INT179420

Context Info Confidence 0.01 First Reported 2004 Last Reported 2004 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 4 Disease Relevance 2.17 Pain Relevance 1.58

cytosol (Map2k2) mitochondrion (Map2k2) Golgi apparatus (Map2k2) nucleus (Map2k2)

Anatomy Link Frequency striatum 4 brain 2 amygdala 1 cortex 1 Map2k2 (Rattus norvegicus)

Pain Link Frequency Relevance Heat Hippocampus 88 99.48 analgesia 4 97.92 amygdala 48 97.76 nMDA receptor 20 91.12 Dopamine 4 69.08 Glutamate receptor 4 46.24 Neurotransmitter 4 33.72 Visceral pain 8 24.92 Inflammation 4 20.12 depression 12 5.00

Disease Link Frequency Relevance Heat Stress 268 99.70 Anxiety Disorder 8 47.12 Depressive Disorder 4 46.16 Shock 8 26.24 Irritable Bowel Syndrome / Irritable Bowel Syndrome Super / Visceral Pain 8 24.92 Convulsion 4 22.84 Apoptosis 4 20.68 INFLAMMATION 4 20.12 Depression 16 5.00 Glioma 8 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Swim stress elicits large increases in phosphorylation of MEK1/2 in all brain regions

Positive_regulation (increases) of Phosphorylation (phosphorylation) of MEK1/2 in brain associated with stress

1) Confidence 0.01 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC526203 Disease Relevance 0.70 Pain Relevance 0.26

Acute swim stress initiated a rapid increase in phosphorylation of the MAPKKs MEK1/2 and MKK4 in hippocampus, neocortex, prefrontal cortex, amygdala and striatum.

Positive_regulation (increase) of Phosphorylation (phosphorylation) of MEK1/2 in striatum associated with stress, hippocampus and amygdala

2) Confidence 0.01 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC526203 Disease Relevance 0.49 Pain Relevance 0.44

Acute swim stress initiated a rapid increase in phosphorylation of the MAPKKs MEK1/2 and MKK4 in hippocampus, neocortex, prefrontal cortex, amygdala and striatum.

Positive_regulation (increase) of in amygdala Phosphorylation (phosphorylation) of MEK1/2 in striatum associated with stress, hippocampus and amygdala

3) Confidence 0.00 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC526203 Disease Relevance 0.49 Pain Relevance 0.44

Acute swim stress initiated a rapid increase in phosphorylation of the MAPKKs MEK1/2 and MKK4 in hippocampus, neocortex, prefrontal cortex, amygdala and striatum.

Positive_regulation (increase) of in cortex Phosphorylation (phosphorylation) of MEK1/2 in striatum associated with stress, hippocampus and amygdala

4) Confidence 0.00 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC526203 Disease Relevance 0.49 Pain Relevance 0.44

General Comments

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