INT179311

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Context Info
Confidence 0.10
First Reported 2004
Last Reported 2007
Negated 4
Speculated 0
Reported most in Body
Documents 2
Total Number 14
Disease Relevance 0.67
Pain Relevance 2.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (GNAS) intracellular (GNAS) GTPase activity (GNAS)
transmembrane transport (GNAS) cytoplasm (GNAS) signal transducer activity (GNAS)
Anatomy Link Frequency
colon 2
muscle 2
caudate nucleus 1
medulla 1
brain 1
GNAS (Homo sapiens)
Pain Link Frequency Relevance Heat
Thalamus 13 99.78 Very High Very High Very High
medulla 26 99.14 Very High Very High Very High
amygdala 39 95.84 Very High Very High Very High
Substantia nigra 13 92.80 High High
Hippocampus 91 91.36 High High
Spinal cord 39 86.08 High High
Central nervous system 13 74.32 Quite High
cerebral cortex 39 64.52 Quite High
Pain 13 11.36 Low Low
Nerve growth factor 26 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 13 92.00 High High
Huntington's Chorea 13 44.80 Quite Low
Neurodegenerative Disease 13 43.32 Quite Low
Cognitive Disorder 13 38.96 Quite Low
Pain 13 11.36 Low Low
Neuroblastoma 13 7.28 Low Low
Nervous System Malformation 13 7.04 Low Low
Dysmenorrhea 2 5.00 Very Low Very Low Very Low
Emergencies 2 5.00 Very Low Very Low Very Low
Breech Presentation 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interestingly, in the brain structures that contain only glial cells and axons and do not contain neuronal cell bodies, such as corpus callosum and optic nerve, exon IXabcd transcripts were predominantly detected.
Transcription (detected) of exon in neuronal
1) Confidence 0.10 Published 2007 Journal Genomics Section Body Doc Link PMC2568880 Disease Relevance 0 Pain Relevance 0.13
BDNF expression was also very low in the globus pallidus, striatum (caudate nucleus and putamen), and thalamus, with the exception of exon IXabcd transcripts, which were expressed at relatively high levels in these regions.
Transcription (expressed) of exon in striatum associated with thalamus
2) Confidence 0.10 Published 2007 Journal Genomics Section Body Doc Link PMC2568880 Disease Relevance 0.08 Pain Relevance 0.22
According to the most recent description of the organization of the human BDNF gene locus and alternatively spliced transcripts the human BDNF has seven noncoding and one coding exon [19].
Transcription (description) of exon
3) Confidence 0.10 Published 2007 Journal Genomics Section Body Doc Link PMC2568880 Disease Relevance 0 Pain Relevance 0.17
BDNF expression was also very low in the globus pallidus, striatum (caudate nucleus and putamen), and thalamus, with the exception of exon IXabcd transcripts, which were expressed at relatively high levels in these regions.
Neg (exception) Transcription (exception) of exon in putamen associated with thalamus
4) Confidence 0.10 Published 2007 Journal Genomics Section Body Doc Link PMC2568880 Disease Relevance 0.08 Pain Relevance 0.22
For example, antiBDNF transcripts with exon 10 were present in the colon and muscle, whereas transcripts with exon 9 were not expressed in these tissues.
Transcription (transcripts) of exon in colon
5) Confidence 0.10 Published 2007 Journal Genomics Section Body Doc Link PMC2568880 Disease Relevance 0 Pain Relevance 0.07
All BDNF transcripts except the ones containing exons V and VII were expressed at high levels in the cerebellum and medulla, and all transcripts but those containing exon IXabcd were expressed at high levels in the infundibulum.
Transcription (expressed) of exon in medulla associated with medulla
6) Confidence 0.10 Published 2007 Journal Genomics Section Body Doc Link PMC2568880 Disease Relevance 0.09 Pain Relevance 0.21
Exon IXabcd mRNAs were expressed at relatively similar levels in all brain regions, with only infundibulum having very low expression levels.
Transcription (expressed) of Exon in brain
7) Confidence 0.08 Published 2007 Journal Genomics Section Body Doc Link PMC2568880 Disease Relevance 0.06 Pain Relevance 0.18
For example, antiBDNF transcripts with exon 10 were present in the colon and muscle, whereas transcripts with exon 9 were not expressed in these tissues.
Neg (not) Transcription (expressed) of exon in colon
8) Confidence 0.08 Published 2007 Journal Genomics Section Body Doc Link PMC2568880 Disease Relevance 0.05 Pain Relevance 0.07
All BDNF transcripts except the ones containing exons V and VII were expressed at high levels in the cerebellum and medulla, and all transcripts but those containing exon IXabcd were expressed at high levels in the infundibulum.
Transcription (expressed) of exon in cerebellum associated with medulla
9) Confidence 0.03 Published 2007 Journal Genomics Section Body Doc Link PMC2568880 Disease Relevance 0.09 Pain Relevance 0.21
For example, antiBDNF transcripts with exon 10 were present in the colon and muscle, whereas transcripts with exon 9 were not expressed in these tissues.
Transcription (transcripts) of exon in muscle
10) Confidence 0.03 Published 2007 Journal Genomics Section Body Doc Link PMC2568880 Disease Relevance 0 Pain Relevance 0.07
BDNF expression was also very low in the globus pallidus, striatum (caudate nucleus and putamen), and thalamus, with the exception of exon IXabcd transcripts, which were expressed at relatively high levels in these regions.
Transcription (expressed) of exon in globus pallidus associated with thalamus
11) Confidence 0.03 Published 2007 Journal Genomics Section Body Doc Link PMC2568880 Disease Relevance 0.08 Pain Relevance 0.22
BDNF expression was also very low in the globus pallidus, striatum (caudate nucleus and putamen), and thalamus, with the exception of exon IXabcd transcripts, which were expressed at relatively high levels in these regions.
Neg (exception) Transcription (exception) of exon in caudate nucleus associated with thalamus
12) Confidence 0.03 Published 2007 Journal Genomics Section Body Doc Link PMC2568880 Disease Relevance 0.08 Pain Relevance 0.22
For example, antiBDNF transcripts with exon 10 were present in the colon and muscle, whereas transcripts with exon 9 were not expressed in these tissues.
Neg (not) Transcription (expressed) of exon in muscle
13) Confidence 0.03 Published 2007 Journal Genomics Section Body Doc Link PMC2568880 Disease Relevance 0.05 Pain Relevance 0.07
In contrast, while there was no significant change in the mRNA levels of the 132 bp spliced exon in absolute terms between the three tissue sets, there was a significant increase (~1.7 fold) in the proportion of Maxi-K ?
Transcription (levels) of exon
14) Confidence 0.01 Published 2004 Journal Reprod Biol Endocrinol Section Body Doc Link PMC524189 Disease Relevance 0 Pain Relevance 0

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