INT179397

Context Info Confidence 0.01 First Reported 2004 Last Reported 2004 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.17 Pain Relevance 0.11

cytosol (Map2k2) mitochondrion (Map2k2) Golgi apparatus (Map2k2) nucleus (Map2k2)

Map2k2 (Rattus norvegicus)

Pain Link Frequency Relevance Heat amygdala 12 86.28 Hippocampus 22 85.76 Catecholamine 1 51.12 nMDA receptor 5 5.00 depression 3 5.00 Visceral pain 2 5.00 Central nervous system 1 5.00 long-term potentiation 1 5.00 anesthesia 1 5.00 Inflammation 1 5.00

Disease Link Frequency Relevance Heat Stress 67 89.48 Depression 4 5.00 Anxiety Disorder 2 5.00 Irritable Bowel Syndrome / Irritable Bowel Syndrome Super / Visceral Pain 2 5.00 Glioma 2 5.00 Shock 2 5.00 Depressive Disorder 1 5.00 Sprains And Strains 1 5.00 Apoptosis 1 5.00 Decapitation 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Thus, a large increase in MEK1/2 phosphorylation/activation would be expected to translate into substantial phosphorylation/activation of Erk.

Positive_regulation (increase) of Positive_regulation (activation) of MEK1/2

1) Confidence 0.01 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC526203 Disease Relevance 0.17 Pain Relevance 0.11

General Comments

This test has worked.