INT179309

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Context Info
Confidence 0.39
First Reported 2004
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 8
Total Number 9
Disease Relevance 2.36
Pain Relevance 1.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (KCNMA1) transmembrane transport (KCNMA1)
Anatomy Link Frequency
neuronal 2
brain 2
KCNMA1 (Homo sapiens)
Pain Link Frequency Relevance Heat
sodium channel 10 100.00 Very High Very High Very High
Pain 142 98.72 Very High Very High Very High
Inflammatory mediators 2 97.28 Very High Very High Very High
Neuronal excitability 1 95.72 Very High Very High Very High
potassium channel 147 90.96 High High
Dismenorea 9 90.24 High High
Paroxysmal pain 1 87.28 High High
Inflammation 4 82.36 Quite High
Analgesic 9 72.52 Quite High
IPN 2 58.20 Quite High
Disease Link Frequency Relevance Heat
Pain 148 98.72 Very High Very High Very High
Coronary Heart Disease 1 97.40 Very High Very High Very High
INFLAMMATION 6 96.88 Very High Very High Very High
Frailty 1 96.64 Very High Very High Very High
Targeted Disruption 10 94.00 High High
Nociception 11 90.80 High High
Dysmenorrhea 9 90.24 High High
Cancer 14 89.76 High High
Uterine Fibroids 1 85.68 High High
Hepatocellular Cancer 1 84.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The 3' conserved region of the Maxi-K ?
Regulation (conserved) of Gene_expression (region) of Maxi-K
1) Confidence 0.39 Published 2004 Journal Reprod Biol Endocrinol Section Body Doc Link PMC524189 Disease Relevance 0 Pain Relevance 0
The results of expression analyses for the 87 bp and 132 bp spliced exons as a proportion of the total Maxi-K ?
Spec (analyses) Regulation (results) of Gene_expression (proportion) of Maxi-K
2) Confidence 0.34 Published 2004 Journal Reprod Biol Endocrinol Section Body Doc Link PMC524189 Disease Relevance 0 Pain Relevance 0
Using the RNAi technology, we have investigated the response of PC3 and LNCaP cell lines to selenium treatment in the presence of low expression levels of KCNMA1, the most significant candidate gene discovered in the present study.
Spec (investigated) Regulation (response) of Gene_expression (expression) of KCNMA1
3) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935366 Disease Relevance 1.21 Pain Relevance 0
This dysregulation may be the result of changes in channel expression levels, post-translational modulation and/or variant channel expression and dysfunctional channel assembly.
Regulation (changes) of Gene_expression (expression) of channel
4) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2928262 Disease Relevance 0.09 Pain Relevance 0.13
This dysregulation may be the result of changes in channel expression levels, post-translational modulation and/or variant channel expression and dysfunctional channel assembly.
Regulation (changes) of Gene_expression (expression) of channel
5) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2928262 Disease Relevance 0.09 Pain Relevance 0.13
This dysregulation may be the result of changes in channel expression levels, post-translational modulation and/or variant channel expression and dysfunctional channel assembly.
Regulation (changes) of Gene_expression (expression) of channel
6) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2928262 Disease Relevance 0.08 Pain Relevance 0.13
This dysregulation may be the result of changes in channel expression levels, post-translational modulation and/or variant channel expression and dysfunctional channel assembly.
Regulation (changes) of Gene_expression (expression) of channel
7) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2928262 Disease Relevance 0.09 Pain Relevance 0.13
Human brain served as a positive control for channel expression.
Regulation (control) of Gene_expression (expression) of channel in brain
8) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2928262 Disease Relevance 0 Pain Relevance 0.05
Regulation of sodium channel expression, both transcriptionally and
               posttranscriptionally, is an important element in determining neuronal excitability.
               
Regulation (Regulation) of Gene_expression (expression) of channel in neuronal associated with neuronal excitability and sodium channel
9) Confidence 0.00 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2432024 Disease Relevance 0.80 Pain Relevance 0.80

General Comments

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