INT179458

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Context Info
Confidence 0.59
First Reported 2004
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 3.68
Pain Relevance 1.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Mmp3) extracellular space (Mmp3) extracellular region (Mmp3)
proteinaceous extracellular matrix (Mmp3) nucleus (Mmp3) protein complex (Mmp3)
Anatomy Link Frequency
cartilage 1
extracellular matrix 1
Mmp3 (Mus musculus)
Pain Link Frequency Relevance Heat
metalloproteinase 81 100.00 Very High Very High Very High
Inflammation 51 95.24 Very High Very High Very High
Arthritis 55 91.68 High High
Inflammatory mediators 2 76.96 Quite High
rheumatoid arthritis 18 76.00 Quite High
cva 7 69.44 Quite High
chemokine 4 56.56 Quite High
cytokine 9 37.68 Quite Low
imagery 10 27.52 Quite Low
corticosteroid 1 5.40 Low Low
Disease Link Frequency Relevance Heat
Cancer 41 96.36 Very High Very High Very High
INFLAMMATION 53 95.24 Very High Very High Very High
Disease 37 92.36 High High
Metastasis 9 91.68 High High
Experimental Arthritis 4 91.68 High High
Atherosclerotic Plaque 2 90.04 High High
Coronary Aneurysm 16 87.16 High High
Breast Cancer 6 85.92 High High
Arthritis 56 85.68 High High
Aneurism 21 83.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Schoenhagen et al. [40] suggest that the degradation of extracellular matrix by MMP-3 may contribute to the expansion of the coronary vessel wall.
Protein_catabolism (degradation) of MMP-3 in extracellular matrix
1) Confidence 0.59 Published 2004 Journal Curr Control Trials Cardiovasc Med Section Body Doc Link PMC526392 Disease Relevance 0.87 Pain Relevance 0.14
Rather unexpected was the finding that, in combination with MMP-3 and anti-collagen IgG2a, detection of cartilage or bone degradation products such as COMP and CTXI in serum could not improve the predictive value of the regression models for cartilage or bone destruction as assessed by knee histology.
Protein_catabolism (degradation) of MMP-3 in cartilage associated with metalloproteinase
2) Confidence 0.52 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945063 Disease Relevance 1.16 Pain Relevance 0.72
Data suggest that GPI-anchored MMPs do not act as progelatinase activators, are mostly non-ECM degrading enzymes, and do not promote cell migration and invasion.
Protein_catabolism (degrading) of progelatinase associated with metalloproteinase
3) Confidence 0.08 Published 2011 Journal Biochemistry Research International Section Body Doc Link PMC2989751 Disease Relevance 1.65 Pain Relevance 0.21

General Comments

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