INT179325

Context Info Confidence 0.43 First Reported 2004 Last Reported 2004 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.82 Pain Relevance 0.04

signal transduction (KIT) extracellular space (KIT) plasma membrane (KIT) nucleus (KIT) cytoplasm (KIT)

KIT (Homo sapiens)

Pain Link Frequency Relevance Heat Central nervous system 7 77.92 headache 1 5.00 imagery 1 5.00 abdominal pain 1 5.00

Disease Link Frequency Relevance Heat Leukemia 1 88.88 Cancer 8 88.32 Myeloid Leukemia 3 86.80 Gastrointestinal Stromal Tumor 18 83.64 Disease Progression 6 79.00 Recurrence 11 64.72 Disease 10 63.76 Melena 1 52.00 Metastasis 16 9.36 Diplopia 7 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

It specifically targets the c-kit (CD117) proto-oncogene gain of function mutation characterising GISTs, blocking the c-kit kinase, leading to growth cessation and significant durable clinical remissions.

Negative_regulation (blocking) of Regulation (targets) of kit

1) Confidence 0.43 Published 2004 Journal BMC Cancer Section Body Doc Link PMC524360 Disease Relevance 0.82 Pain Relevance 0.04

General Comments

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