INT179449

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Context Info
Confidence 0.07
First Reported 2004
Last Reported 2009
Negated 1
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 0.30
Pain Relevance 0.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (PDE1B) signal transduction (PDE1B) nucleolus (PDE1B)
nucleus (PDE1B) cytoplasm (PDE1B)
PDE1B (Homo sapiens)
Pain Link Frequency Relevance Heat
qutenza 40 81.36 Quite High
antidepressant 17 54.16 Quite High
depression 8 50.00 Quite Low
Migraine 8 5.00 Very Low Very Low Very Low
substance P 8 5.00 Very Low Very Low Very Low
fluoxetine 5 5.00 Very Low Very Low Very Low
Desipramine 5 5.00 Very Low Very Low Very Low
tetrodotoxin 4 5.00 Very Low Very Low Very Low
Neurotransmitter 4 5.00 Very Low Very Low Very Low
Sumatriptan 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 28 85.76 High High
Depression 44 53.40 Quite High
Apoptosis 4 7.60 Low Low
Heart Disease 4 7.16 Low Low
Diabetes Mellitus 4 6.56 Low Low
Cancer 10 6.16 Low Low
Migraine Disorders 24 5.00 Very Low Very Low Very Low
Syndrome 12 5.00 Very Low Very Low Very Low
Vomiting 8 5.00 Very Low Very Low Very Low
Cognitive Disorder 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Because of their unique ligand-binding topologies, the GAF domains of PDEs are likely to offer good new targets for rational drug design.9 PDE11A exhibits properties of dual-substrate PDE and hydrolyzes both cAMP and cGMP into AMP and GMP respectively with similar Km values.4–6 The Km for cAMP and cGMP were similar for all the four PDE11A variants.4–6
PDEs Binding (binding) of
1) Confidence 0.07 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2695232 Disease Relevance 0.05 Pain Relevance 0.03
These entities that do not have known or documented associations, yet share intermediate relationships, have been referred to as "transitive", "implicit", "indirect" or "inferable" relationships.
known Neg (not) Binding (associations) of
2) Confidence 0.04 Published 2004 Journal BMC Bioinformatics Section Body Doc Link PMC526381 Disease Relevance 0.16 Pain Relevance 0
Since directly associated objects also share associations with other objects, it is reasoned that the strength of known associations can be used to benchmark how well the scores from implicit associations correlate with the relative importance of an association.
known Binding (associations) of
3) Confidence 0.03 Published 2004 Journal BMC Bioinformatics Section Body Doc Link PMC526381 Disease Relevance 0 Pain Relevance 0
Thus, the higher that known, relevant associations are ranked within the set of all inferable associations, the better the ranking method is.
known Binding (associations) of
4) Confidence 0.03 Published 2004 Journal BMC Bioinformatics Section Body Doc Link PMC526381 Disease Relevance 0 Pain Relevance 0.08
Of the models tested, the shared minimum MIM (MMIM) model is found to correlate best with the observed strength and frequency of known associations.
known Binding (associations) of
5) Confidence 0.03 Published 2004 Journal BMC Bioinformatics Section Abstract Doc Link PMC526381 Disease Relevance 0.08 Pain Relevance 0

General Comments

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