INT1793

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Context Info
Confidence 0.81
First Reported 1970
Last Reported 2010
Negated 4
Speculated 5
Reported most in Abstract
Documents 379
Total Number 385
Disease Relevance 67.38
Pain Relevance 114.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (CGA) small molecule metabolic process (CGA) extracellular region (CGA)
cellular nitrogen compound metabolic process (CGA) cell-cell signaling (CGA)
Anatomy Link Frequency
pituitary 34
follicle 13
gonadal 13
placenta 7
hypothalamus 6
CGA (Homo sapiens)
Pain Link Frequency Relevance Heat
narcan 660 99.92 Very High Very High Very High
Opioid 355 99.92 Very High Very High Very High
opiate 268 99.92 Very High Very High Very High
Morphine 121 99.92 Very High Very High Very High
Dynorphin 116 99.92 Very High Very High Very High
Endogenous opioid 121 99.88 Very High Very High Very High
Dopamine 113 99.88 Very High Very High Very High
tolerance 20 99.84 Very High Very High Very High
conotoxin 6 99.80 Very High Very High Very High
Serotonin 45 99.76 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cancer 155 100.00 Very High Very High Very High
Giant Cell Carcinoma 12 100.00 Very High Very High Very High
Reprotox - General 1 286 99.96 Very High Very High Very High
Renal Cell Carcinoma 15 99.96 Very High Very High Very High
Hot Flashes 24 99.90 Very High Very High Very High
Ectopic Pregnancy 434 99.80 Very High Very High Very High
Hypertrophy 4 99.80 Very High Very High Very High
Hydatidiform Mole 7 99.78 Very High Very High Very High
Hypoglycemia 2 99.78 Very High Very High Very High
Congenital Anomalies 62 99.62 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Patterns of secretion of human chorionic gonadotrophin by superfused placental explants and the embryo--placental relationship following maternal use of medications.
Localization (secretion) of chorionic gonadotrophin in embryo associated with codeine
1) Confidence 0.81 Published 1992 Journal Hum. Reprod. Section Title Doc Link 1587933 Disease Relevance 0.08 Pain Relevance 0.16
In the present study we have examined the consequences of maternal drug exposure in vivo upon placental secretion patterns of human chorionic gonadotrophin (HCG) and the relationship between the embryo and placenta in vitro.
Localization (secretion) of chorionic gonadotrophin in placenta
2) Confidence 0.81 Published 1992 Journal Hum. Reprod. Section Abstract Doc Link 1587933 Disease Relevance 0.09 Pain Relevance 0.03
The patterns of HCG secretion in superfused placental explants were different from those seen in control explants (without use of any medication).
Localization (secretion) of HCG
3) Confidence 0.81 Published 1992 Journal Hum. Reprod. Section Abstract Doc Link 1587933 Disease Relevance 0.10 Pain Relevance 0.07
In the present study we have examined the consequences of maternal drug exposure in vivo upon placental secretion patterns of human chorionic gonadotrophin (HCG) and the relationship between the embryo and placenta in vitro.
Localization (secretion) of HCG in placenta
4) Confidence 0.81 Published 1992 Journal Hum. Reprod. Section Abstract Doc Link 1587933 Disease Relevance 0.09 Pain Relevance 0.03
Maternal opiate use is known to be associated with problems of placental origin and it is possible that the secretion of alpha-feto protein (AFP), free-beta human chorionic gonadotrophin (HCG) and unconjugated oestriol (UE) differs from that of a normal population.
Localization (secretion) of HCG
5) Confidence 0.79 Published 2009 Journal Prenat. Diagn. Section Abstract Doc Link 19488976 Disease Relevance 0.17 Pain Relevance 0.26
In the present study the effect of physiological concentrations of beta-endorphin was examined upon human chorionic gonadotrophin (HCG) secretion by first trimester placental explants.
Spec (examined) Localization (secretion) of chorionic gonadotrophin
6) Confidence 0.79 Published 1991 Journal Hum. Reprod. Section Abstract Doc Link 1661290 Disease Relevance 0 Pain Relevance 0.34
In the present study the effect of physiological concentrations of beta-endorphin was examined upon human chorionic gonadotrophin (HCG) secretion by first trimester placental explants.
Spec (examined) Localization (secretion) of HCG
7) Confidence 0.79 Published 1991 Journal Hum. Reprod. Section Abstract Doc Link 1661290 Disease Relevance 0 Pain Relevance 0.34
Results show that at 7-9 weeks of gestation, beta-endorphin inhibited HCG secretion; a maximal suppression of 60% was noted at 5 x 10(-10) M concentrations, while fivefold lower or higher doses were less effective.
Localization (secretion) of HCG
8) Confidence 0.79 Published 1991 Journal Hum. Reprod. Section Abstract Doc Link 1661290 Disease Relevance 0 Pain Relevance 0.39
Effect of beta-endorphin on human chorionic gonadotrophin secretion by placental explants.
Localization (secretion) of chorionic gonadotrophin associated with narcan
9) Confidence 0.79 Published 1991 Journal Hum. Reprod. Section Title Doc Link 1661290 Disease Relevance 0 Pain Relevance 0.53
The opioid peptide specificity was demonstrated by the failure of N-acetyl-beta-endorphin, a non-opiate analogue used at the same concentration range, to affect HCG secretion.
Localization (secretion) of HCG associated with opiate and opioid
10) Confidence 0.79 Published 1991 Journal Hum. Reprod. Section Abstract Doc Link 1661290 Disease Relevance 0 Pain Relevance 0.59
The release of human chorionic gonadotrophin and placental lactogen by placental explants can be stimulated by Ca2+ entry through a Na(+)-Ca2+ exchange process.
Localization (release) of chorionic gonadotrophin
11) Confidence 0.78 Published 1994 Journal Placenta Section Title Doc Link 7997448 Disease Relevance 0 Pain Relevance 0.07
The effect of dynorphin on placental pulsatile human chorionic gonadotropin secretion in vitro.
Localization (secretion) of chorionic gonadotropin associated with dynorphin and narcan
12) Confidence 0.78 Published 1991 Journal J. Clin. Endocrinol. Metab. Section Title Doc Link 1682338 Disease Relevance 0 Pain Relevance 0.66
Clinical hyperthyroidism is found in approximately 5% of women with a hydatidiform mole, as human chorionic gonadotropin secreted by molar tissue is structurally similar to thyroid-stimulating hormone.
Localization (secreted) of chorionic gonadotropin in thyroid associated with hydatidiform mole and thyroid disease
13) Confidence 0.78 Published 2007 Journal Int J Obstet Anesth Section Abstract Doc Link 17459690 Disease Relevance 0.84 Pain Relevance 0.26
Isosmotical replacement of extracellular Na+ ([Na+]o) by K+, choline and to a lesser extent by saccharose stimulated the release of chorionic gonadotrophin and placental lactogen from human term placental explants.
Localization (release) of chorionic gonadotrophin
14) Confidence 0.78 Published 1994 Journal Placenta Section Abstract Doc Link 7997448 Disease Relevance 0 Pain Relevance 0.07
Endogenous catecholamines augment the inhibitory effect of opioids on luteinizing hormone secretion during the midluteal phase.
Localization (secretion) of luteinizing hormone associated with catecholamine, narcan and opioid
15) Confidence 0.74 Published 1993 Journal Am. J. Obstet. Gynecol. Section Title Doc Link 7903508 Disease Relevance 0 Pain Relevance 0.34
CONCLUSION: Endogenous catecholamines augment the inhibitory effect of opioids on luteinizing hormone secretion during the midluteal phase in normal cycling women.


