INT179400

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Context Info
Confidence 0.30
First Reported 2004
Last Reported 2004
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.01
Pain Relevance 0.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Map2k4) nucleus (Map2k4)
Anatomy Link Frequency
neocortex 3
hippocampus 1
Map2k4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Hippocampus 44 100.00 Very High Very High Very High
anesthesia 2 72.28 Quite High
halothane 2 71.52 Quite High
amygdala 24 55.88 Quite High
nMDA receptor 10 5.00 Very Low Very Low Very Low
depression 6 5.00 Very Low Very Low Very Low
Visceral pain 4 5.00 Very Low Very Low Very Low
Central nervous system 2 5.00 Very Low Very Low Very Low
long-term potentiation 2 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 134 100.00 Very High Very High Very High
Sprains And Strains 2 65.96 Quite High
Depression 8 5.00 Very Low Very Low Very Low
Anxiety Disorder 4 5.00 Very Low Very Low Very Low
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super / Visceral Pain

4 5.00 Very Low Very Low Very Low
Glioma 4 5.00 Very Low Very Low Very Low
Shock 4 5.00 Very Low Very Low Very Low
Depressive Disorder 2 5.00 Very Low Very Low Very Low
Apoptosis 2 5.00 Very Low Very Low Very Low
Decapitation 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The levels of P-MEK1/2 and P-MKK4 in both neocortex and hippocampus were maximal immediately after termination of swim stress (Fig. 9, top), declined gradually, and all except P-MKK4 in neocortex returned to basal levels by 60 min.
Negative_regulation (declined) of Gene_expression (levels) of MKK4 in neocortex associated with stress and hippocampus
1) Confidence 0.30 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC526203 Disease Relevance 0.50 Pain Relevance 0.26
The levels of P-MEK1/2 and P-MKK4 in both neocortex and hippocampus were maximal immediately after termination of swim stress (Fig. 9, top), declined gradually, and all except P-MKK4 in neocortex returned to basal levels by 60 min.
Negative_regulation (declined) of in hippocampus Gene_expression (levels) of MKK4 in neocortex associated with stress and hippocampus
2) Confidence 0.10 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC526203 Disease Relevance 0.50 Pain Relevance 0.26

General Comments

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