INT179360

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Context Info
Confidence 0.11
First Reported 2004
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 6
Disease Relevance 5.09
Pain Relevance 0.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (HDLBP) transport (HDLBP) RNA binding (HDLBP)
plasma membrane (HDLBP) nucleus (HDLBP) cytoplasm (HDLBP)
Anatomy Link Frequency
blood 1
HDLBP (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 112 95.68 Very High Very High Very High
Inflammation 24 60.96 Quite High
methotrexate 6 57.28 Quite High
Bile 41 33.44 Quite Low
backache 1 29.68 Quite Low
abdominal pain 1 29.12 Quite Low
Bioavailability 1 20.04 Low Low
agonist 9 5.00 Very Low Very Low Very Low
beta blocker 6 5.00 Very Low Very Low Very Low
aspirin 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 208 99.96 Very High Very High Very High
Hyperlipidemia 29 99.88 Very High Very High Very High
Dyslipidemia /

Combined Dyslipidemia

53 99.02 Very High Very High Very High
Metabolic Syndrome 76 97.04 Very High Very High Very High
Diabetes Mellitus 82 96.12 Very High Very High Very High
Rheumatoid Arthritis 112 95.68 Very High Very High Very High
Insulin Resistance 15 94.24 High High
Cardiovascular Disease 34 93.40 High High
Coronary Artery Disease 68 82.64 Quite High
Infarction 6 78.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Ezetimibe significantly lowered total-Cholesterol (TC) (12 %), LDL-C (18 %), apolipoprotein B (Apo B) (15 %), and triglycerides (TG) (7%) and increased high density lipoprotein (HDL-C) (3.5%) [22-24].
Positive_regulation (increased) of high density lipoprotein associated with disorder of lipid metabolism
1) Confidence 0.11 Published 2004 Journal Lipids Health Dis Section Body Doc Link PMC524501 Disease Relevance 0.53 Pain Relevance 0
After immunointervention autoantibody titers against all types of oxLDL were decreased in parallel to the increase in high-density lipoprotein-cholesterol and high-density lipoprotein-Lp-PLA2 activity.
Positive_regulation (increase) of high-density lipoprotein
2) Confidence 0.07 Published 2007 Journal Arthritis Res Ther Section Abstract Doc Link PMC1860077 Disease Relevance 0.35 Pain Relevance 0.18
After immunointervention autoantibody titers against all types of oxLDL were decreased in parallel to the increase in high-density lipoprotein-cholesterol and high-density lipoprotein-Lp-PLA2 activity.
Positive_regulation (increase) of high-density lipoprotein
3) Confidence 0.06 Published 2007 Journal Arthritis Res Ther Section Abstract Doc Link PMC1860077 Disease Relevance 0.35 Pain Relevance 0.18
Nicotinic acid (or niacin) has beneficial effects on all traditional blood lipid and lipoprotein fractions, particularly for increasing high-density lipoprotein (HDL)-cholesterol and reducing lipoprotein(a).
Positive_regulation (increasing) of high-density lipoprotein in blood associated with disorder of lipid metabolism
4) Confidence 0.04 Published 2006 Journal Cardiovasc Diabetol Section Body Doc Link PMC1592077 Disease Relevance 0.72 Pain Relevance 0.03
This mixed dyslipidemia (or "lipid quartet"): hypertriglyceridemia, low high-density lipoprotein cholesterol levels, a preponderance of small, dense low-density lipoprotein particles and an accumulation of cholesterol-rich remnant particles (e.g. high levels of apolipoprotein B) – emerged as the greatest "competitor" of low-density lipoprotein-cholesterol among lipid risk factors for cardiovascular disease.
Positive_regulation (accumulation) of high-density lipoprotein associated with cardiovascular disease, hyperlipidemia and disorder of lipid metabolism
5) Confidence 0.03 Published 2006 Journal Cardiovasc Diabetol Section Abstract Doc Link PMC1592077 Disease Relevance 1.20 Pain Relevance 0
This mixed dyslipidemia (or "lipid quartet"): hypertriglyceridemia, low HDL (high-density lipoprotein)-cholesterol levels, a preponderance of small, dense LDL particles and an accumulation of cholesterol-rich remnant particles (e.g. high levels of apolipoprotein B) – emerged as the greatest "competitor" of LDL-cholesterol among lipid risk factors for cardiovascular disease.
Positive_regulation (accumulation) of high-density lipoprotein associated with cardiovascular disease, hyperlipidemia and disorder of lipid metabolism
6) Confidence 0.03 Published 2006 Journal Cardiovasc Diabetol Section Body Doc Link PMC1592077 Disease Relevance 1.31 Pain Relevance 0

General Comments

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