INT179489

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Context Info
Confidence 0.60
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 5
Disease Relevance 3.62
Pain Relevance 3.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Fabp4) lipid particle (Fabp4) nucleus (Fabp4)
cytoplasm (Fabp4)
Anatomy Link Frequency
fat 2
Fabp4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
backache 387 100.00 Very High Very High Very High
agonist 48 98.04 Very High Very High Very High
Pain 90 96.34 Very High Very High Very High
tolerance 4 5.00 Very Low Very Low Very Low
lumbar region 3 5.00 Very Low Very Low Very Low
metalloproteinase 3 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
dexamethasone 1 5.00 Very Low Very Low Very Low
alcohol 1 5.00 Very Low Very Low Very Low
isoflurane 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Low Back Pain 399 100.00 Very High Very High Very High
Pain 78 96.34 Very High Very High Very High
Obesity 56 91.04 High High
Body Weight 10 64.68 Quite High
Sprains And Strains 3 59.80 Quite High
Peripheral Arterial Disease 3 56.72 Quite High
Hypertension 2 54.64 Quite High
Hyperlipidemia 2 53.92 Quite High
Cancer 3 53.28 Quite High
Insulin Resistance 14 47.32 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This increased awareness of the prevalence of ALBP is reflected in the increase in published research on ALBP over the past 30 years.
Positive_regulation (increase) of ALBP associated with backache
1) Confidence 0.60 Published 2010 Journal Journal of pain research Section Body Doc Link PMC3004638 Disease Relevance 1.03 Pain Relevance 1.03
The ability to identify causes of ALBP is dependent on the ability to accurately define and classify ALBP.
Positive_regulation (causes) of ALBP associated with backache
2) Confidence 0.50 Published 2010 Journal Journal of pain research Section Body Doc Link PMC3004638 Disease Relevance 1.09 Pain Relevance 1.03
This constrains the ability to synthesize the literature to identify risk factors, as studies with different pain definitions (in terms of severity, chronicity, and intensity) lack homogeneity, as they are describing different pain situations.16 Within each of the three broad classifications used in this review, there were significant differences in the period prevalence rates across studies, suggesting a wide variation in ALBP prevalence rates.
Positive_regulation (variation) of ALBP associated with pain and backache
3) Confidence 0.43 Published 2010 Journal Journal of pain research Section Body Doc Link PMC3004638 Disease Relevance 0.85 Pain Relevance 0.85
AP2 was abundant in epididymal fat tissues, and was only slightly increased by GI262570 in a non-dose-dependent manner (data not shown).
Positive_regulation (increased) of AP2 in fat
4) Confidence 0.32 Published 2004 Journal BMC Pharmacol Section Body Doc Link PMC526775 Disease Relevance 0.11 Pain Relevance 0.23
Furthermore, KCL significantly inhibited pancreatic lipase activity in vitro, and also significantly inhibited fat accumulation and mRNA expression of fatty acid binding protein 2 (aP2) and peroxisome proliferator-activated ?
Positive_regulation (accumulation) of aP2 in fat
5) Confidence 0.32 Published 2010 Journal Lipids Health Dis Section Abstract Doc Link PMC3002919 Disease Relevance 0.53 Pain Relevance 0

General Comments

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