INT179396

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Context Info
Confidence 0.30
First Reported 2004
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 2.84
Pain Relevance 2.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Map2k2) mitochondrion (Map2k2) Golgi apparatus (Map2k2)
nucleus (Map2k2)
Anatomy Link Frequency
brain 1
striatum 1
amygdala 1
cortex 1
Map2k2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Hippocampus 157 99.48 Very High Very High Very High
Pain 60 98.24 Very High Very High Very High
analgesia 6 97.92 Very High Very High Very High
amygdala 72 97.76 Very High Very High Very High
imagery 7 92.08 High High
nMDA receptor 31 91.12 High High
Nerve growth factor 1 89.36 High High
Glutamate receptor 7 87.64 High High
Spinal cord 35 72.32 Quite High
Dopamine 6 69.08 Quite High
Disease Link Frequency Relevance Heat
Stress 402 99.62 Very High Very High Very High
Pain 82 98.24 Very High Very High Very High
Nociception 14 84.72 Quite High
Anxiety Disorder 12 47.12 Quite Low
Depressive Disorder 6 46.16 Quite Low
Shock 12 13.48 Low Low
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super / Visceral Pain

12 12.16 Low Low
Convulsion 6 10.08 Low Low
Apoptosis 6 7.92 Low Low
INFLAMMATION 10 7.36 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We suggest, to some extent, that it maybe due to the differential activation and regulation of upstream activators for ERK1 and ERK2 (MEK1 or MEK2, for example) in different areas under the pain states.
Positive_regulation (activators) of MEK2 associated with pain
1) Confidence 0.30 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1949833 Disease Relevance 0.47 Pain Relevance 0.73
Thus, a large increase in MEK1/2 phosphorylation/activation would be expected to translate into substantial phosphorylation/activation of Erk.
Positive_regulation (activation) of MEK1/2
2) Confidence 0.01 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC526203 Disease Relevance 0.17 Pain Relevance 0.11
Acute swim stress initiated a rapid increase in phosphorylation of the MAPKKs MEK1/2 and MKK4 in hippocampus, neocortex, prefrontal cortex, amygdala and striatum.
Positive_regulation (increase) of MEK1/2 in striatum associated with stress, hippocampus and amygdala
3) Confidence 0.01 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC526203 Disease Relevance 0.49 Pain Relevance 0.44
A gradual increase in P-Erk2 and P-JNK phosphorylation, subsequent to activation of MEK1/2 and MKK4, may have been obscured by the fact that animals were sacrificed immediately after termination of the swim.
Positive_regulation (activation) of MEK1/2
4) Confidence 0.01 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC526203 Disease Relevance 0.15 Pain Relevance 0.10
Surprisingly, phosphorylation of the substrate(s) of activated MEK1/2, Erk1/2, was increased to a much smaller extent, and in some brain regions (hippocampus, amygdala) not at all (Fig. 1, bottom).
Positive_regulation (activated) of MEK1/2 in brain associated with hippocampus and amygdala
5) Confidence 0.01 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC526203 Disease Relevance 0.58 Pain Relevance 0.29
Acute swim stress initiated a rapid increase in phosphorylation of the MAPKKs MEK1/2 and MKK4 in hippocampus, neocortex, prefrontal cortex, amygdala and striatum.
Positive_regulation (increase) of MEK1/2 in cortex associated with stress, hippocampus and amygdala
6) Confidence 0.00 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC526203 Disease Relevance 0.49 Pain Relevance 0.44
Acute swim stress initiated a rapid increase in phosphorylation of the MAPKKs MEK1/2 and MKK4 in hippocampus, neocortex, prefrontal cortex, amygdala and striatum.
Positive_regulation (increase) of MEK1/2 in amygdala associated with stress, hippocampus and amygdala
7) Confidence 0.00 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC526203 Disease Relevance 0.49 Pain Relevance 0.44

General Comments

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