INT179261

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Context Info
Confidence 0.14
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 12
Total Number 13
Disease Relevance 3.53
Pain Relevance 3.82

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (SERPINA6) extracellular space (SERPINA6) extracellular region (SERPINA6)
Anatomy Link Frequency
liver 2
blood 1
tendon 1
facet 1
knee 1
SERPINA6 (Homo sapiens)
Pain Link Frequency Relevance Heat
corticosteroid 550 100.00 Very High Very High Very High
local anesthetic 132 100.00 Very High Very High Very High
dexamethasone 12 97.68 Very High Very High Very High
Osteoarthritis 12 97.12 Very High Very High Very High
imagery 32 96.72 Very High Very High Very High
Nucleus accumbens 16 93.52 High High
Serotonin 4 93.40 High High
Pain 152 91.60 High High
Inflammation 80 89.12 High High
cytokine 44 82.16 Quite High
Disease Link Frequency Relevance Heat
Ketoacidosis 2 99.84 Very High Very High Very High
Osteoarthritis 30 97.12 Very High Very High Very High
Arthritis 42 90.56 High High
INFLAMMATION 88 89.12 High High
Sepsis 134 88.56 High High
Confusion 6 88.24 High High
Injury 11 87.20 High High
Arthropathy 12 86.32 High High
Burns 4 86.32 High High
Pain 61 74.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Subsequently, ACTH increases cortisol release from the adrenal glands, which then binds to a specific carrier – cortisol-binding globulin (CBG) – that is synthetized by the liver and to albumin in order to reach the target tissues.
Gene_expression (synthetized) of CBG in liver
1) Confidence 0.14 Published 2004 Journal Crit Care Section Body Doc Link PMC522845 Disease Relevance 0.54 Pain Relevance 0.23
In addition, CBG levels inversely correlated with the cortisol disappearance rate, suggesting that CBG actively modulates the disposition of cortisol in humans [44].
Gene_expression (levels) of CBG
2) Confidence 0.14 Published 2004 Journal Crit Care Section Body Doc Link PMC522845 Disease Relevance 0.41 Pain Relevance 0.12
Indeed, in dexamethasone-suppressed adults, cortisol concentrations correlated with exogenous cortisol infusion rate only when adjusted for CBG levels [44].
Gene_expression (levels) of CBG associated with dexamethasone
3) Confidence 0.14 Published 2004 Journal Crit Care Section Body Doc Link PMC522845 Disease Relevance 0.41 Pain Relevance 0.13
Analysis of each of the three physician groups yielded similar results for: 1) the orthopaedists for corticosteroid and local anesthetic injections (the absolute values of all ten r values are ?
Gene_expression (injections) of corticosteroid associated with corticosteroid and local anesthetic
4) Confidence 0.13 Published 2007 Journal BMC Musculoskelet Disord Section Body Doc Link PMC1950874 Disease Relevance 0 Pain Relevance 0.71
This lack of uniform injection guidelines is important because deleterious consequences and other sequelae, both systemic and local, can result from corticosteroid injections, especially from chronic use, large doses, and errant injection (e.g., into a tendon) [13].
Gene_expression (injections) of corticosteroid in tendon associated with corticosteroid
5) Confidence 0.13 Published 2007 Journal BMC Musculoskelet Disord Section Body Doc Link PMC1950874 Disease Relevance 0.09 Pain Relevance 0.46
For example, Hollander and co-workers have shown little evidence of morbidity of intra-articular corticosteroid injections that have been used for many years as a primary treatment modality for osteoarthritis of the knee [46,47].
Gene_expression (injections) of corticosteroid in knee associated with corticosteroid and osteoarthritis
6) Confidence 0.13 Published 2007 Journal BMC Musculoskelet Disord Section Body Doc Link PMC1950874 Disease Relevance 0.38 Pain Relevance 0.17
Our survey also queried physicians regarding whether or not they made adjustments in corticosteroid dosing based on patient age.
Gene_expression (dosing) of corticosteroid associated with corticosteroid
7) Confidence 0.13 Published 2007 Journal BMC Musculoskelet Disord Section Body Doc Link PMC1950874 Disease Relevance 0.84 Pain Relevance 0.50
This contradicts one facet of our first hypothesis predicting that significant differences would be found in corticosteroid doses between these groups.
Gene_expression (doses) of corticosteroid in facet associated with corticosteroid
8) Confidence 0.13 Published 2007 Journal BMC Musculoskelet Disord Section Body Doc Link PMC1950874 Disease Relevance 0.21 Pain Relevance 0.34
Using combined data from the three physician groups for each of the five injected locations, corticosteroid doses and local anesthetic volumes showed little or no correlation with years in practice (the absolute values of all ten r values are ?
Gene_expression (doses) of corticosteroid associated with corticosteroid and local anesthetic
9) Confidence 0.13 Published 2007 Journal BMC Musculoskelet Disord Section Body Doc Link PMC1950874 Disease Relevance 0 Pain Relevance 0.73
Subsequently, ACTH increases cortisol release from the adrenal glands, which then binds to a specific carrier – cortisol-binding globulin (CBG) – that is synthetized by the liver and to albumin in order to reach the target tissues.
Gene_expression (synthetized) of cortisol-binding globulin in liver
10) Confidence 0.12 Published 2004 Journal Crit Care Section Body Doc Link PMC522845 Disease Relevance 0.55 Pain Relevance 0.24
Studies comparing ABG and CBG, ABG and VBG samples in diabetic ketoacidosis, and ABG–CBG blood gases values in stable pediatric intensive care unit patients have shown good correlation among ABG, VBG, and CBG samples.[13] However, there have been no studies comparing simultaneously obtained ABG and earlobe samplings in stable adult ICU patients treated by mechanical ventilation.
Gene_expression (samples) of CBG in blood associated with ketoacidosis
11) Confidence 0.09 Published 2008 Journal Indian Journal of Critical Care Medicine : Peer-reviewed, Official Publication of Indian Society of Critical Care Medicine Section Body Doc Link PMC2738313 Disease Relevance 0.10 Pain Relevance 0
Complicating the concept of reward insensitivity among patients is that they and controls rated themselves similarly “happy” upon winning in the CBG (Fig. 2D).
Gene_expression (winning) of CBG
12) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2943904 Disease Relevance 0 Pain Relevance 0.13
The CBG presented 90 pairs of balloons, each pair including one DecBa (“You decide which button to press”) and one DirBa (“The computer will play the game.
Gene_expression (presented) of CBG
13) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2943904 Disease Relevance 0 Pain Relevance 0.05

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