INT179456

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Context Info
Confidence 0.39
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 5.95
Pain Relevance 3.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Mmp3) extracellular space (Mmp3) extracellular region (Mmp3)
proteinaceous extracellular matrix (Mmp3) nucleus (Mmp3) protein complex (Mmp3)
Anatomy Link Frequency
plasma 1
hepatocytes 1
Mmp3 (Mus musculus)
Pain Link Frequency Relevance Heat
metalloproteinase 206 100.00 Very High Very High Very High
COX-2 inhibitor 8 98.24 Very High Very High Very High
Arthritis 277 94.48 High High
rheumatoid arthritis 303 93.68 High High
cva 7 91.04 High High
Inflammation 256 77.44 Quite High
imagery 60 75.12 Quite High
chemokine 8 74.08 Quite High
cytokine 76 73.68 Quite High
fibrosis 76 57.32 Quite High
Disease Link Frequency Relevance Heat
Disease 101 99.42 Very High Very High Very High
Apoptosis 96 98.84 Very High Very High Very High
Necrosis 33 98.28 Very High Very High Very High
Hepatitis 8 95.48 Very High Very High Very High
Coronary Aneurysm 16 94.84 High High
Arthritis 289 94.48 High High
Rheumatoid Arthritis 303 93.68 High High
Abdominal Aortic Aneurysm 3 91.04 High High
Neutropenia 4 88.16 High High
Acute Liver Failure 2 87.76 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In this study, mice treated with BB-94 as well as mice deficient in Mmp2, Mmp3 or Mmp9 had lower levels of apoptosis and necrosis of hepatocytes, and better survival.
Negative_regulation (deficient) of Mmp3 in hepatocytes associated with necrosis and apoptosis
1) Confidence 0.39 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2892485 Disease Relevance 0.83 Pain Relevance 0.09
Marimastat efficiently inhibits MMP-2, MMP-3, MMP-7, MMP-9, MMP-13 and TACE activity, with IC50s in the nM range [26], [54].
Negative_regulation (inhibits) of MMP-3
2) Confidence 0.39 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2892485 Disease Relevance 0.05 Pain Relevance 0.03
Luan et al. [44] reported that a number of statins inhibit MMP-3 activity in rabbits.
Negative_regulation (inhibit) of MMP-3
3) Confidence 0.30 Published 2004 Journal Curr Control Trials Cardiovasc Med Section Body Doc Link PMC526392 Disease Relevance 0.93 Pain Relevance 0.41
In contrast, disease-related increases in plasma MMP-3 were decreased ~50% by all treatments with minimal statistical significance.
Negative_regulation (decreased) of MMP-3 in plasma associated with disease
4) Confidence 0.18 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911895 Disease Relevance 0.85 Pain Relevance 0.42
In addition to improving clinical outcomes measurements as determined by the American College of Rheumatology (ACR) criteria as early as 1 week after oral administration, R406 also reduced the level of serum IL-6 and MMP-3 (stromelysin-1) in the groups receiving 100?
Negative_regulation (level) of MMP-3
5) Confidence 0.13 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2842969 Disease Relevance 0.85 Pain Relevance 0.37
In addition to improving clinical outcomes measurements as determined by the American College of Rheumatology (ACR) criteria as early as 1 week after oral administration, R406 also reduced the level of serum IL-6 and MMP-3 (stromelysin-1) in the groups receiving 100?
Negative_regulation (level) of stromelysin-1
6) Confidence 0.13 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2842969 Disease Relevance 0.85 Pain Relevance 0.37
resulted in a significant reduction in detectable MMP-1 and MMP-3 levels when compared to that elicited by the IL-1?
Negative_regulation (reduction) of MMP-3 associated with metalloproteinase
7) Confidence 0.11 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888198 Disease Relevance 0.52 Pain Relevance 0.90
resulted in a significant reduction in detectable MMP-3 levels when compared to that elicited by IL-1?
Negative_regulation (reduction) of MMP-3 associated with metalloproteinase
8) Confidence 0.09 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888198 Disease Relevance 1.07 Pain Relevance 0.67

General Comments

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