INT179257

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Context Info
Confidence 0.10
First Reported 2004
Last Reported 2008
Negated 0
Speculated 1
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 2.09
Pain Relevance 1.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (SERPINA6) extracellular space (SERPINA6) extracellular region (SERPINA6)
Anatomy Link Frequency
adrenal glands 2
plasma 1
capillary 1
SERPINA6 (Homo sapiens)
Pain Link Frequency Relevance Heat
corticosteroid 103 100.00 Very High Very High Very High
Serotonin 3 94.60 High High
Inflammation 53 91.44 High High
cytokine 33 83.36 Quite High
Pain 66 73.92 Quite High
Arthritis 4 72.24 Quite High
rheumatoid arthritis 5 26.08 Quite Low
Osteoarthritis 2 25.12 Quite Low
medulla 9 18.20 Low Low
local anesthetic 22 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Frailty 5 99.78 Very High Very High Very High
INFLAMMATION 59 91.44 High High
Necrosis 15 74.16 Quite High
Pain 47 73.92 Quite High
Cancer 8 73.80 Quite High
Arthritis 7 72.24 Quite High
Sepsis 101 71.28 Quite High
Hematoma 1 66.88 Quite High
Osteoarthritis 5 60.88 Quite High
Adrenal Insufficiency 15 57.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Under normal conditions, 90–95% of plasma cortisol in humans is bound to CBG, and it is generally accepted that the CBG-bound cortisol has restricted access to target cells [6,7].
CBG Binding (bound) of in plasma
1) Confidence 0.10 Published 2004 Journal Crit Care Section Body Doc Link PMC522845 Disease Relevance 0.36 Pain Relevance 0.22
Subsequently, ACTH increases cortisol release from the adrenal glands, which then binds to a specific carrier – cortisol-binding globulin (CBG) – that is synthetized by the liver and to albumin in order to reach the target tissues.
CBG Binding (binds) of in adrenal glands
2) Confidence 0.10 Published 2004 Journal Crit Care Section Body Doc Link PMC522845 Disease Relevance 0.55 Pain Relevance 0.24
Subsequently, ACTH increases cortisol release from the adrenal glands, which then binds to a specific carrier – cortisol-binding globulin (CBG) – that is synthetized by the liver and to albumin in order to reach the target tissues.
cortisol-binding globulin Binding (binds) of in adrenal glands
3) Confidence 0.08 Published 2004 Journal Crit Care Section Body Doc Link PMC522845 Disease Relevance 0.55 Pain Relevance 0.24
For example, it would be interesting to determine if this trend in trigger points reflects clinical experience that these rheumatologists might have with subcutaneous atrophy caused by injecting corticosteroid injections.
corticosteroid Spec (might) Binding (injecting) of associated with corticosteroid and frailty
4) Confidence 0.07 Published 2007 Journal BMC Musculoskelet Disord Section Body Doc Link PMC1950874 Disease Relevance 0.23 Pain Relevance 0.16
For many years, clinicians have been looking for alternatives to ABG sampling in both children and adults, and studies have investigated ABG, VBG, and capillary (CBG) blood gas samples and the correlation between the values.[15–17]
CBG Binding (investigated) of in capillary
5) Confidence 0.05 Published 2008 Journal Indian Journal of Critical Care Medicine : Peer-reviewed, Official Publication of Indian Society of Critical Care Medicine Section Body Doc Link PMC2738313 Disease Relevance 0.17 Pain Relevance 0.07
One participant was very upset because of negative experiences following the injection and another insisted that he had not participated in the study ("They just went with the corticosteroid with me, I never had the option of the other on").
corticosteroid Binding (went) of associated with corticosteroid
6) Confidence 0.04 Published 2005 Journal BMC Health Serv Res Section Body Doc Link PMC1112594 Disease Relevance 0.22 Pain Relevance 0.31

General Comments

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