INT1794

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Context Info
Confidence 0.57
First Reported 1975
Last Reported 2010
Negated 10
Speculated 14
Reported most in Abstract
Documents 136
Total Number 150
Disease Relevance 13.39
Pain Relevance 59.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (CGA) small molecule metabolic process (CGA) extracellular region (CGA)
cellular nitrogen compound metabolic process (CGA) cell-cell signaling (CGA)
Anatomy Link Frequency
pituitary 20
gonadal 16
brain 10
follicle 10
neural 6
CGA (Homo sapiens)
Pain Link Frequency Relevance Heat
narcan 398 100.00 Very High Very High Very High
Opioid 188 100.00 Very High Very High Very High
opiate 139 100.00 Very High Very High Very High
Morphine 81 100.00 Very High Very High Very High
Endogenous opioid 74 100.00 Very High Very High Very High
agonist 66 100.00 Very High Very High Very High
Dopamine 59 100.00 Very High Very High Very High
Serotonin 35 100.00 Very High Very High Very High
Dynorphin 22 100.00 Very High Very High Very High
Enkephalin 11 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hot Flashes 6 100.00 Very High Very High Very High
Congenital Anomalies 7 99.84 Very High Very High Very High
Aging 9 99.48 Very High Very High Very High
Polycystic Ovary Syndrome 13 99.42 Very High Very High Very High
Syndrome 38 99.40 Very High Very High Very High
Eating Disorder 7 99.28 Very High Very High Very High
Body Weight 19 99.24 Very High Very High Very High
Stress 205 99.00 Very High Very High Very High
Anovulation 2 98.96 Very High Very High Very High
Opiate Addiction 2 98.50 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Recently, the involvement of endogenous opioid peptides (EOP) in the control of the neuroendocrine mechanism modulating gonadotrophin secretion has been supported by several authors.
Regulation (control) of Localization (secretion) of gonadotrophin associated with endogenous opioid
1) Confidence 0.57 Published 1993 Journal Hum. Reprod. Section Abstract Doc Link 8276950 Disease Relevance 0.15 Pain Relevance 0.44
Opioid control of gonadotrophin secretion in humans.
Regulation (control) of Localization (secretion) of gonadotrophin associated with opioid
2) Confidence 0.57 Published 1993 Journal Hum. Reprod. Section Title Doc Link 8276950 Disease Relevance 0.15 Pain Relevance 0.46
Effect of naloxone on gonadotropin secretion before and after testosterone in Klinefelter's syndrome.
Regulation (Effect) of Localization (secretion) of gonadotropin associated with syndrome and narcan
3) Confidence 0.54 Published 1985 Journal Psychoneuroendocrinology Section Title Doc Link 3933025 Disease Relevance 0.19 Pain Relevance 0.52
Gonadal steroids and opioid control of gonadotropin secretion in man.
Regulation (control) of Localization (secretion) of gonadotropin in Gonadal associated with narcan and opioid
4) Confidence 0.52 Published 1983 Journal Fertil. Steril. Section Title Doc Link 6317469 Disease Relevance 0 Pain Relevance 0.59
The involvement of DYN in physiological control of placental hCG secretion is suggested.
Regulation (control) of Localization (secretion) of hCG associated with dynorphin
5) Confidence 0.51 Published 1991 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 1682338 Disease Relevance 0 Pain Relevance 0.76
The bell shaped response curves for agonists and antagonists suggest that opioids play a role in the regulation of hCG release from trophoblast tissue, but other mechanism(s) may also exist.
Regulation (regulation) of Localization (release) of hCG associated with antagonist, agonist and opioid
6) Confidence 0.50 Published 1991 Journal Life Sci. Section Abstract Doc Link 1652048 Disease Relevance 0 Pain Relevance 0.99
Opioid ligands were investigated for their effect on hCG release from trophoblast tissue obtained from term human placenta.
Spec (investigated) Regulation (effect) of Localization (release) of hCG in placenta associated with opioid
7) Confidence 0.50 Published 1991 Journal Life Sci. Section Abstract Doc Link 1652048 Disease Relevance 0 Pain Relevance 0.73
Endogenous opiates participate in the regulation of pulsatile luteinizing hormone release in an unopposed estrogen milieu: studies in estrogen-replaced, gonadectomized patients with testicular feminization.
Regulation (regulation) of Localization (release) of luteinizing hormone associated with narcan, opiate and androgen insensitivity
8) Confidence 0.50 Published 1985 Journal J. Clin. Endocrinol. Metab. Section Title Doc Link 4031019 Disease Relevance 0.19 Pain Relevance 0.57
Amenorrhea is commonly associated with methadone ingestion or heroin addiction and appears to be related to an alteration of the hypothalamic mechanisms controlling gonadotropin secretion.
Regulation (controlling) of Localization (secretion) of gonadotropin associated with addiction, methadone, opiate addiction and reprotox - general 1
9) Confidence 0.48 Published 1975 Journal Fertil. Steril. Section Abstract Doc Link 236938 Disease Relevance 0.50 Pain Relevance 0.39
Four of the seven women manifested abnormalities of the control of gonadotropin secretion.
Regulation (control) of Localization (secretion) of gonadotropin associated with congenital anomalies
10) Confidence 0.48 Published 1975 Journal Fertil. Steril. Section Abstract Doc Link 236938 Disease Relevance 0.53 Pain Relevance 0.51
Based on these results we assume that opiates may have a role in the local (autocrine and/or paracrine) regulation of hCG secretion in early gestation.
Regulation (role) of Localization (secretion) of hCG associated with opiate
11) Confidence 0.46 Published 1988 Journal Life Sci. Section Abstract Doc Link 3362038 Disease Relevance 0 Pain Relevance 0.66
Effect of beta-endorphin on human chorionic gonadotrophin secretion by placental explants.
Regulation (Effect) of Localization (secretion) of chorionic gonadotrophin associated with narcan
12) Confidence 0.44 Published 1991 Journal Hum. Reprod. Section Title Doc Link 1661290 Disease Relevance 0 Pain Relevance 0.53
CONCLUSION: Endogenous catecholamines augment the inhibitory effect of opioids on luteinizing hormone secretion during the midluteal phase in normal cycling women.


