Very High
Depression 41 98.60 Very High Very High Very High
Hypoxia 1 98.36 Very High Very High Very High
Anorexia 12 98.04 Very High Very High Very High
Stress 19 97.96 Very High Very High Very High
Infarction 1 97.20 Very High Very High Very High
Hyperinsulinism 3 96.84 Very High Very High Very High
INFLAMMATION 40 96.52 Very High Very High Very High
Middle Cerebral Artery Infarction 3 96.52 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, our data demonstrate stimulatory action of ghrelin on NPY gene transcription, which requires de novo protein synthesis.
Transcription (transcription) of NPY gene
1) Confidence 0.72 Published 2006 Journal Endocrinology Section Abstract Doc Link 16887908 Disease Relevance 0 Pain Relevance 0.26
Experiments in vivo also demonstrated that increases in GAD65 mRNA expression in the arcuate nucleus preceded decreases in the NPY mRNA expression in a fasting-refeeding paradigm and that intracerebroventricular injection of insulin increased GAD65 mRNA expression in the arcuate nucleus in fasted rats.
Transcription (expression) of NPY in arcuate nucleus associated with hyperinsulinism and intracerebroventricular
2) Confidence 0.69 Published 2005 Journal J. Neurosci. Section Abstract Doc Link 16177033 Disease Relevance 0.10 Pain Relevance 0.81
Pharmacological experiments using selective Y1 and Y2 receptor antagonists suggest that Y2 is the prominent NPY receptor subtype expressed in trigeminal ganglia neurons, DRG neurons, and spinal cord.
Transcription (expressed) of NPY in neurons associated with antagonist and spinal cord
3) Confidence 0.68 Published 1994 Journal J. Neurosci. Section Abstract Doc Link 8207499 Disease Relevance 0.31 Pain Relevance 0.67
Furthermore, the number of c-Fos-LI cells as well as the percentage of c-Fos-LI cuneothalamic projection neurons (CTNs) in the CN was markedly decreased after injection of NPY receptor antagonist along with retrograde tract-tracing method, indicating that NPY regulated c-Fos expression.
Transcription (injection) of NPY in CTNs associated with antagonist and projection neuron
4) Confidence 0.67 Published 2009 Journal J. Neurotrauma Section Abstract Doc Link 19456245 Disease Relevance 0.59 Pain Relevance 0.56
In this tissue, mRNA of Y2 and Y4 NPY receptor subtypes were highly expressed, whereas Y5 mRNA levels were very low and Y1 mRNA levels were intermediate.
Transcription (expressed) of NPY
5) Confidence 0.65 Published 1998 Journal Regul. Pept. Section Abstract Doc Link 9802413 Disease Relevance 0 Pain Relevance 0.15
The divergent effects of imipramine vs the other 3 antidepressant drugs on Arc NPY mRNA expression are similar to the pattern of changes in tyrosine hydroxylase (TH) mRNA expression levels in the locus coeruleus (LC) using the same experimental paradigm, but are different from the unidirectional depressive effects of all four drugs on CRH mRNA expression in the PVN.
Transcription (expression) of Arc NPY in PVN associated with antidepressant, depression, aids-related complex and locus ceruleus
6) Confidence 0.62 Published 1996 Journal J. Neuroendocrinol. Section Abstract Doc Link 8736433 Disease Relevance 0.66 Pain Relevance 0.65
The results demonstrate a good correlation between NPY peptide and mRNA expression, and sustain the possible involvement of NPY and Y1 receptors in depression.
Transcription (expression) of NPY associated with depression
7) Confidence 0.53 Published 1999 Journal Neurosci. Lett. Section Abstract Doc Link 10327163 Disease Relevance 0.34 Pain Relevance 0.38
Effects of long-term treatment with antidepressant drugs on proopiomelanocortin and neuropeptide Y mRNA expression in the hypothalamic arcuate nucleus of rats.
Transcription (expression) of neuropeptide Y in arcuate nucleus associated with antidepressant and neuropeptide
8) Confidence 0.53 Published 1996 Journal J. Neuroendocrinol. Section Title Doc Link 8736433 Disease Relevance 0.35 Pain Relevance 0.35
In the pair-fed group, NPY mRNA levels did not change, but the POMC levels decreased (compared with the vehicle controls).
Transcription (levels) of NPY
9) Confidence 0.53 Published 2005 Journal Arch. Pharm. Res. Section Abstract Doc Link 16042082 Disease Relevance 0.67 Pain Relevance 0.93
We examined mRNA expression levels of neuropeptide Y (NPY) and proopiomelanocortin (POMC) in the brain regions of rats using RT-PCR and in situ hybridization techniques after 2 weeks of administering fluoxetine daily.
