INT179373

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Context Info
Confidence 0.20
First Reported 2004
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.97
Pain Relevance 0.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (XDH) small molecule metabolic process (XDH) extracellular region (XDH)
peroxisome (XDH) cytoplasm (XDH)
Anatomy Link Frequency
renal tubule 1
XDH (Homo sapiens)
Pain Link Frequency Relevance Heat
alcohol 2 98.58 Very High Very High Very High
corticosteroid 1 98.08 Very High Very High Very High
aspirin 1 97.30 Very High Very High Very High
Bioavailability 1 94.96 High High
Morphine 83 84.72 Quite High
Arthritis 2 43.24 Quite Low
withdrawal 1 42.24 Quite Low
adenocard 7 5.00 Very Low Very Low Very Low
addiction 6 5.00 Very Low Very Low Very Low
depression 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Syndrome 3 100.00 Very High Very High Very High
Hyponatremia 2 99.92 Very High Very High Very High
Iron Overload 1 99.36 Very High Very High Very High
Disease 16 99.02 Very High Very High Very High
Liver Disease 1 98.40 Very High Very High Very High
Leukopenia 1 97.52 Very High Very High Very High
Death 1 93.24 High High
Crystal Associated Disease 23 92.80 High High
Schizophrenia 37 86.56 High High
Hypersensitivity 19 71.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Reduced levels of UA are seen with a variety of medications (allopurinol, aspirin, probenacid, coumadin, corticosteroids), liver disease, alcohol use, Wilson's disease, hemochromatosis, protein or purine deficiency, xanthine oxidase deficiency, syndrome of inappropriate ADH secretion (SIADH) or renal tubule disease [58].
Localization (secretion) of xanthine oxidase in renal tubule associated with hyponatremia, aspirin, corticosteroid, syndrome, iron overload, disease, alcohol and liver disease
1) Confidence 0.20 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2831068 Disease Relevance 1.10 Pain Relevance 0.15
Other enzyme systems (horseradish peroxidase/ hydrogen peroxide and hypoxanthine/ xanthine oxidase) did release histamine in our model (results not shown), but they produced excess background interference in the chromatograms and made identification of peaks difficult.
Localization (release) of xanthine oxidase
2) Confidence 0.11 Published 2004 Journal BMC Pharmacol Section Body Doc Link PMC526189 Disease Relevance 0 Pain Relevance 0.34
Azathioprine is converted into mercaptopurine that is metabolized by xanthine oxidase into inactive compounds, so the concomitant enzyme inhibition by allopurinol causes a conspicuous increase of mercaptopurine bioavailability, myelotoxicity and risk of death.
Neg (inactive) Localization (metabolized) of xanthine oxidase associated with death and bioavailability
3) Confidence 0.06 Published 2007 Journal International Journal of Medical Sciences Section Body Doc Link PMC1838823 Disease Relevance 0.87 Pain Relevance 0.05

General Comments

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