INT179420

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Context Info
Confidence 0.01
First Reported 2004
Last Reported 2004
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 2.17
Pain Relevance 1.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Map2k2) mitochondrion (Map2k2) Golgi apparatus (Map2k2)
nucleus (Map2k2)
Anatomy Link Frequency
striatum 4
brain 2
amygdala 1
cortex 1
Map2k2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Hippocampus 88 99.48 Very High Very High Very High
analgesia 4 97.92 Very High Very High Very High
amygdala 48 97.76 Very High Very High Very High
nMDA receptor 20 91.12 High High
Dopamine 4 69.08 Quite High
Glutamate receptor 4 46.24 Quite Low
Neurotransmitter 4 33.72 Quite Low
Visceral pain 8 24.92 Low Low
Inflammation 4 20.12 Low Low
depression 12 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 268 99.70 Very High Very High Very High
Anxiety Disorder 8 47.12 Quite Low
Depressive Disorder 4 46.16 Quite Low
Shock 8 26.24 Quite Low
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super / Visceral Pain

8 24.92 Low Low
Convulsion 4 22.84 Low Low
Apoptosis 4 20.68 Low Low
INFLAMMATION 4 20.12 Low Low
Depression 16 5.00 Very Low Very Low Very Low
Glioma 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Swim stress elicits large increases in phosphorylation of MEK1/2 in all brain regions
Positive_regulation (increases) of Phosphorylation (phosphorylation) of MEK1/2 in brain associated with stress
1) Confidence 0.01 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC526203 Disease Relevance 0.70 Pain Relevance 0.26
Acute swim stress initiated a rapid increase in phosphorylation of the MAPKKs MEK1/2 and MKK4 in hippocampus, neocortex, prefrontal cortex, amygdala and striatum.
Positive_regulation (increase) of Phosphorylation (phosphorylation) of MEK1/2 in striatum associated with stress, hippocampus and amygdala
2) Confidence 0.01 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC526203 Disease Relevance 0.49 Pain Relevance 0.44
Acute swim stress initiated a rapid increase in phosphorylation of the MAPKKs MEK1/2 and MKK4 in hippocampus, neocortex, prefrontal cortex, amygdala and striatum.
Positive_regulation (increase) of in amygdala Phosphorylation (phosphorylation) of MEK1/2 in striatum associated with stress, hippocampus and amygdala
3) Confidence 0.00 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC526203 Disease Relevance 0.49 Pain Relevance 0.44
Acute swim stress initiated a rapid increase in phosphorylation of the MAPKKs MEK1/2 and MKK4 in hippocampus, neocortex, prefrontal cortex, amygdala and striatum.
Positive_regulation (increase) of in cortex Phosphorylation (phosphorylation) of MEK1/2 in striatum associated with stress, hippocampus and amygdala
4) Confidence 0.00 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC526203 Disease Relevance 0.49 Pain Relevance 0.44

General Comments

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