INT179250

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.56
First Reported 2004
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 1.70
Pain Relevance 0.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (GSR) mitochondrion (GSR) small molecule metabolic process (GSR)
oxidoreductase activity (GSR) cytoplasm (GSR)
Anatomy Link Frequency
nucleus 2
blood cells 2
GSR (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 11 97.60 Very High Very High Very High
Inflammation 17 72.84 Quite High
dexamethasone 11 54.84 Quite High
rheumatoid arthritis 1 51.20 Quite High
depression 6 34.16 Quite Low
cva 5 5.00 Very Low Very Low Very Low
sSRI 4 5.00 Very Low Very Low Very Low
opiate 3 5.00 Very Low Very Low Very Low
medulla 3 5.00 Very Low Very Low Very Low
agonist 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Manic Depressive Disorder 22 96.20 Very High Very High Very High
Affective Disorder 48 94.68 High High
Depression 12 94.68 High High
Sepsis 33 79.20 Quite High
Mental Disorders 4 73.36 Quite High
INFLAMMATION 19 72.84 Quite High
Injury 41 71.24 Quite High
Congenital Anomalies 4 69.36 Quite High
Post-traumatic Stress Disorder 6 53.56 Quite High
Adult Respiratory Distress Syndrome 1 52.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Matsubara and colleagues recently found evidence of reduced mRNA expression of GR-alpha (the GR isoform which binds glucocorticoids) in peripheral blood cells of patients with bipolar disorder and in patients with major depressive disorder, both while depressed as well as in remission.
Negative_regulation (reduced) of Transcription (expression) of GR in blood cells associated with depression and manic depressive disorder
1) Confidence 0.56 Published 2007 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2656301 Disease Relevance 0.88 Pain Relevance 0.03
A post-mortem study of bipolar patients showed decreased expression of GR mRNA (Perlman et al 2004; Webster et al 2002) and an exaggerated responses to the dex/CRH test in healthy first degree relatives of mood disorder patients has been found (Lauer et al 1998).
Negative_regulation (decreased) of Transcription (expression) of GR associated with affective disorder
2) Confidence 0.41 Published 2007 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2656301 Disease Relevance 0.34 Pain Relevance 0
Potential mechanisms for cytokine-induced reduction in GR function and affinity may include inhibition of GR translocation from cytoplasm to nucleus and reduction in GR-mediated gene transcription [68].
Negative_regulation (reduction) of Transcription (transcription) of GR-mediated in nucleus associated with cytokine
3) Confidence 0.24 Published 2004 Journal Crit Care Section Body Doc Link PMC522845 Disease Relevance 0.48 Pain Relevance 0.15

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox