INT17934

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Context Info
Confidence 0.80
First Reported 1984
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 16
Total Number 17
Disease Relevance 2.83
Pain Relevance 2.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (MLN) cell-cell signaling (MLN)
Anatomy Link Frequency
duodenum 2
plasma 1
muscle 1
gum 1
endocrine cells 1
MLN (Homo sapiens)
Pain Link Frequency Relevance Heat
Serotonin 9 100.00 Very High Very High Very High
Neurotransmitter 5 99.96 Very High Very High Very High
substance P 1 99.32 Very High Very High Very High
Potency 1 96.28 Very High Very High Very High
Somatostatin 25 95.78 Very High Very High Very High
nud 6 93.24 High High
abdominal pain 5 92.72 High High
Neuropeptide 29 87.24 High High
tetrodotoxin 7 87.08 High High
behavioral therapy 1 86.16 High High
Disease Link Frequency Relevance Heat
Hepatic Porphyrias 1 97.68 Very High Very High Very High
Constipation 13 94.32 High High
Dyspepsia 6 93.24 High High
Abdominal Pain 5 92.72 High High
Paratuberculosis 20 92.24 High High
Recurrence 7 90.92 High High
INFLAMMATION 18 85.60 High High
Pain 7 83.80 Quite High
Functional Bowel Disorder 2 83.80 Quite High
Vomiting 8 80.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In man, there appears to be a close association of motilin secretion with biliary and pancreatic secretions being emptied into the duodenum and less evidence for motor activity releasing motilin.
Localization (secretion) of motilin in duodenum
1) Confidence 0.80 Published 1984 Journal Life Sci. Section Abstract Doc Link 6381948 Disease Relevance 0.05 Pain Relevance 0.12
Motilin is a 22-amino acid peptide hormone secreted by the enterochromaffin cells of the small intestine [4,5].
Localization (secreted) of Motilin in enterochromaffin cells
2) Confidence 0.77 Published 2008 Journal BMC Gastroenterol Section Body Doc Link PMC2529327 Disease Relevance 0.60 Pain Relevance 0.04
The strong antral contractions induced by erythromycin are not mediated by the release of motilin.
Localization (release) of motilin
3) Confidence 0.70 Published 1991 Journal Gastroenterology Section Abstract Doc Link 1955115 Disease Relevance 0.64 Pain Relevance 0.37
In most species motilin releases neurotransmitters in the CNS to both increase and decrease neural transmission and in the gastrointestinal tract to increase motor activity.
Localization (releases) of motilin in neural associated with neurotransmitter
4) Confidence 0.70 Published 1984 Journal Life Sci. Section Abstract Doc Link 6381948 Disease Relevance 0 Pain Relevance 0.13
In man, there appears to be a close association of motilin secretion with biliary and pancreatic secretions being emptied into the duodenum and less evidence for motor activity releasing motilin.
Localization (releasing) of motilin in duodenum
5) Confidence 0.69 Published 1984 Journal Life Sci. Section Abstract Doc Link 6381948 Disease Relevance 0.06 Pain Relevance 0.11
During acute attacks of hepatic porphyria, levels of polypeptides, vasoactive intestinal peptides, neurotensin, substance P, pancreatic polypeptide, gastrin releasing polypeptide, gastrin, and motilin increased in the circulation while the clinical symptoms were evident.
Localization (releasing) of motilin associated with hepatic porphyrias and substance p
6) Confidence 0.68 Published 1997 Journal Ther Apher Section Abstract Doc Link 10225763 Disease Relevance 0.17 Pain Relevance 0.24
Film autoradiograms showed that 125I-motilin-binding sites were localized in the muscle layers, and that the labeling disappeared in the presence of a 1000 times molar concentration of EM574.
Localization (localized) of 125I-motilin in muscle
7) Confidence 0.65 Published 1994 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7965757 Disease Relevance 0 Pain Relevance 0.16
