INT179393

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Context Info
Confidence 0.03
First Reported 2004
Last Reported 2004
Negated 1
Speculated 1
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0.67
Pain Relevance 0.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
brain 1
Smek1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
amygdala 36 89.40 High High
Hippocampus 66 84.48 Quite High
Catecholamine 3 44.96 Quite Low
nMDA receptor 15 5.00 Very Low Very Low Very Low
depression 9 5.00 Very Low Very Low Very Low
Visceral pain 6 5.00 Very Low Very Low Very Low
Central nervous system 3 5.00 Very Low Very Low Very Low
long-term potentiation 3 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
Inflammation 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 201 100.00 Very High Very High Very High
Depression 12 5.00 Very Low Very Low Very Low
Anxiety Disorder 6 5.00 Very Low Very Low Very Low
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super / Visceral Pain

6 5.00 Very Low Very Low Very Low
Glioma 6 5.00 Very Low Very Low Very Low
Shock 6 5.00 Very Low Very Low Very Low
Depressive Disorder 3 5.00 Very Low Very Low Very Low
Sprains And Strains 3 5.00 Very Low Very Low Very Low
Apoptosis 3 5.00 Very Low Very Low Very Low
Decapitation 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, Liu et al. [38] did not determine the effects of swim stress on P-MEK1/2 levels (which we found were also markedly elevated: Figs. 1 and 2).
Neg (not) Spec (determine) Regulation (effects) of P-MEK1 associated with stress
1) Confidence 0.03 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC526203 Disease Relevance 0.35 Pain Relevance 0.11
However, the activity of P-MEK1/2 is regulated by a negative feedback mechanism involving activation of protein phosphatase(s) that rapidly dephosphorylate P-Erk1/2 [44].
Regulation (regulated) of P-MEK1
2) Confidence 0.01 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC526203 Disease Relevance 0.16 Pain Relevance 0.08
Analogous to its effects on P-MEK1/2, but much more dramatically, forced swimming enhanced the levels of P-MKK4, the immediate upstream activator of JNK, in all brain areas tested (Fig. 3, top).
Regulation (effects) of P-MEK1 in brain
3) Confidence 0.01 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC526203 Disease Relevance 0.16 Pain Relevance 0.25

General Comments

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