INT179539

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Context Info
Confidence 0.70
First Reported 2004
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 5.98
Pain Relevance 1.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (C3) extracellular space (C3) extracellular region (C3)
Anatomy Link Frequency
cleavage 4
leukocytes 2
brain 2
plaque 2
C3 (Mus musculus)
Pain Link Frequency Relevance Heat
Arthritis 111 99.00 Very High Very High Very High
imagery 3 94.44 High High
cerebral cortex 25 92.36 High High
ischemia 16 91.84 High High
rheumatoid arthritis 61 83.84 Quite High
Inflammation 102 82.40 Quite High
Hippocampus 72 80.88 Quite High
cva 8 79.20 Quite High
tolerance 31 68.56 Quite High
Pyramidal cell 3 62.16 Quite High
Disease Link Frequency Relevance Heat
Graft Vs Host Disease 10 99.80 Very High Very High Very High
Amyloid Plaque 88 99.60 Very High Very High Very High
Arthritis 120 99.00 Very High Very High Very High
Myocardial Infarction 49 98.08 Very High Very High Very High
Infarction 2 97.52 Very High Very High Very High
Disease 410 96.48 Very High Very High Very High
Reperfusion Injury 6 92.60 High High
Cv Unclassified Under Development 15 91.84 High High
Atherosclerotic Plaque 4 87.68 High High
Osteoarthritis 6 87.60 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In short, production of C3 by leukocytes was not required for K/BxN serum–induced arthritis, even with prolonged administration of arthritogenic serum.
Neg (not) Positive_regulation (required) of Gene_expression (production) of C3 in leukocytes associated with arthritis
1) Confidence 0.70 Published 2007 Journal Arthritis and Rheumatism Section Body Doc Link PMC2559465 Disease Relevance 0.33 Pain Relevance 0.16
A requirement for C3 synthesis by radioresistant cells
Positive_regulation (requirement) of Gene_expression (synthesis) of C3
2) Confidence 0.47 Published 2007 Journal Arthritis and Rheumatism Section Body Doc Link PMC2559465 Disease Relevance 0.06 Pain Relevance 0.08
Subsequently, several microarray analyses of synovial gene expression in either human patients or rodent models have yielded conflicting data on this point, sometimes showing an increase in synthesis of C3 (41,42) and sometimes not showing such an increase (43–45).
Positive_regulation (increase) of Gene_expression (synthesis) of C3
3) Confidence 0.41 Published 2007 Journal Arthritis and Rheumatism Section Body Doc Link PMC2559465 Disease Relevance 0.71 Pain Relevance 0.31
Pratt et al. have elegantly demonstrated that intrarenal production of C3 is essential for graft rejection in a renal allograft model 9.
Positive_regulation (essential) of Gene_expression (production) of C3 associated with graft vs host disease
4) Confidence 0.40 Published 2010 Journal European Journal of Immunology Section Body Doc Link PMC2988415 Disease Relevance 0.76 Pain Relevance 0.12
Overexpression of C3 inhibitory soluble complement receptor-related protein inhibited C3 in the brain of an AD mouse model, decreased microglial activation and increased A?
Positive_regulation (Overexpression) of Gene_expression (Overexpression) of C3 in brain associated with disease
5) Confidence 0.30 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2430555 Disease Relevance 1.02 Pain Relevance 0.06
Actually, levels of C3, C8, C9, and FB were all significantly increased in patients 6 and 12 hours after admission for MI (Halas et al 2005).
Positive_regulation (increased) of Gene_expression (levels) of C3 associated with myocardial infarction
6) Confidence 0.20 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727911 Disease Relevance 1.33 Pain Relevance 0.04
Thus, in this model, increased CNS synthesis of C3 precedes senile plaque formation.
Positive_regulation (increased) of Gene_expression (synthesis) of C3 in plaque associated with amyloid plaque
7) Confidence 0.14 Published 2004 Journal J Neuroinflammation Section Body Doc Link PMC529311 Disease Relevance 0.59 Pain Relevance 0.18
Because C3b, an activation protein produced by cleavage of C3, functions as an opsonin [89], the increased C3 levels together with the reduced A?
Positive_regulation (increased) of Gene_expression (levels) of C3 in cleavage
8) Confidence 0.14 Published 2004 Journal J Neuroinflammation Section Body Doc Link PMC529311 Disease Relevance 0.55 Pain Relevance 0.18
Because C3b, an activation protein produced by cleavage of C3, functions as an opsonin [89], the increased C3 levels together with the reduced A?
Positive_regulation (Because) of Gene_expression (levels) of C3 in cleavage
9) Confidence 0.14 Published 2004 Journal J Neuroinflammation Section Body Doc Link PMC529311 Disease Relevance 0.62 Pain Relevance 0.19

General Comments

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