INT179530

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Context Info
Confidence 0.69
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 2.59
Pain Relevance 0.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (C3) extracellular space (C3) extracellular region (C3)
Anatomy Link Frequency
cardiomyocytes 1
cerebral cortex 1
synovium 1
C3 (Mus musculus)
Pain Link Frequency Relevance Heat
cerebral cortex 5 99.68 Very High Very High Very High
ischemia 15 94.40 High High
Arthritis 37 93.60 High High
tolerance 62 92.64 High High
Hippocampus 23 89.88 High High
rheumatoid arthritis 21 79.48 Quite High
Inflammation 43 72.76 Quite High
Inflammatory response 4 44.36 Quite Low
Pyramidal cell 1 30.64 Quite Low
cytokine 11 12.48 Low Low
Disease Link Frequency Relevance Heat
Myocardial Infarction 49 99.60 Very High Very High Very High
Cv Unclassified Under Development 14 94.40 High High
Arthritis 40 93.60 High High
Apoptosis 4 87.84 High High
Amyloid Plaque 27 86.80 High High
Disease 110 85.96 High High
Osteoarthritis 2 83.24 Quite High
Alzheimer's Dementia 5 81.00 Quite High
Rheumatoid Arthritis 21 79.48 Quite High
Targeted Disruption 10 79.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Importantly, we also detected mRNA for C3 in mouse synovium by both complementary DNA microarray and quantitative polymerase chain reaction (data not shown), although we did not observe an increase as arthritis unfolded.
Transcription (detected) of C3 in synovium associated with arthritis
1) Confidence 0.69 Published 2007 Journal Arthritis and Rheumatism Section Body Doc Link PMC2559465 Disease Relevance 0.63 Pain Relevance 0.28
, C1q and C3 transcripts.
Transcription (transcripts) of C3
2) Confidence 0.55 Published 2010 Journal European Journal of Immunology Section Body Doc Link PMC2988415 Disease Relevance 0.08 Pain Relevance 0.05
wk after grafting and the mRNA expression of C1q, C3 and IFN-?
Transcription (expression) of C3
3) Confidence 0.42 Published 2010 Journal European Journal of Immunology Section Body Doc Link PMC2988415 Disease Relevance 0 Pain Relevance 0.05
In a rat model of MI, C1-INH suppressed C3 mRNA expression and protein synthesis, while in cultured rat cardiomyocytes, C1-INH blocked deposition of C3 (Fu et al 2006b).
Transcription (expression) of C3 in cardiomyocytes associated with myocardial infarction
4) Confidence 0.21 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727911 Disease Relevance 1.11 Pain Relevance 0.18
A subsequent study by the same investigators [88] found that the mRNA level of C3 in the cerebral cortex was 5-fold higher in APP/TGF-?
Transcription (level) of C3 in cerebral cortex associated with cerebral cortex
5) Confidence 0.19 Published 2004 Journal J Neuroinflammation Section Body Doc Link PMC529311 Disease Relevance 0.77 Pain Relevance 0.14

General Comments

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