INT179372

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Context Info
Confidence 0.38
First Reported 2004
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 0.35
Pain Relevance 1.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (PTGS2) endoplasmic reticulum (PTGS2) enzyme binding (PTGS2)
protein complex (PTGS2) cytoplasm (PTGS2) lipid binding (PTGS2)
PTGS2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Morphine 83 99.04 Very High Very High Very High
Inflammation 16 96.52 Very High Very High Very High
addiction 3 31.92 Quite Low
Paracetamol 26 5.00 Very Low Very Low Very Low
Pain 6 5.00 Very Low Very Low Very Low
cINOD 4 5.00 Very Low Very Low Very Low
adenocard 4 5.00 Very Low Very Low Very Low
depression 3 5.00 Very Low Very Low Very Low
corticosteroid 2 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 22 96.52 Very High Very High Very High
Disease 10 5.00 Very Low Very Low Very Low
Aging 6 5.00 Very Low Very Low Very Low
Pain 6 5.00 Very Low Very Low Very Low
Body Weight 6 5.00 Very Low Very Low Very Low
Arthropathy 6 5.00 Very Low Very Low Very Low
Injury 5 5.00 Very Low Very Low Very Low
Stress 5 5.00 Very Low Very Low Very Low
Acquired Immune Deficiency Syndrome Or Hiv Infection 4 5.00 Very Low Very Low Very Low
Wasting Syndrome 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interestingly, reaction mixtures containing a typical peak morphine concentration (450 ng/ml) showed a significant increase in histamine release in the presence of prostaglandin H synthetase compared with no enzyme.
Positive_regulation (increase) of Localization (release) of prostaglandin H synthetase associated with morphine
1) Confidence 0.38 Published 2004 Journal BMC Pharmacol Section Body Doc Link PMC526189 Disease Relevance 0 Pain Relevance 1.04
The question of how in the presence of adequate PUFA precursors the constitutive and inducible forms of prostaglandin H synthetase can be induced to generate the appropriate forms of prostaglandin required to maintain tissue homeostasis will rely on further understanding of the co-factors and feedback mechanisms involved.
Positive_regulation (inducible) of Localization (forms) of prostaglandin H synthetase
2) Confidence 0.02 Published 2007 Journal Nutr Metab (Lond) Section Body Doc Link PMC2198910 Disease Relevance 0.18 Pain Relevance 0.09
The question of how in the presence of adequate PUFA precursors the constitutive and inducible forms of prostaglandin H synthetase can be induced to generate the appropriate forms of prostaglandin required to maintain tissue homeostasis will rely on further understanding of the co-factors and feedback mechanisms involved.
Positive_regulation (induced) of Localization (forms) of prostaglandin H synthetase
3) Confidence 0.02 Published 2007 Journal Nutr Metab (Lond) Section Body Doc Link PMC2198910 Disease Relevance 0.17 Pain Relevance 0.09

General Comments

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