INT179444

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Context Info
Confidence 0.03
First Reported 2004
Last Reported 2004
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0
Pain Relevance 1.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Gpr156) cytoskeleton organization (Hmmr) signal transducer activity (Gpr156)
cell-cell signaling (Hmmr) cytoplasm (Hmmr)
Anatomy Link Frequency
ventral 1
Hmmr (Rattus norvegicus)
Gpr156 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 146 99.20 Very High Very High Very High
antagonist 8 98.32 Very High Very High Very High
Nicotine 86 95.72 Very High Very High Very High
Ventral tegmentum 138 95.12 Very High Very High Very High
agonist 8 93.56 High High
Nucleus accumbens 18 75.28 Quite High
gABA 8 74.52 Quite High
midbrain 10 68.24 Quite High
nMDA receptor 4 62.20 Quite High
GABAergic 6 60.72 Quite High
Disease Link Frequency Relevance Heat
Decapitation 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The GABAB receptor-mediated inhibition of the activity of the mesocorticolimbic neurones might explain the effectiveness of baclofen to suppress nicotine self-administration when microinjected into the VTA [34].
receptor-mediated Negative_regulation (inhibition) of GABAB associated with ventral tegmentum and nicotine
1) Confidence 0.03 Published 2004 Journal BMC Pharmacol Section Body Doc Link PMC526276 Disease Relevance 0 Pain Relevance 1.04
The existence of a tonic GABAB receptor-mediated inhibition of somatodendritic DA release has been suggested by the evidence that, in vivo, the administration of CGP55845A into the ventral tegmental area produces a dose-dependent increase in VTA dopamine levels [49].
receptor-mediated Negative_regulation (inhibition) of GABAB in ventral associated with ventral tegmentum and dopamine
2) Confidence 0.02 Published 2004 Journal BMC Pharmacol Section Body Doc Link PMC526276 Disease Relevance 0 Pain Relevance 0.75

General Comments

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