INT179541

Context Info Confidence 0.10 First Reported 2004 Last Reported 2004 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.59 Pain Relevance 0.35

extracellular space (C4b) extracellular region (C4b)

Anatomy Link Frequency hippocampus 2 C4b (Mus musculus)

Pain Link Frequency Relevance Heat Hippocampus 23 98.68 Deafferentation 1 75.52 Somatosensory cortex 1 46.20 cerebral cortex 5 36.20 Inflammation 12 17.12 ischemia 1 14.64 Nerve growth factor 7 5.00 cINOD 4 5.00 amygdala 3 5.00 Inflammatory response 2 5.00

Disease Link Frequency Relevance Heat Disease 90 77.88 Neurodegenerative Disease 2 74.16 Injury 4 70.84 Amyloid Plaque 27 58.36 Drug Induced Neurotoxicity 3 53.84 Death 3 50.00 Gliosis 2 35.84 Fever 2 27.72 INFLAMMATION 16 17.12 Stroke 2 15.88

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Injection of kainic acid similarly increased C1qB and C4 mRNA expression and C1q immunoreactivity in the hippocampus [108,109].

Positive_regulation (increased) of Transcription (expression) of C4 in hippocampus associated with hippocampus

1) Confidence 0.10 Published 2004 Journal J Neuroinflammation Section Body Doc Link PMC529311 Disease Relevance 0.59 Pain Relevance 0.35

General Comments

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