INT179319

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Context Info
Confidence 0.70
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 5
Disease Relevance 2.02
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (KCNMA1) transmembrane transport (KCNMA1)
Anatomy Link Frequency
uterine 1
KCNMA1 (Homo sapiens)
Pain Link Frequency Relevance Heat
potassium channel 2 49.84 Quite Low
Dismenorea 4 29.00 Quite Low
member 8 3 5.00 Very Low Very Low Very Low
chemokine 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 9 86.48 High High
Prostate Cancer 33 86.40 High High
Cancer 39 85.12 High High
Coronary Heart Disease 3 76.32 Quite High
Frailty 3 75.56 Quite High
Uterine Fibroids 3 64.60 Quite High
Hepatocellular Cancer 3 63.48 Quite High
Breast Cancer 6 62.20 Quite High
Metastasis 3 54.44 Quite High
Pre-term Labor 2 51.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Evaluation of the mRNA expression of KCNMA1 by qRT-PCR in the significant probe sets (K6 and K7) showed 2-fold decrease in gene expression in the selenium-treated cells.
Transcription (expression) of KCNMA1
1) Confidence 0.70 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935366 Disease Relevance 0.90 Pain Relevance 0
The knockdown ratio of KCNMA1 mRNA expression has validated the reduced expression in cells treated and untreated with selenium.
Transcription (expression) of KCNMA1
2) Confidence 0.70 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935366 Disease Relevance 1.07 Pain Relevance 0
All further PCR for KCNMA1 mRNA quantification were performed using standard RNA dilution curves.
Transcription (quantification) of KCNMA1
3) Confidence 0.68 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935366 Disease Relevance 0 Pain Relevance 0
subunit of the slo gene family, and a regulatory ?
Transcription (subunit) of slo
4) Confidence 0.60 Published 2004 Journal Reprod Biol Endocrinol Section Body Doc Link PMC524189 Disease Relevance 0.05 Pain Relevance 0
Our findings suggest that decreased Maxi-K alpha subunit mRNA expression in human myometrium at labour onset, coupled to an increased proportion of Maxi-K channels expressing the 132 bp spliced exon, may be linked to decreased Maxi-K channel calcium and voltage sensitivity, thereby promoting enhanced uterine activity at the time of labour.



Transcription (expression) of Maxi-K in uterine
5) Confidence 0.47 Published 2004 Journal Reprod Biol Endocrinol Section Abstract Doc Link PMC524189 Disease Relevance 0 Pain Relevance 0

General Comments

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