INT179307

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Context Info
Confidence 0.01
First Reported 2004
Last Reported 2011
Negated 1
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 1.93
Pain Relevance 0.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (GNAS) intracellular (GNAS) GTPase activity (GNAS)
transmembrane transport (GNAS) cytoplasm (GNAS) signal transducer activity (GNAS)
GNAS (Homo sapiens)
Pain Link Frequency Relevance Heat
Central nervous system 9 91.20 High High
Inflammation 14 5.00 Very Low Very Low Very Low
Crohn's disease 8 5.00 Very Low Very Low Very Low
cytokine 3 5.00 Very Low Very Low Very Low
cINOD 3 5.00 Very Low Very Low Very Low
Dismenorea 2 5.00 Very Low Very Low Very Low
abdominal pain 1 5.00 Very Low Very Low Very Low
Inflammatory stimuli 1 5.00 Very Low Very Low Very Low
potassium channel 1 5.00 Very Low Very Low Very Low
melanocortin 1 receptor 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Tauopathy 54 97.76 Very High Very High Very High
Supranuclear Palsy 45 90.80 High High
Repression 4 80.92 Quite High
Parkinson's Disease 9 76.24 Quite High
Frontotemporal Dementia 9 75.52 Quite High
Cancer 33 74.36 Quite High
Disease 77 72.80 Quite High
Basal Cell Carcinoma 28 62.64 Quite High
Hypersensitivity 2 60.76 Quite High
Hemolytic Uremic Syndrome 14 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, while there was no significant change in the mRNA levels of the 132 bp spliced exon in absolute terms between the three tissue sets, there was a significant increase (~1.7 fold) in the proportion of Maxi-K ?
Neg (no) Regulation (change) of exon
1) Confidence 0.01 Published 2004 Journal Reprod Biol Endocrinol Section Body Doc Link PMC524189 Disease Relevance 0 Pain Relevance 0
Therefore, modulation of exon 10 splicing in the tau gene could potentially be targeted to prevent tauopathies.
Regulation (modulation) of exon associated with tauopathy
2) Confidence 0.01 Published 2008 Journal BMC Neurosci Section Abstract Doc Link PMC2604894 Disease Relevance 0.80 Pain Relevance 0
In this review, we will discuss how realistic, specific biological molecules can be found to regulate exon 10 splicing in the tau gene for potential treatment of tauopathies.



Regulation (regulate) of exon associated with tauopathy
3) Confidence 0.01 Published 2008 Journal BMC Neurosci Section Abstract Doc Link PMC2604894 Disease Relevance 0.78 Pain Relevance 0
Alternative splicing of exon 10 is developmentally regulated.
Regulation (regulated) of exon
4) Confidence 0.01 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2604894 Disease Relevance 0 Pain Relevance 0.05
Expression of transcripts containing exon1a and 1b is driven by an alternative promoter located within a CpG island, whereas transcripts containing the canonical exon 1 are regulated by an NF-?
Regulation (regulated) of exon
5) Confidence 0.01 Published 2007 Journal BMC Genomics Section Body Doc Link PMC2228316 Disease Relevance 0.08 Pain Relevance 0
For sequencing (SeqLab; Göttingen, Germany), the p53 exons 5, 6, 7, and 8 were amplified with BioTherm Taq polymerase (GenCraft, Münster, Germany) by seminested PCR using the following primers which all target exon flanking intron sequences:


3.

Regulation (target) of exon
6) Confidence 0.00 Published 2011 Journal Journal of Skin Cancer Section Body Doc Link PMC2989759 Disease Relevance 0.21 Pain Relevance 0
In addition, there was a heterozygous synonymous change in exon 22.
Regulation (change) of exon
7) Confidence 0.00 Published 2006 Journal PLoS Medicine Section Body Doc Link PMC1626556 Disease Relevance 0.06 Pain Relevance 0

General Comments

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