Regulation (effect) of Localization (secretion) of luteinizing hormone
13) Confidence 0.42 Published 1993 Journal Am. J. Obstet. Gynecol. Section Body Doc Link 7903508 Disease Relevance 0 Pain Relevance 0
These data indicate a probable role for PGE2 or other prostanoids as well in the regulation of human PRL release but not in gonadotrophin secretion.
Spec (probable) Regulation (role) of Neg (not) Localization (secretion) of gonadotrophin
14) Confidence 0.40 Published 1992 Journal Eicosanoids Section Abstract Doc Link 1419076 Disease Relevance 0.08 Pain Relevance 0.24
These data indicate a probable role for PGE2 or other prostanoids as well in the regulation of human PRL release but not in gonadotrophin secretion.
Neg (not) Regulation (regulation) of Neg (not) Localization (secretion) of gonadotrophin
15) Confidence 0.40 Published 1992 Journal Eicosanoids Section Abstract Doc Link 1419076 Disease Relevance 0.07 Pain Relevance 0.23
In addition, placental kappa receptors mediate opioid regulation of hCG release from trophoblast tissue in vitro and placental GnRH plays a role in regulation of hCG secretion as well.
Regulation (regulation) of Localization (release) of hCG associated with opioid
16) Confidence 0.38 Published 1994 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8114013 Disease Relevance 0 Pain Relevance 0.58
These data suggest that in vitro opioids regulation of hCG release from term trophoblast tissue is mediated by GnRH.
Regulation (regulation) of Localization (release) of hCG associated with opioid
17) Confidence 0.38 Published 1994 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8114013 Disease Relevance 0 Pain Relevance 0.74
In the hypothalamic-pituitary axis opioid regulation of luteinizing hormone secretion occurs via gonadotropin hormone-releasing hormone (GnRH).
Regulation (regulation) of Localization (secretion) of luteinizing hormone in pituitary associated with opioid
18) Confidence 0.38 Published 1994 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8114013 Disease Relevance 0 Pain Relevance 0.36
The purpose of this investigation was to determine whether opioids regulation of hCG release from trophoblast tissue is mediated by GnRH.
Spec (whether) Regulation (regulation) of Localization (release) of hCG associated with opioid
19) Confidence 0.38 Published 1994 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8114013 Disease Relevance 0 Pain Relevance 0.73
The effects of naloxone (20 mg, intravenously) and of a met-enkephalin analog (DAMME) (250 micrograms, intravenously) on gonadotropin secretion in three castrated men (18 to 23 years of age) and in five age-matched normal men were studied.
Regulation (effects) of Localization (secretion) of gonadotropin associated with narcan and enkephalin
20) Confidence 0.38 Published 1983 Journal Fertil. Steril. Section Abstract Doc Link 6317469 Disease Relevance 0 Pain Relevance 0.47

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