Spec (examined) Transcription (expression) of NPY in brain associated with neuropeptide and fluoxetine
10) Confidence 0.53 Published 2005 Journal Arch. Pharm. Res. Section Abstract Doc Link 16042082 Disease Relevance 0.52 Pain Relevance 0.67
We examined mRNA expression levels of neuropeptide Y (NPY) and proopiomelanocortin (POMC) in the brain regions of rats using RT-PCR and in situ hybridization techniques after 2 weeks of administering fluoxetine daily.
Spec (examined) Transcription (expression) of neuropeptide Y in brain associated with neuropeptide and fluoxetine
11) Confidence 0.53 Published 2005 Journal Arch. Pharm. Res. Section Abstract Doc Link 16042082 Disease Relevance 0.52 Pain Relevance 0.67
Drinking of saccharin in turn elevated the mRNA levels of orexin and NPY, but not MCH.
Transcription (levels) of NPY
12) Confidence 0.52 Published 2006 Journal Behav. Brain Res. Section Abstract Doc Link 17010451 Disease Relevance 0.08 Pain Relevance 0.50
The glucagon-like peptide-I-(7-36) amide (GLP-1), a known gluco-incretin in humans, induced at low concentration (10(-9) M) a similar expression of NPY mRNA and peptide secretion in INS-1 cells.
Transcription (expression) of NPY
13) Confidence 0.52 Published 1993 Journal Endocrinology Section Abstract Doc Link 8396008 Disease Relevance 0.16 Pain Relevance 0.20
Dexamethasone (DEX) (10(-9) to 10(-7) M) significantly increased NPY mRNA expression, and the effects were not influenced by coincubation with the sodium channel blocker tetrodotoxin (TTX), indicating that the action of DEX is independent of action potentials.
Transcription (expression) of NPY associated with action potential, tetrodotoxin, sodium channel and dexamethasone
14) Confidence 0.52 Published 2005 Journal J. Neurosci. Section Abstract Doc Link 16177033 Disease Relevance 0 Pain Relevance 0.79
Furthermore, increases in the GABA-synthesizing enzyme glutamic acid decarboxylase 65 (GAD65) mRNA expression preceded decreases in NPY mRNA expression in the arcuate nucleus in the cultures.
Transcription (expression) of NPY in arcuate nucleus associated with gaba
15) Confidence 0.52 Published 2005 Journal J. Neurosci. Section Abstract Doc Link 16177033 Disease Relevance 0.08 Pain Relevance 0.86
Using in situ hybridization histochemistry neuropeptide Y (NPY) mRNA expression was investigated after intraperitoneal injection of kainic acid (KA) and after local application of KA or quinolinic acid into the dentate gyrus of the rat.
Transcription (expression) of neuropeptide Y in dentate gyrus associated with neuropeptide
16) Confidence 0.52 Published 1994 Journal Hippocampus Section Abstract Doc Link 7874238 Disease Relevance 0.20 Pain Relevance 0.05
Expression of neuropeptide Y and neuropeptide Y (Y1) receptor mRNA in rat spinal cord and dorsal root ganglia following peripheral tissue inflammation.
Transcription (Expression) of neuropeptide Y in spinal cord associated with inflammation, neuropeptide and spinal cord
17) Confidence 0.52 Published 1994 Journal J. Neurosci. Section Title Doc Link 7965047 Disease Relevance 0.16 Pain Relevance 0.58
This treatment increased mRNA steady-state levels of enkephalin, neuropeptide Y and chromogranin B 2-6-fold.
Transcription (levels) of neuropeptide Y associated with neuropeptide and enkephalin
18) Confidence 0.52 Published 1997 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9427505 Disease Relevance 0.24 Pain Relevance 0.49
Furthermore, a marked upregulation of NPY (Y1) receptor mRNA expression was detected in the ipsilateral spinal dorsal horn 1 d and 3 d after inoculation.
Transcription (expression) of Y1 in dorsal horn associated with spinal dorsal horn
19) Confidence 0.52 Published 1994 Journal J. Neurosci. Section Abstract Doc Link 7965047 Disease Relevance 0.16 Pain Relevance 0.58
Expression of neuropeptide Y and neuropeptide Y (Y1) receptor mRNA in rat spinal cord and dorsal root ganglia following peripheral tissue inflammation.
Transcription (Expression) of neuropeptide Y in spinal cord associated with inflammation, neuropeptide and spinal cord
20) Confidence 0.52 Published 1994 Journal J. Neurosci. Section Title Doc Link 7965047 Disease Relevance 0.16 Pain Relevance 0.57

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