INT179422

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Context Info
Confidence 0.03
First Reported 2004
Last Reported 2004
Negated 2
Speculated 0
Reported most in Body
Documents 1
Total Number 8
Disease Relevance 3.50
Pain Relevance 1.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
brain 3
neocortex 1
hippocampus 1
Smek1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Hippocampus 176 99.00 Very High Very High Very High
amygdala 96 98.08 Very High Very High Very High
anesthesia 8 75.12 Quite High
halothane 8 74.36 Quite High
Catecholamine 8 61.00 Quite High
Visceral pain 16 51.48 Quite High
ischemia 8 50.88 Quite High
nMDA receptor 40 5.00 Very Low Very Low Very Low
depression 24 5.00 Very Low Very Low Very Low
Central nervous system 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 536 99.98 Very High Very High Very High
Glioma 16 92.68 High High
Sprains And Strains 8 68.80 Quite High
Shock 16 52.60 Quite High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super / Visceral Pain

16 51.48 Quite High
Cv Unclassified Under Development 8 50.88 Quite High
Depression 32 5.00 Very Low Very Low Very Low
Anxiety Disorder 16 5.00 Very Low Very Low Very Low
Depressive Disorder 8 5.00 Very Low Very Low Very Low
Apoptosis 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Nevertheless, differences in phosphorylation stoichiometry cannot explain why, in some brain regions (i.e., hippocampus and amygdala, Figs. 1 and 2), there were no discernable increases in P-Erk after swim stress, despite large increases in P-MEK1/2.
Positive_regulation (increases) of P-MEK1 in brain associated with stress, hippocampus and amygdala
1) Confidence 0.03 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC526203 Disease Relevance 0.19 Pain Relevance 0.13
The effect on both kinases gradually reached a maximum at 15 min (longer times were not assessed), except for the increase in P-MEK1/2 in neocortex, which peaked at 5 min (Fig. 8).
Neg (except) Positive_regulation (increase) of P-MEK1 in neocortex
2) Confidence 0.03 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC526203 Disease Relevance 0.46 Pain Relevance 0.26
As shown above, the major impact of swim stress was to activate the corresponding upstream MAPKKs of Erk and JNK, i.e., to increase P-MEK1/2 and P-MKK4, respectively.
Positive_regulation (increase) of P-MEK1 associated with stress
3) Confidence 0.02 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC526203 Disease Relevance 0.57 Pain Relevance 0.12
However, Liu et al. [38] did not determine the effects of swim stress on P-MEK1/2 levels (which we found were also markedly elevated: Figs. 1 and 2).
Positive_regulation (elevated) of P-MEK1 associated with stress
4) Confidence 0.02 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC526203 Disease Relevance 0.35 Pain Relevance 0.12
Swim stress significantly increased P-MEK1/2 levels from 4.5-fold (hippocampus) to more than 100-fold (striatum) in the various brain areas (Fig. 2).
Positive_regulation (increased) of P-MEK1 in hippocampus associated with stress and hippocampus
5) Confidence 0.02 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC526203 Disease Relevance 0.50 Pain Relevance 0.29
It seems likely, therefore, that basal levels of brain P-MKK3/6 are very low (cf. basal levels of P-MKK4, Fig. 3), and, unlike P-MEK1/2 and P-MKK4, are not induced by swim stress.
Neg (not) Positive_regulation (induced) of P-MEK1 in brain associated with stress
6) Confidence 0.02 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC526203 Disease Relevance 0.63 Pain Relevance 0.08
Surprisingly, levels of the phosphorylated MAPKKs, P-MEK1/2 and P-MKK4 (activators of the Erk and JNK pathways, respectively) were increased in all five brain regions, and much more dramatically (P-MEK1/2, 4.5 to > 100-fold; P-MKK4, 12 to ~300-fold).
Positive_regulation (increased) of P-MEK1 in brain
7) Confidence 0.02 Published 2004 Journal BMC Neurosci Section Abstract Doc Link PMC526203 Disease Relevance 0.51 Pain Relevance 0.24
It is obvious from Figs. 2 and 4 that whereas swim stress elevated P-MEK1/2 and P-MKK4 levels dramatically, the effects on their substrates, P-Erk2 and P-JNK, respectively, were much more modest.
Positive_regulation (elevated) of P-MEK1 associated with stress
8) Confidence 0.02 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC526203 Disease Relevance 0.25 Pain Relevance 0.07

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