INT179391

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Context Info
Confidence 0.02
First Reported 2004
Last Reported 2004
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 14
Disease Relevance 7.01
Pain Relevance 3.89

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Map2k2) mitochondrion (Map2k2) Golgi apparatus (Map2k2)
nucleus (Map2k2)
Anatomy Link Frequency
brain 3
neocortex 2
hippocampus 2
striatum 1
amygdala 1
Map2k2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Hippocampus 308 99.68 Very High Very High Very High
amygdala 168 98.28 Very High Very High Very High
analgesia 14 97.44 Very High Very High Very High
nMDA receptor 70 90.64 High High
anesthesia 14 82.80 Quite High
halothane 14 82.04 Quite High
Catecholamine 14 81.20 Quite High
Dopamine 14 68.60 Quite High
Glutamate receptor 14 45.76 Quite Low
Visceral pain 28 35.80 Quite Low
Disease Link Frequency Relevance Heat
Stress 938 99.44 Very High Very High Very High
Sprains And Strains 14 76.48 Quite High
Anxiety Disorder 28 70.32 Quite High
Depressive Disorder 14 69.36 Quite High
Shock 28 37.12 Quite Low
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super / Visceral Pain

28 35.80 Quite Low
Convulsion 14 33.72 Quite Low
Apoptosis 14 31.56 Quite Low
INFLAMMATION 14 31.00 Quite Low
Depression 56 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, the magnitude of the increase in phosphorylation of MEK1/2 and MKK4 was much greater than for their cognate substrates.
Phosphorylation (phosphorylation) of MEK1/2
1) Confidence 0.02 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC526203 Disease Relevance 0.59 Pain Relevance 0.34
The effect of varying the duration of swim on the phosphorylation of MEK1/2 and MKK4 was examined in neocortex and hippocampus.
Phosphorylation (phosphorylation) of MEK1/2 in hippocampus associated with hippocampus
2) Confidence 0.02 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC526203 Disease Relevance 0.36 Pain Relevance 0.28
The present study followed up that investigation by examining the effects of a different common stressor, forced swim stress, extended the number of brain areas examined, and also evaluated changes in the phosphorylation state of the respective upstream MAPKK activators MEK1/2, MKK4 (also known as SEK1 and JNKK) and MKK3/6.
Phosphorylation (phosphorylation) of MEK1/2 in brain associated with stress
3) Confidence 0.02 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC526203 Disease Relevance 0.74 Pain Relevance 0.17
An acute 15 min session of forced swimming produced obvious large increases in the phosphorylation of the MAPKK MEK1/2 in the hippocampus, neocortex, prefrontal cortex, amygdala and striatum (Fig. 1, top).
Phosphorylation (phosphorylation) of MEK1/2 in prefrontal associated with hippocampus and amygdala
4) Confidence 0.02 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC526203 Disease Relevance 0.62 Pain Relevance 0.28
A final alternative hypothesis is that swim stress activates a mechanism that serves to uncouple MEK1/2 phosphorylation (fully or in part) from activation of Erk.
Phosphorylation (phosphorylation) of MEK1/2 associated with stress
5) Confidence 0.02 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC526203 Disease Relevance 0.29 Pain Relevance 0.03
Surprisingly, phosphorylation of the substrate(s) of activated MEK1/2, Erk1/2, was increased to a much smaller extent, and in some brain regions (hippocampus, amygdala) not at all (Fig. 1, bottom).
Phosphorylation (phosphorylation) of MEK1/2 in brain associated with hippocampus and amygdala
6) Confidence 0.02 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC526203 Disease Relevance 0.59 Pain Relevance 0.29
Acute swim stress initiated a rapid increase in phosphorylation of the MAPKKs MEK1/2 and MKK4 in hippocampus, neocortex, prefrontal cortex, amygdala and striatum.
Phosphorylation (phosphorylation) of MEK1/2 in striatum associated with stress, hippocampus and amygdala
7) Confidence 0.02 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC526203 Disease Relevance 0.49 Pain Relevance 0.44
Swim stress elicits large increases in phosphorylation of MEK1/2 in all brain regions
Phosphorylation (phosphorylation) of MEK1/2 in brain associated with stress
8) Confidence 0.02 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC526203 Disease Relevance 0.69 Pain Relevance 0.25
Thus, one may posit that kinases (e.g., MEK1/2, MKK4) whose basal state of phosphorylation is very low may be subject to large increases, whereas those whose basal state is comparatively larger (e.g., Erk, JNK) demonstrate much smaller increases.
Phosphorylation (phosphorylation) of MEK1/2
9) Confidence 0.01 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC526203 Disease Relevance 0.06 Pain Relevance 0.09
Acute swim stress initiated a rapid increase in phosphorylation of the MAPKKs MEK1/2 and MKK4 in hippocampus, neocortex, prefrontal cortex, amygdala and striatum.
Phosphorylation (phosphorylation) of MEK1/2 in amygdala associated with stress, hippocampus and amygdala
10) Confidence 0.01 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC526203 Disease Relevance 0.49 Pain Relevance 0.44
An acute 15 min session of forced swimming produced obvious large increases in the phosphorylation of the MAPKK MEK1/2 in the hippocampus, neocortex, prefrontal cortex, amygdala and striatum (Fig. 1, top).
Phosphorylation (phosphorylation) of MEK1/2 in neocortex associated with hippocampus and amygdala
11) Confidence 0.01 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC526203 Disease Relevance 0.62 Pain Relevance 0.28
An acute 15 min session of forced swimming produced obvious large increases in the phosphorylation of the MAPKK MEK1/2 in the hippocampus, neocortex, prefrontal cortex, amygdala and striatum (Fig. 1, top).
Phosphorylation (phosphorylation) of MEK1/2 in hippocampus associated with hippocampus and amygdala
12) Confidence 0.01 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC526203 Disease Relevance 0.62 Pain Relevance 0.28
Acute swim stress initiated a rapid increase in phosphorylation of the MAPKKs MEK1/2 and MKK4 in hippocampus, neocortex, prefrontal cortex, amygdala and striatum.
Phosphorylation (phosphorylation) of MEK1/2 in cortex associated with stress, hippocampus and amygdala
13) Confidence 0.01 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC526203 Disease Relevance 0.49 Pain Relevance 0.44
The effect of varying the duration of swim on the phosphorylation of MEK1/2 and MKK4 was examined in neocortex and hippocampus.
Phosphorylation (phosphorylation) of MEK1/2 in neocortex associated with hippocampus
14) Confidence 0.01 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC526203 Disease Relevance 0.36 Pain Relevance 0.28

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