INT179507

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Context Info
Confidence 0.17
First Reported 2004
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.07
Pain Relevance 0.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Tlr4, Tlr2) plasma membrane (Tlr4, Tlr2) intracellular (Tlr4, Tlr2)
cytoplasm (Tlr4, Tlr2)
Anatomy Link Frequency
plasma 1
Tlr4 (Mus musculus)
Tlr2 (Mus musculus)
Pain Link Frequency Relevance Heat
Pyramidal cell 7 94.80 High High
Intracerebroventricular 29 89.20 High High
Inflammation 20 87.20 High High
Paracetamol 1 58.24 Quite High
cINOD 10 43.52 Quite Low
Inflammatory response 7 5.00 Very Low Very Low Very Low
cytokine 5 5.00 Very Low Very Low Very Low
ischemia 5 5.00 Very Low Very Low Very Low
chemokine 3 5.00 Very Low Very Low Very Low
COX2 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hemorrhagic Shock 32 99.84 Very High Very High Very High
Targeted Disruption 1 99.08 Very High Very High Very High
Adult Respiratory Distress Syndrome 27 95.08 Very High Very High Very High
INFLAMMATION 24 87.20 High High
Injury 19 82.08 Quite High
Toxicity 1 58.60 Quite High
Alzheimer's Dementia 17 53.12 Quite High
Stress 10 46.60 Quite Low
Shock 7 5.00 Very Low Very Low Very Low
Systemic Inflammatory Response Syndrome 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Recent studies have further demonstrated that ROS are important determinants for augmented TLR4-induced TLR2 upregulation in HS.
TLR4 Spec (determinants) Positive_regulation (upregulation) of TLR2 associated with hemorrhagic shock
1) Confidence 0.17 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2913855 Disease Relevance 0.92 Pain Relevance 0.10
TLR-2, like TLR-4, is one of the plasma membrane TLRs that may be activated by LPS and that also uses CD14 as a co-receptor.
LPS Positive_regulation (activated) of TLR-2 in plasma
2) Confidence 0.13 Published 2004 Journal J Neuroinflammation Section Body Doc Link PMC527876 Disease Relevance 0.15 Pain Relevance 0.38

General Comments

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