INT179421

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Context Info
Confidence 0.58
First Reported 2004
Last Reported 2004
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 13
Disease Relevance 5.28
Pain Relevance 2.99

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Map2k4) nucleus (Map2k4)
Anatomy Link Frequency
brain 4
neocortex 1
striatum 1
amygdala 1
cortex 1
Map2k4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Hippocampus 286 99.84 Very High Very High Very High
amygdala 156 98.12 Very High Very High Very High
analgesia 13 97.44 Very High Very High Very High
nMDA receptor 65 90.64 High High
anesthesia 13 82.80 Quite High
halothane 13 82.04 Quite High
Catecholamine 13 81.20 Quite High
Dopamine 13 68.60 Quite High
Glutamate receptor 13 45.76 Quite Low
Visceral pain 26 35.80 Quite Low
Disease Link Frequency Relevance Heat
Stress 871 99.78 Very High Very High Very High
Sprains And Strains 13 76.48 Quite High
Glioma 26 71.64 Quite High
Anxiety Disorder 26 71.04 Quite High
Depressive Disorder 13 70.08 Quite High
Shock 26 37.12 Quite Low
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super / Visceral Pain

26 35.80 Quite Low
Convulsion 13 33.72 Quite Low
Cv Unclassified Under Development 13 31.84 Quite Low
Apoptosis 13 31.56 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The effect of varying the duration of swim on the phosphorylation of MEK1/2 and MKK4 was examined in neocortex and hippocampus.
Phosphorylation (phosphorylation) of MKK4 in hippocampus associated with hippocampus
1) Confidence 0.58 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC526203 Disease Relevance 0.37 Pain Relevance 0.28
Moreover, MKK7, like MKK4, phosphorylates JNK [40].
Phosphorylation (phosphorylates) of MKK7
2) Confidence 0.58 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC526203 Disease Relevance 0.41 Pain Relevance 0.03
Swim stress increases phosphorylation of MKK4 in all brain regions
Phosphorylation (phosphorylation) of MKK4 in brain associated with stress
3) Confidence 0.58 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC526203 Disease Relevance 0.22 Pain Relevance 0.25
Moreover, MKK7, like MKK4, phosphorylates JNK [40].
Phosphorylation (phosphorylates) of MKK4
4) Confidence 0.58 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC526203 Disease Relevance 0.41 Pain Relevance 0.03
The results presented establish unambiguously that forced swim stress elicits a rapid and profound but relatively transient increase in the phosphorylation (and consequently the presumed activation) of the MEK-Erk and MKK4-JNK signaling pathways in, at the least, the five brain regions examined.
Phosphorylation (phosphorylation) of MKK4 in brain associated with stress
5) Confidence 0.57 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC526203 Disease Relevance 0.40 Pain Relevance 0.10
Acute swim stress initiated a rapid increase in phosphorylation of the MAPKKs MEK1/2 and MKK4 in hippocampus, neocortex, prefrontal cortex, amygdala and striatum.
Phosphorylation (phosphorylation) of MKK4 in striatum associated with stress, hippocampus and amygdala
6) Confidence 0.44 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC526203 Disease Relevance 0.49 Pain Relevance 0.44
The present study followed up that investigation by examining the effects of a different common stressor, forced swim stress, extended the number of brain areas examined, and also evaluated changes in the phosphorylation state of the respective upstream MAPKK activators MEK1/2, MKK4 (also known as SEK1 and JNKK) and MKK3/6.
Phosphorylation (phosphorylation) of MKK4 in brain associated with stress
7) Confidence 0.44 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC526203 Disease Relevance 0.74 Pain Relevance 0.20
Moreover, the magnitude of the increase in phosphorylation of MEK1/2 and MKK4 was much greater than for their cognate substrates.
Phosphorylation (phosphorylation) of MKK4
8) Confidence 0.44 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC526203 Disease Relevance 0.59 Pain Relevance 0.34
Thus, one may posit that kinases (e.g., MEK1/2, MKK4) whose basal state of phosphorylation is very low may be subject to large increases, whereas those whose basal state is comparatively larger (e.g., Erk, JNK) demonstrate much smaller increases.
Phosphorylation (phosphorylation) of MKK4
9) Confidence 0.44 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC526203 Disease Relevance 0.06 Pain Relevance 0.09
Swim stress specifically and markedly enhanced the phosphorylation of the MAPKKs P-MEK1/2 and P-MKK4 in all brain regions tested without apparent alteration in the phosphorylation of P-MKK3/6.
Phosphorylation (phosphorylation) of MKK4 in brain associated with stress
10) Confidence 0.44 Published 2004 Journal BMC Neurosci Section Abstract Doc Link PMC526203 Disease Relevance 0.24 Pain Relevance 0.07
The effect of varying the duration of swim on the phosphorylation of MEK1/2 and MKK4 was examined in neocortex and hippocampus.
Phosphorylation (phosphorylation) of MKK4 in neocortex associated with hippocampus
11) Confidence 0.20 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC526203 Disease Relevance 0.37 Pain Relevance 0.28
Acute swim stress initiated a rapid increase in phosphorylation of the MAPKKs MEK1/2 and MKK4 in hippocampus, neocortex, prefrontal cortex, amygdala and striatum.
Phosphorylation (phosphorylation) of MKK4 in cortex associated with stress, hippocampus and amygdala
12) Confidence 0.15 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC526203 Disease Relevance 0.49 Pain Relevance 0.44
Acute swim stress initiated a rapid increase in phosphorylation of the MAPKKs MEK1/2 and MKK4 in hippocampus, neocortex, prefrontal cortex, amygdala and striatum.
Phosphorylation (phosphorylation) of MKK4 in amygdala associated with stress, hippocampus and amygdala
13) Confidence 0.15 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC526203 Disease Relevance 0.49 Pain Relevance 0.44

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