INT179338

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Context Info
Confidence 0.55
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 8
Disease Relevance 5.75
Pain Relevance 3.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Timp2) nucleus (Timp2)
Anatomy Link Frequency
astrocytes 1
fibroblasts 1
Lung 1
Timp2 (Mus musculus)
Pain Link Frequency Relevance Heat
metalloproteinase 261 100.00 Very High Very High Very High
antagonist 15 96.84 Very High Very High Very High
Kinase C 1 93.68 High High
Inflammation 51 87.16 High High
fibrosis 72 84.68 Quite High
Bioavailability 1 74.96 Quite High
palliative 86 58.08 Quite High
ischemia 2 26.80 Quite Low
cytokine 29 13.52 Low Low
Inflammatory response 8 6.60 Low Low
Disease Link Frequency Relevance Heat
Metastasis 69 99.50 Very High Very High Very High
Cancer 312 98.96 Very High Very High Very High
Lung Cancer 272 98.48 Very High Very High Very High
Lifespan 16 98.32 Very High Very High Very High
Fibrosis 96 97.48 Very High Very High Very High
Death 5 97.20 Very High Very High Very High
Malignant Neoplastic Disease 24 95.44 Very High Very High Very High
Osteogenic Sarcomas 1 92.08 High High
Skin Cancer 6 89.04 High High
Diabetes Mellitus 1 88.32 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Protein levels of MMP2, TIMP2, VEGF, and endostatin in tumor extracts were measured via commercial available MMP2 (R&D Systems, Minneapolis, MN), TIMP2 (Amersham Biosciences, Buckinghamshire, UK), VEGF enzyme-linked immunosorbent assay (ELISA; R&D Systems, Minneapolis, MN), and endostatin (Chemicon International, Temecula, CA) kits.
Gene_expression (levels) of TIMP2 associated with cancer
1) Confidence 0.55 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2976755 Disease Relevance 0.17 Pain Relevance 0
Lung metastases, MMP2 activity, protein levels of MMP2, TIMP2, and VEGF, and microvessel density (MVD) were determined.


Gene_expression (levels) of TIMP2 in Lung associated with metastasis
2) Confidence 0.55 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2976755 Disease Relevance 0.91 Pain Relevance 0.17
Indeed, fibroblasts promote growth in MCF7 cells in vivo that can be inhibited with TIMP-2 or synthetic MMP inhibitor [24].
Gene_expression (synthetic) of TIMP-2 in fibroblasts associated with metalloproteinase
3) Confidence 0.43 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1450297 Disease Relevance 1.14 Pain Relevance 0.43
In rodents, MMP-2, MMP-3, MMP-9, MMP-13, MMP-14, as well as TIMP-1 and TIMP-2 are expressed in early stages of HSC activation and have been implicated in fibrogenesis as well as fibrolysis (reviewed in [20]).
Gene_expression (expressed) of TIMP-2 associated with fibrosis
4) Confidence 0.39 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2892485 Disease Relevance 0.87 Pain Relevance 0.30
In ET-1-activated human optic nerve head astrocytes, levels of MMP-1, TIMP-1, and TIMP-2 are all increased.
Gene_expression (levels) of TIMP-2 in astrocytes
5) Confidence 0.22 Published 2010 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2913859 Disease Relevance 0.55 Pain Relevance 0.20
Thus, PSCs have been shown to secrete MMP-2, MMP-9 and MMP-13 and to express TIMP-1 and TIMP-2 [73].
Gene_expression (express) of TIMP-2
6) Confidence 0.14 Published 2004 Journal Mol Cancer Section Body Doc Link PMC524499 Disease Relevance 0.52 Pain Relevance 0.24
MMP-2 and TIMP-2 mRNA expression was significantly higher in peritoneal compared to pleural MM effusions (Sivertsen, 2006).
Gene_expression (expression) of TIMP-2 mRNA associated with lung cancer and metalloproteinase
7) Confidence 0.04 Published 2007 Journal Biomarker Insights Section Body Doc Link PMC2717840 Disease Relevance 0.78 Pain Relevance 0.87
Our group recently found expression of MMP-2, MMP-9, MMP-14 (MT1-MMP) and TIMP-2 and activation of MMP-2 and MMP-9 in MM effusions (Sivertsen, 2006).
Gene_expression (expression) of TIMP-2 associated with lung cancer and metalloproteinase
8) Confidence 0.04 Published 2007 Journal Biomarker Insights Section Body Doc Link PMC2717840 Disease Relevance 0.82 Pain Relevance 0.91

General Comments

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