INT179299

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Context Info
Confidence 0.24
First Reported 2004
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.02
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (TGM2) plasma membrane (TGM2) transferase activity, transferring acyl groups (TGM2)
cytoplasm (TGM2)
Anatomy Link Frequency
T-cell 2
TGM2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 39 5.00 Very Low Very Low Very Low
cytokine 10 5.00 Very Low Very Low Very Low
Inflammatory response 4 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
Bioavailability 2 5.00 Very Low Very Low Very Low
nud 2 5.00 Very Low Very Low Very Low
Infliximab 2 5.00 Very Low Very Low Very Low
withdrawal 2 5.00 Very Low Very Low Very Low
tolerance 2 5.00 Very Low Very Low Very Low
Migraine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 91 98.88 Very High Very High Very High
Malabsorption Syndromes 83 92.20 High High
Wound Healing 1 92.00 High High
Celiac Disease 105 80.16 Quite High
Targeted Disruption 4 71.40 Quite High
Acquired Immune Deficiency Syndrome Or Hiv Infection 4 46.20 Quite Low
Cancer 4 45.92 Quite Low
Gastrointestinal Neoplasms 1 42.12 Quite Low
Lymphatic System Cancer 6 40.96 Quite Low
Cervical Intraepithelial Neoplasia 1 40.80 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Following TG2-mediated deamidation at select Gln residues, these peptides bind with increased affinity to disease-associated HLA DQ2 molecules [134,135], and thereby possess increased stimulatory capacity toward DQ2-restricted gluten-reactive T cells [136,137].
TG2-mediated Binding (bind) of in T cells associated with disease
1) Confidence 0.24 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2323203 Disease Relevance 0.55 Pain Relevance 0
The shortest peptides tested were 12-mers; the T-cell line CD431.2 recognized peptide 1505 (YQPYPEQQEPFV) after TG2 treatment and the already deamidated peptide 1504 (YQPYPEQEEPFV) without TG2 treatment (Figure 3).
TG2 Binding (recognized) of in T-cell
2) Confidence 0.19 Published 2004 Journal PLoS Medicine Section Body Doc Link PMC523824 Disease Relevance 0.07 Pain Relevance 0
Tissue transglutaminase (tTG) was identified as the autoantigen, which is recognized by the endomysial antibodies [57,103] (see below).
Tissue transglutaminase Binding (recognized) of
3) Confidence 0.09 Published 2006 Journal Orphanet J Rare Dis Section Body Doc Link PMC1435993 Disease Relevance 0.40 Pain Relevance 0

General Comments

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