INT179337

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Context Info
Confidence 0.05
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 14
Total Number 14
Disease Relevance 3.73
Pain Relevance 0.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Ecm1) extracellular space (Ecm1) extracellular region (Ecm1)
proteinaceous extracellular matrix (Ecm1) enzyme binding (Ecm1) signal transducer activity (Ecm1)
Anatomy Link Frequency
skin 6
stroma 4
ECM 2
lung 2
cornea 2
Ecm1 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 48 97.76 Very High Very High Very High
ischemia 2 96.64 Very High Very High Very High
antagonist 9 94.24 High High
Inflammation 140 88.00 High High
Chronic pancreatitis 8 73.56 Quite High
Neuropeptide 2 72.88 Quite High
fibrosis 171 71.28 Quite High
cva 5 62.48 Quite High
rheumatoid arthritis 45 58.80 Quite High
Osteoarthritis 20 58.52 Quite High
Disease Link Frequency Relevance Heat
Fibrosis 262 100.00 Very High Very High Very High
Apoptosis 110 100.00 Very High Very High Very High
Hepatotoxicity 2 98.40 Very High Very High Very High
Reperfusion Injury 2 97.40 Very High Very High Very High
Cv Unclassified Under Development 1 96.64 Very High Very High Very High
Disease 88 94.92 High High
Atherosclerosis 77 93.16 High High
Cirrhosis 11 91.84 High High
INFLAMMATION 152 88.00 High High
Sepsis 10 86.44 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To produce ECM with suppressed FBLN-1C expression, ASM cells were seeded in 75 cm2 flasks and transfected as described above.
Positive_regulation (transfected) of Gene_expression (produce) of ECM
1) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2954173 Disease Relevance 0 Pain Relevance 0
-mediated ECM production.
Positive_regulation (mediated) of Gene_expression (production) of ECM
2) Confidence 0.05 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2597201 Disease Relevance 0.71 Pain Relevance 0.04
induced apoptosis and ECM production, both process mediated by Smad activation.
Positive_regulation (induced) of Gene_expression (production) of ECM associated with apoptosis
3) Confidence 0.05 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2597201 Disease Relevance 0.55 Pain Relevance 0.04
HS fragments are also generated upon ECM oxidation by reactive oxygen species (ROS).
Positive_regulation (upon) of Gene_expression (oxidation) of ECM
4) Confidence 0.04 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2913853 Disease Relevance 0.65 Pain Relevance 0.09
siRNAs of SPARC and Ctgf attenuated over-expression of collagen and other fibrotic ECM genes induced by bleomycin in skin and lung tissues
Positive_regulation (over) of Gene_expression (expression) of ECM in skin associated with fibrosis
5) Confidence 0.04 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888211 Disease Relevance 0.10 Pain Relevance 0
siRNAs of SPARC and Ctgf attenuated over-expression of collagen and other fibrotic ECM genes induced by bleomycin in skin and lung tissues
Positive_regulation (expression) of Gene_expression (expression) of ECM in skin associated with fibrosis
6) Confidence 0.04 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888211 Disease Relevance 0.10 Pain Relevance 0
Gelatin hydrogels alone function to induce ECM production to some extent in vivo, but the efficacy is not as high as that of the gelatin hydrogels with precursors.
Positive_regulation (induce) of Gene_expression (production) of ECM
7) Confidence 0.02 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2566587 Disease Relevance 0 Pain Relevance 0
This study demonstrated that the required number of spheres per cornea was 10 spheres to promote the expression of ECM.
Positive_regulation (promote) of Gene_expression (expression) of ECM in cornea
8) Confidence 0.02 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2566587 Disease Relevance 0.60 Pain Relevance 0.07
Both precursors and gelatin may promote the production of ECM derived from the host stroma and not the transplanted cells.
Positive_regulation (derived) of Gene_expression (production) of ECM in stroma
9) Confidence 0.02 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2566587 Disease Relevance 0 Pain Relevance 0
The transplanted gelatin hydrogels with fibroblast precursors induced the production of ECM by the host stroma.
Positive_regulation (induced) of Gene_expression (production) of ECM in stroma
10) Confidence 0.02 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2566587 Disease Relevance 0 Pain Relevance 0
In response to profibrogenic mediators such as various cytokines, PSCs undergo an activation process that involves proliferation, exhibition of a myofibroblastic phenotype and enhanced production of ECM proteins.
Positive_regulation (enhanced) of Gene_expression (production) of ECM in ECM associated with cytokine
11) Confidence 0.01 Published 2004 Journal Mol Cancer Section Abstract Doc Link PMC524499 Disease Relevance 0.61 Pain Relevance 0.21
siRNAs of SPARC and Ctgf attenuated over-expression of collagen and other fibrotic ECM genes induced by bleomycin in skin and lung tissues
Positive_regulation (over) of in lung Gene_expression (expression) of ECM in skin associated with fibrosis
12) Confidence 0.01 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888211 Disease Relevance 0.10 Pain Relevance 0
siRNAs of SPARC and Ctgf attenuated over-expression of collagen and other fibrotic ECM genes induced by bleomycin in skin and lung tissues
Positive_regulation (expression) of in lung Gene_expression (expression) of ECM in skin associated with fibrosis
13) Confidence 0.01 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888211 Disease Relevance 0.10 Pain Relevance 0
This cell is not only responsible for the synthesis of the complex ECM of the articular cartilage, but it is also the source of proteinases and other mediators that degrade the damaged matrix to permit repair [33].
Positive_regulation (responsible) of Gene_expression (synthesis) of ECM in articular cartilage
14) Confidence 0.01 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2212555 Disease Relevance 0.21 Pain Relevance 0.14

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