INT179497

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Context Info
Confidence 0.50
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 12
Total Number 12
Disease Relevance 6.49
Pain Relevance 1.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Tlr4) plasma membrane (Tlr4) intracellular (Tlr4)
cytoplasm (Tlr4)
Anatomy Link Frequency
cavity 4
macrophages 2
neurons 2
bone marrow 2
Tlr4 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammatory response 40 98.20 Very High Very High Very High
ketamine 10 97.76 Very High Very High Very High
cytokine 101 94.32 High High
Catecholamine 46 90.92 High High
anesthesia 6 90.64 High High
Inflammation 213 90.08 High High
agonist 8 86.76 High High
cva 3 80.00 Quite High
Intracerebroventricular 29 78.64 Quite High
chemokine 9 71.08 Quite High
Disease Link Frequency Relevance Heat
Fever 61 99.86 Very High Very High Very High
Injury 160 99.78 Very High Very High Very High
Infection 27 99.36 Very High Very High Very High
Peritonitis 48 99.12 Very High Very High Very High
Bacterial Infection 3 98.24 Very High Very High Very High
INFLAMMATION 256 97.80 Very High Very High Very High
Burns 222 96.80 Very High Very High Very High
Body Weight 7 96.16 Very High Very High Very High
Gastritis 6 91.32 High High
Cv General 2 Under Development 6 86.32 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
At 8 hr after thermal injury, lung was harvested for TLR4 mRNA assay, intestinal mucosa was harvested for TLR4 mRNA assay, and peritoneal cells were harvested from the abdominal cavity for bacterial killing activity and TLR4 as well as TNF?
Positive_regulation (harvested) of TLR4 mRNA Binding (assay) of in cavity associated with injury
1) Confidence 0.50 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2901327 Disease Relevance 1.37 Pain Relevance 0.04
At 8 hr after thermal injury, lung was harvested for TLR4 mRNA assay, intestinal mucosa was harvested for TLR4 mRNA assay, and peritoneal cells were harvested from the abdominal cavity for bacterial killing activity and TLR4 as well as TNF?
Positive_regulation (harvested) of TLR4 mRNA Binding (assay) of in cavity associated with injury
2) Confidence 0.50 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2901327 Disease Relevance 1.35 Pain Relevance 0.04
Thus, the exact nature of the interaction between TLR-4, fatty acids and endotoxin requires further investigation.
Positive_regulation (requires) of TLR-4 Binding (interaction) of
3) Confidence 0.48 Published 2010 Journal BMC Physiol Section Body Doc Link PMC2984476 Disease Relevance 0.68 Pain Relevance 0.20
TLR4-mediated recognition of LPS is required for efficient recognition of Gram-negative bacterial infections and some studies shows important roles that TLR4 plays with respect to LPS binding and signaling even in H. pylori infection [16].
Positive_regulation (required) of LPS Binding (recognition) of associated with bacterial infection and infection
4) Confidence 0.43 Published 2007 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2291505 Disease Relevance 0.92 Pain Relevance 0
Thus, these data strongly imply that LPS-activated microglial-mediated paracrine oxidative damage to neurons in vivo is dependent on CD14, MyD88, p50 of NF-?
Positive_regulation (activated) of LPS Binding (microglial) of in neurons
5) Confidence 0.35 Published 2004 Journal J Neuroinflammation Section Body Doc Link PMC527876 Disease Relevance 0.07 Pain Relevance 0.14
Cells were stimulated with addition of LPS (1 µg/ml, Salmonella typhosa 0901, Difco, Detroit, MI), and the medium was harvested and stored at ?
Positive_regulation (stimulated) of LPS Binding (addition) of
6) Confidence 0.30 Published 2007 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2243250 Disease Relevance 0 Pain Relevance 0.06
Subsequent transfer from CD14 to an additional accessory molecule MD-2 then allows TLR4-mediated LPS recognition [57].
Positive_regulation (mediated) of LPS Binding (recognition) of
7) Confidence 0.26 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2913853 Disease Relevance 0.07 Pain Relevance 0.04
In particular, LPS bind to their CD14 receptor on the surface of macrophages, resulting in the transcriptional induction of iNOS with subsequent release of NO [35].
Positive_regulation (resulting) of LPS Binding (bind) of in macrophages
8) Confidence 0.18 Published 2010 Journal Nephrology Dialysis Transplantation Section Body Doc Link PMC2796899 Disease Relevance 0.77 Pain Relevance 0.26
We determined the effect of PZ on expression of iNOS mRNA 6 h after LPS injection (Fig. 6).
Positive_regulation (after) of LPS Binding (injection) of
9) Confidence 0.12 Published 2010 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2872229 Disease Relevance 0.24 Pain Relevance 0.08
Six hours following stimulation with LPS, cultures were stimulated with Bz-ATP and 30 min later IL-1?
Positive_regulation (stimulated) of LPS Binding (following) of
10) Confidence 0.12 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2096758 Disease Relevance 0.20 Pain Relevance 0.18
IgG immune complex and LPS-induced alveolitis
Positive_regulation (induced) of LPS Binding (complex) of
11) Confidence 0.03 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2636885 Disease Relevance 0.32 Pain Relevance 0.21
The key role of macrophages in the initiation of fever agrees with our recent finding that the first febrile phase depends entirely on the recognition of LPS (via the Toll-like receptor-4) by bone marrow-derived cells [50].
Positive_regulation (depends) of LPS Binding (recognition) of in bone marrow associated with fever
12) Confidence 0.01 Published 2006 Journal PLoS Biology Section Body Doc Link PMC1551923 Disease Relevance 0.48 Pain Relevance 0.03

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