INT17938

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Context Info
Confidence 0.48
First Reported 1982
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 28
Total Number 38
Disease Relevance 11.17
Pain Relevance 13.62

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Cpe) extracellular space (Cpe) Golgi apparatus (Cpe)
Anatomy Link Frequency
Heart 3
spinal cord 2
facet 1
striatum 1
autonomic 1
Cpe (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Enkephalin 59 100.00 Very High Very High Very High
headache 54 100.00 Very High Very High Very High
Cluster headache 16 100.00 Very High Very High Very High
Morphine 10 100.00 Very High Very High Very High
Neuropeptide 30 99.96 Very High Very High Very High
Trigeminal neuralgia 3 99.80 Very High Very High Very High
Kinase C 165 99.44 Very High Very High Very High
Spinal cord 10 99.28 Very High Very High Very High
Opioid 15 96.40 Very High Very High Very High
syringomyelia 1 95.16 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hyperplasia 400 100.00 Very High Very High Very High
Osteoarthritis 212 100.00 Very High Very High Very High
Paroxysmal Hemicrania 33 100.00 Very High Very High Very High
Cluster Headache 16 100.00 Very High Very High Very High
Headache 20 99.80 Very High Very High Very High
Hydrocephalus 1 99.76 Very High Very High Very High
Diabetes Mellitus 8 99.48 Very High Very High Very High
Natriuresis 7 98.92 Very High Very High Very High
Congenital Anomalies 2 98.88 Very High Very High Very High
Tics 4 98.08 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The noncompetitive inhibition by morphine of [3H]leucine enkephalin binding was shown to be rapidly reversible, ruling out pseudoirreversible binding of morphine to the enkephalin binding site as the underlying mechanism.
enkephalin binding site Binding (binding) of associated with enkephalin and morphine
1) Confidence 0.48 Published 1982 Journal Mol. Pharmacol. Section Abstract Doc Link 7110115 Disease Relevance 0 Pain Relevance 1.57
Heart homogenates bind [3H]guanidinoethylmercaptosuccinic acid ([ 3H]GEMSA), a selective ligand for enkephalin convertase, with specificity and high affinity (Kd = 5-10 nM).
convertase Binding (bind) of in Heart associated with enkephalin
2) Confidence 0.40 Published 1988 Journal Endocrinology Section Abstract Doc Link 2967176 Disease Relevance 0.17 Pain Relevance 0.40
Accordingly, we should probably sever the link between CH and CPH and favour, instead, a linking together of CPH and HC, the two principal IRHs.
CPH Binding (link) of associated with cluster headache and headache
3) Confidence 0.37 Published 2010 Journal Funct. Neurol. Section Abstract Doc Link 20626997 Disease Relevance 1.93 Pain Relevance 2.02
Traditionally, CPH has been linked to cluster headache (CH) due to clinical similarities: unilaterality, intensity, and some autonomic phenomena.
CPH Binding (linked) of in autonomic associated with cluster headache and headache
4) Confidence 0.37 Published 2010 Journal Funct. Neurol. Section Abstract Doc Link 20626997 Disease Relevance 1.54 Pain Relevance 1.62
These findings, which are similar to those previously reported in cluster headache, suggest that CPH is associated with an ocular sympathetic deficit and with overactivity in the greater superficial petrosal nerve.
CPH Binding (associated) of in nerve associated with cluster headache and headache
5) Confidence 0.35 Published 1985 Journal Cephalalgia Section Abstract Doc Link 4042152 Disease Relevance 1.22 Pain Relevance 0.96
3H-Guanidinoethylmercaptosuccinic acid (3H-GEMSA) a very selective inhibitor of enkephalin convertase, binds to the crude rat spinal cord homogenates saturably, reversibly and with high affinity.
Enkephalin convertase Binding (binds) of in spinal cord associated with enkephalin and spinal cord
6) Confidence 0.33 Published 1986 Journal Neuropeptides Section Abstract Doc Link 3102993 Disease Relevance 0 Pain Relevance 0.37
3H-Guanidinoethylmercaptosuccinic acid (3H-GEMSA) a very selective inhibitor of enkephalin convertase, binds to the crude rat spinal cord homogenates saturably, reversibly and with high affinity.
enkephalin convertase Binding (binds) of in spinal cord associated with enkephalin and spinal cord
7) Confidence 0.33 Published 1986 Journal Neuropeptides Section Abstract Doc Link 3102993 Disease Relevance 0 Pain Relevance 0.37
Contrary to findings in cluster headache, no typical pattern of heart rate change was found in association with attacks of CPH.
CPH Binding (association) of in heart associated with cluster headache
8) Confidence 0.32 Published 1984 Journal Cephalalgia Section Abstract Doc Link 6733781 Disease Relevance 0.25 Pain Relevance 0.17