Motilin isolated in 1971 from the porcine gastrointestinal tract and localized there to endocrine cells, now appears to have a CNS neural origin by RIA and immunohistochemistry.
Localization (localized) of Motilin in endocrine cells
8) Confidence 0.61 Published 1984 Journal Life Sci. Section Abstract Doc Link 6381948 Disease Relevance 0 Pain Relevance 0.11
In both settings, PP levels were significantly increased after bethanechol, while release of neurotensin, motilin, gastrin and cholylglycine was unaffected.
Localization (release) of motilin
9) Confidence 0.46 Published 2005 Journal Neurogastroenterol. Motil. Section Body Doc Link 16185316 Disease Relevance 0 Pain Relevance 0
Motilin plasma levels increase cyclically every 90–120 minutes during the interdigestive fasting period, and this cyclical release of motilin disappears after ingestion of a meal.
Localization (release) of motilin in plasma
10) Confidence 0.46 Published 2010 Journal International Journal of Peptides Section Body Doc Link PMC2925306 Disease Relevance 0 Pain Relevance 0
As for the case of motilin, Tack et al. [21] demonstrated that, in humans, the administration of ghrelin induces a premature gastric phase III, which is not mediated through the release of motilin.
Localization (release) of motilin
11) Confidence 0.40 Published 2010 Journal International Journal of Peptides Section Body Doc Link PMC2925306 Disease Relevance 0 Pain Relevance 0.11
Group A7 is also composed of receptors for peptide ligands: neuromedin, neurotensin, motilin, endothelin, bombesin and the releasing hormones for growth hormone and thyrotropin.
Localization (releasing) of motilin
12) Confidence 0.28 Published 2002 Journal Genome Biol Section Body Doc Link PMC133447 Disease Relevance 0 Pain Relevance 0.27
Octreotide has effects similar to those of somatostatin but with greater potency and longer duration of action; these effects include inhibition of pituitary release of growth hormone and thyrotropin, inhibition of glucagon or insulin release, and inhibition of the secretion of various gastrointestinal tract hormones (e.g. serotonin, pepsin, gastrin, secretin, motilin, vasoactive intestinal peptide and pancreatic peptides) [9,10].
Localization (secretion) of motilin in pituitary associated with somatostatin, serotonin and potency
13) Confidence 0.21 Published 2005 Journal Crit Care Section Body Doc Link PMC1414034 Disease Relevance 0.73 Pain Relevance 0.26
HAART did not prevent the decrease in GC size in MLN, observed at D14p.i., but cured the increase in GC and other changes observed at D28p.i..
Localization (decrease) of MLN
14) Confidence 0.15 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2695011 Disease Relevance 0.33 Pain Relevance 0.10
The effect of incorporating guar gum into predominantly single-component meals of carbohydrate, fat or protein on liquid gastric emptying and on the secretion of gastric inhibitory polypeptide (GIP), gastrin and motilin, was studied in healthy human volunteers.
Localization (secretion) of motilin in gum
15) Confidence 0.13 Published 1985 Journal Br. J. Nutr. Section Abstract Doc Link 4063284 Disease Relevance 0 Pain Relevance 0.08
Cluster 5 is composed of receptors for neurotensin (NT), neuromedin U (NMU), motilin, growth hormone secretagogue, thyrotropin-releasing hormone and some of PRX-amide peptides.
Localization (secretagogue) of motilin in NMU
16) Confidence 0.06 Published 2005 Journal BMC Genomics Section Body Doc Link PMC1192796 Disease Relevance 0 Pain Relevance 0.07
Spleens and MLN from individual mice were mechanically dissociated, and red blood cells were lysed with ACK lysis buffer (Sigma), 14 weeks after challenge.
Localization (Spleens) of MLN in red blood cells
17) Confidence 0.06 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2443107 Disease Relevance 0.24 Pain Relevance 0.08

General Comments

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