INT179532

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Context Info
Confidence 0.26
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 1.61
Pain Relevance 0.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (C3) extracellular space (C3) extracellular region (C3)
Anatomy Link Frequency
cleavage 3
plasma 1
C3 (Mus musculus)
Pain Link Frequency Relevance Heat
cerebral cortex 5 87.92 High High
Inflammatory response 10 87.60 High High
Hippocampus 26 76.44 Quite High
cytokine 66 65.52 Quite High
cva 17 58.00 Quite High
Pyramidal cell 1 57.76 Quite High
chemokine 7 56.52 Quite High
Inflammation 41 35.04 Quite Low
imagery 27 5.00 Very Low Very Low Very Low
ischemia 25 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Amyloid Plaque 27 97.64 Very High Very High Very High
INFLAMMATION 53 87.20 High High
Infection 94 85.56 High High
Cold Sores 367 85.16 High High
Apoptosis 42 82.16 Quite High
Dengue 64 74.40 Quite High
Disease 162 72.52 Quite High
Alzheimer's Dementia 8 67.56 Quite High
Targeted Disruption 11 65.68 Quite High
Hemorrhage 3 58.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the alternative pathway, C3 is spontaneously cleaved to C3a and C3b.
Protein_catabolism (cleaved) of C3
1) Confidence 0.26 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727911 Disease Relevance 0 Pain Relevance 0
CVF binds to mammalian FB in plasma and after cleavage of FB by FD, a stable, soluble C3 convertase is produced, the CVF-Bb complex (Cooper 1973).
Protein_catabolism (cleavage) of C3 in cleavage
2) Confidence 0.26 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727911 Disease Relevance 0 Pain Relevance 0
In this pathway the thioester bonds in C3 undergo hydrolysis which allows the binding of Factor B and its subsequent cleavage by plasma protease Factor D.
Protein_catabolism (cleavage) of C3 in plasma
3) Confidence 0.20 Published 2009 Journal Virol J Section Body Doc Link PMC2789730 Disease Relevance 0.37 Pain Relevance 0.03
Because C3b, an activation protein produced by cleavage of C3, functions as an opsonin [89], the increased C3 levels together with the reduced A?
Protein_catabolism (cleavage) of C3 in cleavage
4) Confidence 0.19 Published 2004 Journal J Neuroinflammation Section Body Doc Link PMC529311 Disease Relevance 0.51 Pain Relevance 0.18
All the complement cascades culminate in the central cleavage of C3 and in the generation of its active fragments C3a and C3b.
Protein_catabolism (cleavage) of C3 in cleavage
5) Confidence 0.18 Published 2010 Journal The Open Virology Journal Section Body Doc Link PMC2936037 Disease Relevance 0.73 Pain Relevance 0.13

General Comments

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