Specificity for CPE was confirmed by control experiments, which included production of identical patterns hybridization with 3 different antisense oligonucleotide probes, loss of label with RNase pretreatment of sections or co-incubation with excess unlabeled probe, and lack of labeling with sense orientation probes.
CPE Binding (Specificity) of
9) Confidence 0.31 Published 1990 Journal J. Neurosci. Section Abstract Doc Link 2388090 Disease Relevance 0 Pain Relevance 0.27
Heart homogenates bind [3H]guanidinoethylmercaptosuccinic acid ([ 3H]GEMSA), a selective ligand for enkephalin convertase, with specificity and high affinity (Kd = 5-10 nM).
convertase Binding (ligand) of in Heart associated with enkephalin
10) Confidence 0.29 Published 1988 Journal Endocrinology Section Abstract Doc Link 2967176 Disease Relevance 0.17 Pain Relevance 0.40
Thus, the sorting of proinsulin and proenkephalin to the RSP, like POMC, necessitates binding to CPE, and hence, CPE acts as a common sorting receptor for targeting these prohormones to the RSP.
CPE Binding (binding) of
11) Confidence 0.29 Published 1998 Journal Endocrinology Section Abstract Doc Link 9529003 Disease Relevance 0 Pain Relevance 0
While these results demonstrate the presence of the DAT: CPE protein complex in rat striatal tissue, it does not clarify whether the DAT: CPE protein complex is formed through a direct interaction or is mediated indirectly by an accessory binding protein.
CPE Binding (interaction) of
12) Confidence 0.29 Published 2009 Journal Mol Brain Section Body Doc Link PMC2687442 Disease Relevance 0 Pain Relevance 0
In vitro binding assays were performed to provide evidence that DAT and CPE can directly interact with each other.
CPE Binding (interact) of
13) Confidence 0.29 Published 2009 Journal Mol Brain Section Body Doc Link PMC2687442 Disease Relevance 0 Pain Relevance 0
Previous studies have shown that the prohormone POMC is sorted to the regulated secretory pathway (RSP), at the trans-Golgi network, by binding of a conformation-dependent sorting signal to a sorting receptor, identified as membrane-bound carboxypeptidase E (CPE) (Cool et al., 1997, Cell, 88:73-83).
carboxypeptidase E Binding (binding) of
14) Confidence 0.28 Published 1998 Journal Endocrinology Section Abstract Doc Link 9529003 Disease Relevance 0 Pain Relevance 0
Previous studies have shown that the prohormone POMC is sorted to the regulated secretory pathway (RSP), at the trans-Golgi network, by binding of a conformation-dependent sorting signal to a sorting receptor, identified as membrane-bound carboxypeptidase E (CPE) (Cool et al., 1997, Cell, 88:73-83).
CPE Binding (binding) of
15) Confidence 0.28 Published 1998 Journal Endocrinology Section Abstract Doc Link 9529003 Disease Relevance 0 Pain Relevance 0
Identification and cloning of a granule autoantigen (carboxypeptidase-H) associated with type I diabetes.
carboxypeptidase-H Binding (associated) of associated with diabetes mellitus
16) Confidence 0.28 Published 1991 Journal J. Clin. Endocrinol. Metab. Section Title Doc Link 1955501 Disease Relevance 0.23 Pain Relevance 0.09
In many cases, as a final step in the biosynthesis of neuropeptides, CPE recognizes and cleaves the Arg/Lys paired basic residues at the COOH-terminal side to generate the final neuropeptide.
CPE Binding (recognizes) of associated with neuropeptide
17) Confidence 0.25 Published 2009 Journal Mol Brain Section Body Doc Link PMC2687442 Disease Relevance 0 Pain Relevance 0.10
As shown in Fig 1B, GST-DAT-NT was unable to precipitate CPE, strongly suggesting that the interaction between DAT and CPE is mediated specifically by the DAT-CT.
CPE Binding (interaction) of
18) Confidence 0.23 Published 2009 Journal Mol Brain Section Body Doc Link PMC2687442 Disease Relevance 0 Pain Relevance 0.03
As shown in Figure 1C, in vitro translated [35S]-CPE probe hybridized with GST-DAT-CT but not GST-DAT-NT or GST alone, indicating the specificity of the direct protein-protein interaction between CPE and DAT-CT.
CPE Binding (interaction) of
19) Confidence 0.23 Published 2009 Journal Mol Brain Section Body Doc Link PMC2687442 Disease Relevance 0 Pain Relevance 0
While these results demonstrate the presence of the DAT: CPE protein complex in rat striatal tissue, it does not clarify whether the DAT: CPE protein complex is formed through a direct interaction or is mediated indirectly by an accessory binding protein.
CPE Binding (complex) of
20) Confidence 0.23 Published 2009 Journal Mol Brain Section Body Doc Link PMC2687442 Disease Relevance 0 Pain Relevance 0.03

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