INT179450

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Context Info
Confidence 0.50
First Reported 2004
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 1.04
Pain Relevance 0.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (NCF1) cytosol (NCF1) GTPase activity (NCF1)
cytoplasm (NCF1)
NCF1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Multiple sclerosis 32 79.12 Quite High
agonist 12 74.04 Quite High
Arthritis 5 37.16 Quite Low
Inflammatory mediators 3 36.44 Quite Low
Neuritis 1 27.56 Quite Low
Inflammation 25 5.00 Very Low Very Low Very Low
addiction 9 5.00 Very Low Very Low Very Low
TRP channel 6 5.00 Very Low Very Low Very Low
antagonist 6 5.00 Very Low Very Low Very Low
Inflammatory response 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Chronic Disease 9 100.00 Very High Very High Very High
Autoimmune Disease 13 98.64 Very High Very High Very High
Falciparum Malaria 5 96.08 Very High Very High Very High
Targeted Disruption 23 89.12 High High
Malaria 24 88.48 High High
Demyelinating Disease 34 79.12 Quite High
Neutrophil Disorders 11 73.56 Quite High
Disease 50 62.12 Quite High
Parasitic Infection 3 50.00 Quite Low
Arthritis 5 37.16 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This study evaluates whether NCF1 ?
Spec (whether) Positive_regulation (evaluates) of NCF1
1) Confidence 0.50 Published 2008 Journal Malar J Section Body Doc Link PMC2635379 Disease Relevance 0.64 Pain Relevance 0.10
The term "chronic disease" was used to increase the sensitivity of the search.
Positive_regulation (increase) of chronic associated with chronic disease
2) Confidence 0.36 Published 2004 Journal Health Qual Life Outcomes Section Body Doc Link PMC526383 Disease Relevance 0.16 Pain Relevance 0
As Fig. 6b demonstrates, massive reduction in Hv1 level does not prevent high-level expression of the phox subunits Nox2, p22phox and p47phox.


Positive_regulation (subunits) of p47phox
3) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2990768 Disease Relevance 0.16 Pain Relevance 0
For example, [Ca2+]c elevation and phosphorylation of p47phox by different protein kinases (PKC, MAPK, PKA, p21-activated kinase) allowing conformational changes of p47phox may promote oxidase activation in response to GM-CSF [25].
Positive_regulation (elevation) of p47phox
4) Confidence 0.15 Published 2008 Journal J Leukoc Biol Section Body Doc Link PMC2567897 Disease Relevance 0 Pain Relevance 0
For example, [Ca2+]c elevation and phosphorylation of p47phox by different protein kinases (PKC, MAPK, PKA, p21-activated kinase) allowing conformational changes of p47phox may promote oxidase activation in response to GM-CSF [25].
Positive_regulation (changes) of p47phox
5) Confidence 0.15 Published 2008 Journal J Leukoc Biol Section Body Doc Link PMC2567897 Disease Relevance 0 Pain Relevance 0
antisense inhibits phosphorylation and translocation of p47phox induced by fMLF, providing evidence for the involvement of PKC?
Positive_regulation (induced) of p47phox
6) Confidence 0.14 Published 2008 Journal J Leukoc Biol Section Body Doc Link PMC2567897 Disease Relevance 0.08 Pain Relevance 0.07

General Comments

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