INT179412

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Context Info
Confidence 0.26
First Reported 2004
Last Reported 2004
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 1.98
Pain Relevance 0.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
brain 1
Map2k6 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Hippocampus 66 91.96 High High
amygdala 36 74.44 Quite High
nMDA receptor 15 5.00 Very Low Very Low Very Low
depression 9 5.00 Very Low Very Low Very Low
Visceral pain 6 5.00 Very Low Very Low Very Low
Central nervous system 3 5.00 Very Low Very Low Very Low
long-term potentiation 3 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
Inflammation 3 5.00 Very Low Very Low Very Low
ischemia 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 201 99.64 Very High Very High Very High
Glioma 6 95.48 Very High Very High Very High
Depression 12 5.00 Very Low Very Low Very Low
Anxiety Disorder 6 5.00 Very Low Very Low Very Low
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super / Visceral Pain

6 5.00 Very Low Very Low Very Low
Shock 6 5.00 Very Low Very Low Very Low
Depressive Disorder 3 5.00 Very Low Very Low Very Low
Sprains And Strains 3 5.00 Very Low Very Low Very Low
Apoptosis 3 5.00 Very Low Very Low Very Low
Decapitation 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It seems likely, therefore, that basal levels of brain P-MKK3/6 are very low (cf. basal levels of P-MKK4, Fig. 3), and, unlike P-MEK1/2 and P-MKK4, are not induced by swim stress.
Neg (not) Positive_regulation (induced) of MKK3 in brain associated with stress
1) Confidence 0.26 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC526203 Disease Relevance 0.70 Pain Relevance 0.10
Since the major activators of p38MAPK are the closely related, dual specificity kinases phosphorylated MKK3 and MKK6 [39], we attempted to determine if swim stress increased the phosphorylation of this upstream kinase.
Positive_regulation (activators) of MKK6 associated with stress
2) Confidence 0.26 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC526203 Disease Relevance 0.64 Pain Relevance 0.12
Since the major activators of p38MAPK are the closely related, dual specificity kinases phosphorylated MKK3 and MKK6 [39], we attempted to determine if swim stress increased the phosphorylation of this upstream kinase.
Positive_regulation (activators) of MKK3 associated with stress
3) Confidence 0.11 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC526203 Disease Relevance 0.64 Pain Relevance 0.12

General Comments

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