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Context Info
Confidence 0.43
First Reported 2004
Last Reported 2004
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.82
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (KIT) extracellular space (KIT) plasma membrane (KIT)
nucleus (KIT) cytoplasm (KIT)
KIT (Homo sapiens)
Pain Link Frequency Relevance Heat
Central nervous system 7 77.92 Quite High
headache 1 5.00 Very Low Very Low Very Low
imagery 1 5.00 Very Low Very Low Very Low
abdominal pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Leukemia 1 88.88 High High
Cancer 8 88.32 High High
Myeloid Leukemia 3 86.80 High High
Gastrointestinal Stromal Tumor 18 83.64 Quite High
Disease Progression 6 79.00 Quite High
Recurrence 11 64.72 Quite High
Disease 10 63.76 Quite High
Melena 1 52.00 Quite High
Metastasis 16 9.36 Low Low
Diplopia 7 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It specifically targets the c-kit (CD117) proto-oncogene gain of function mutation characterising GISTs, blocking the c-kit kinase, leading to growth cessation and significant durable clinical remissions.
Negative_regulation (blocking) of Regulation (targets) of kit
1) Confidence 0.43 Published 2004 Journal BMC Cancer Section Body Doc Link PMC524360 Disease Relevance 0.82 Pain Relevance 0.04

General Comments

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