INT179415

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Context Info
Confidence 0.47
First Reported 2004
Last Reported 2004
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 2.08
Pain Relevance 0.85

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Map2k4) nucleus (Map2k4)
Anatomy Link Frequency
neocortex 1
brain 1
hippocampus 1
Map2k4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Hippocampus 88 99.08 Very High Very High Very High
amygdala 48 93.48 High High
anesthesia 4 72.28 Quite High
halothane 4 71.52 Quite High
Visceral pain 8 52.96 Quite High
ischemia 4 52.36 Quite High
nMDA receptor 20 5.00 Very Low Very Low Very Low
depression 12 5.00 Very Low Very Low Very Low
Central nervous system 4 5.00 Very Low Very Low Very Low
long-term potentiation 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 268 98.40 Very High Very High Very High
Sprains And Strains 4 65.96 Quite High
Shock 8 54.08 Quite High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super / Visceral Pain

8 52.96 Quite High
Cv Unclassified Under Development 4 52.36 Quite High
Depression 16 5.00 Very Low Very Low Very Low
Anxiety Disorder 8 5.00 Very Low Very Low Very Low
Glioma 8 5.00 Very Low Very Low Very Low
Depressive Disorder 4 5.00 Very Low Very Low Very Low
Apoptosis 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interestingly, Liu et al. [38] reported that restraint, like swim, elevated both P-MKK4 and P-JNK levels in mice, but the effects in the former stress model were smaller than in the latter.
Gene_expression (levels) of MKK4 associated with stress
1) Confidence 0.47 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC526203 Disease Relevance 0.66 Pain Relevance 0.09
The levels of P-MEK1/2 and P-MKK4 in both neocortex and hippocampus were maximal immediately after termination of swim stress (Fig. 9, top), declined gradually, and all except P-MKK4 in neocortex returned to basal levels by 60 min.
Gene_expression (levels) of MKK4 in neocortex associated with stress and hippocampus
2) Confidence 0.42 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC526203 Disease Relevance 0.43 Pain Relevance 0.26
Surprisingly, levels of the phosphorylated MAPKKs, P-MEK1/2 and P-MKK4 (activators of the Erk and JNK pathways, respectively) were increased in all five brain regions, and much more dramatically (P-MEK1/2, 4.5 to > 100-fold; P-MKK4, 12 to ~300-fold).
Gene_expression (levels) of MKK4 in brain
3) Confidence 0.42 Published 2004 Journal BMC Neurosci Section Abstract Doc Link PMC526203 Disease Relevance 0.51 Pain Relevance 0.24
The levels of P-MEK1/2 and P-MKK4 in both neocortex and hippocampus were maximal immediately after termination of swim stress (Fig. 9, top), declined gradually, and all except P-MKK4 in neocortex returned to basal levels by 60 min.
Gene_expression (levels) of MKK4 in hippocampus associated with stress and hippocampus
4) Confidence 0.14 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC526203 Disease Relevance 0.43 Pain Relevance 0.26

General Comments

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