Localization (secretion) of luteinizing hormone
16) Confidence 0.74 Published 1993 Journal Am. J. Obstet. Gynecol. Section Body Doc Link 7903508 Disease Relevance 0 Pain Relevance 0
Opioid control of gonadotrophin secretion in humans.
Localization (secretion) of gonadotrophin associated with opioid
17) Confidence 0.74 Published 1993 Journal Hum. Reprod. Section Title Doc Link 8276950 Disease Relevance 0.15 Pain Relevance 0.46
Recently, the involvement of endogenous opioid peptides (EOP) in the control of the neuroendocrine mechanism modulating gonadotrophin secretion has been supported by several authors.
Localization (secretion) of gonadotrophin associated with endogenous opioid
18) Confidence 0.74 Published 1993 Journal Hum. Reprod. Section Abstract Doc Link 8276950 Disease Relevance 0.15 Pain Relevance 0.44
A 60-year-man presented with painful gynaecomastia and polycythaemia due to a beta-human chorionic gonadotropin (HCG)-secreting clear cell renal cell carcinoma.
Localization (secreting) of HCG associated with pain, erythrocytosis and renal cell carcinoma
19) Confidence 0.71 Published 2008 Journal Scand. J. Urol. Nephrol. Section Abstract Doc Link 19031270 Disease Relevance 0.44 Pain Relevance 0.10
A 60-year-man presented with painful gynaecomastia and polycythaemia due to a beta-human chorionic gonadotropin (HCG)-secreting clear cell renal cell carcinoma.
Localization (secreting) of gonadotropin associated with pain, erythrocytosis and renal cell carcinoma
20) Confidence 0.70 Published 2008 Journal Scand. J. Urol. Nephrol. Section Abstract Doc Link 19031270 Disease Relevance 0.44 Pain Relevance 0.10

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