INT179260

Context Info Confidence 0.27 First Reported 2004 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 2 Disease Relevance 1.80 Pain Relevance 0.15

nucleoplasm (AKT2) transport (AKT2) mitochondrion (AKT2) carbohydrate metabolic process (AKT2) cytoplasm (AKT2) cytosol (AKT2)

AKT2 (Homo sapiens)

Pain Link Frequency Relevance Heat Inflammation 27 94.24 Kinase C 1 69.20 cytokine 14 54.00 chemokine 100 50.00 Inflammatory response 2 49.48 Catecholamine 2 32.40 alcohol 1 32.00 antagonist 10 5.00 Central nervous system 5 5.00 cva 5 5.00

Disease Link Frequency Relevance Heat Ovarian Cancer 85 99.76 Brain Hemorrhage 1 99.24 Vasculitis 1 94.60 Myocardial Infarction 1 93.24 Cv Unclassified Under Development 1 91.88 Reperfusion Injury 1 91.48 Cancer 158 90.96 Apoptosis 4 89.68 INFLAMMATION 32 78.84 Carcinoma 2 76.32

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

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Disease term

, FGF1, MYC, EGFR, KRAS, HER2, and AKT2, have been also associated with ovarian cancer [56].

AKT2 Binding (associated) of associated with ovarian cancer

1) Confidence 0.27 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2798669 Disease Relevance 1.10 Pain Relevance 0

Similarly, binding of glucocorticoids to the GR-stimulated phosphatidylinositol 3-kinase and protein kinase Akt, leading to endothelial NOS activation and nitric oxide dependent vasorelaxation, is the mechanism by which glucocorticoids decreased vascular inflammation and reduced myocardial infarct size following ischaemia/reperfusion injury in mice [103].

protein kinase Akt Binding (binding) of associated with reperfusion injury, inflammation, cv unclassified under development, vasculitis and myocardial infarction

2) Confidence 0.03 Published 2004 Journal Crit Care Section Body Doc Link PMC522845 Disease Relevance 0.70 Pain Relevance 0.15

General Comments

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