INT179542

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Context Info
Confidence 0.52
First Reported 2004
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 27
Total Number 29
Disease Relevance 19.39
Pain Relevance 3.83

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (C3) extracellular space (C3) extracellular region (C3)
Anatomy Link Frequency
skin 2
neutrophils 2
T cell 2
liver 1
cleavage 1
C3 (Mus musculus)
Pain Link Frequency Relevance Heat
cva 33 99.28 Very High Very High Very High
tolerance 100 99.16 Very High Very High Very High
cytokine 95 97.80 Very High Very High Very High
Inflammation 337 97.68 Very High Very High Very High
rheumatoid arthritis 112 97.08 Very High Very High Very High
Arthritis 158 95.04 Very High Very High Very High
Dysuria 4 93.04 High High
ischemia 55 90.40 High High
Inflammatory response 49 89.64 High High
cerebral cortex 5 85.92 High High
Disease Link Frequency Relevance Heat
Myocardial Infarction 199 100.00 Very High Very High Very High
Injury 264 99.96 Very High Very High Very High
Colon Cancer 1 99.48 Very High Very High Very High
Arthritis 169 99.40 Very High Very High Very High
Asthma 20 99.32 Very High Very High Very High
Cv General 3 Under Development 32 99.28 Very High Very High Very High
Increased Venous Pressure Under Development 23 99.08 Very High Very High Very High
Candida Infection 1 98.90 Very High Very High Very High
Body Weight 38 98.80 Very High Very High Very High
Autoimmune Disease 68 98.60 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
C3 is expressed at similar levels in unwounded PU.1 null and wild-type skin, but whereas expression is rapidly upregulated by 30 minutes post-wounding and continues until 24 hours in wild-type wounds, upregulation of C3 is delayed and much weaker in the PU.1 null wound (Figure 7Ad-f).
Positive_regulation (upregulation) of C3 in skin associated with injury
1) Confidence 0.52 Published 2005 Journal Genome Biol Section Body Doc Link PMC549066 Disease Relevance 1.41 Pain Relevance 0.22
With regard to the complement cascade, factors B, D (Monach PA: unpublished observations), C3, C5, and the receptor for C5a (C5aR) are required, whereas C1q, C4, C6, and the complement receptors CR1, CR2, and CR3 are not (1,19).
Positive_regulation (required) of C3
2) Confidence 0.50 Published 2007 Journal Arthritis and Rheumatism Section Body Doc Link PMC2559465 Disease Relevance 0.66 Pain Relevance 0.35
Biopsy of her skin lesions revealed arteriolar vasculitis with perivascular monocytic infiltrates, and increased C3 and IgM staining.
Positive_regulation (increased) of C3 in skin associated with increased venous pressure under development
3) Confidence 0.46 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2212569 Disease Relevance 0.85 Pain Relevance 0.13
All three pathways activate C3 by forming an enzyme, the C3 convertase, which cleaves C3 generating the C3a anaphylatoxin and the activation product C3b.
Positive_regulation (activate) of C3
4) Confidence 0.46 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2212569 Disease Relevance 1.02 Pain Relevance 0.11
Figure 4Circulating C3 deposition in arthritic joints.
Positive_regulation (4Circulating) of C3 in joints associated with arthritis
5) Confidence 0.44 Published 2007 Journal Arthritis and Rheumatism Section Body Doc Link PMC2559465 Disease Relevance 0.82 Pain Relevance 0.27
In support of the hypothesis that different experimental models underlie the differences, a requirement for C3 in the induction of tolerance has also been reported in some models.
Positive_regulation (requirement) of C3 associated with tolerance
6) Confidence 0.40 Published 2010 Journal European Journal of Immunology Section Body Doc Link PMC2988415 Disease Relevance 0.08 Pain Relevance 0.21
Thus the requirement of C1q and C3 for promoting intranasal tolerance is a new finding with therapeutic potential.
Positive_regulation (requirement) of C3 associated with tolerance
7) Confidence 0.40 Published 2010 Journal European Journal of Immunology Section Body Doc Link PMC2988415 Disease Relevance 0.35 Pain Relevance 0.18
The chemotactic effects of C5a-C5aR ligation then attracts neutrophils to sites of inflammation to produce properdin, which, upon binding to C3b-IgG complexes, enhances the association with factor B, leading to stabilization of the alternative pathway C3 convertase and amplification of the alternative pathway C3 consumption.
Positive_regulation (stabilization) of C3 in neutrophils associated with inflammation
8) Confidence 0.38 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175042 Disease Relevance 0.70 Pain Relevance 0.26
An up-regulation of C3 has been noted in the transplanted rat liver following induction of tolerance 28.
Positive_regulation (regulation) of C3 in liver associated with tolerance
9) Confidence 0.37 Published 2010 Journal European Journal of Immunology Section Body Doc Link PMC2988415 Disease Relevance 0.09 Pain Relevance 0.19
As shown with human C4bp the mouse C4bp binds both mouse C4b in vivo and in vitro [25,27], and mouse C4 is unable to form a functional C3 convertase when bound to C4bp [27].
Neg (unable) Positive_regulation (functional) of C3
10) Confidence 0.33 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2212569 Disease Relevance 0.51 Pain Relevance 0
Functionally, C4bp limits complement activation by blocking the formation of and promoting the decay of the classical pathway C3 convertase.
Positive_regulation (promoting) of C3
11) Confidence 0.33 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2212569 Disease Relevance 0.54 Pain Relevance 0.08
Nevertheless, when related to body weight the specific bone mineral density (sBMD) was significantly increased in C3.Dll1tm1Gos/+ animals (Figure 5B).
Positive_regulation (increased) of C3 in body associated with body weight
12) Confidence 0.29 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2699037 Disease Relevance 0.24 Pain Relevance 0
In clinical studies on TBI patients, we have reported elevated levels of the crucial components required for alternative pathway complement activation, factor B and C3, in the CSF of severely head-injured patients [37].
Positive_regulation (activation) of C3 in head associated with brain injury
13) Confidence 0.29 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1540436 Disease Relevance 0.85 Pain Relevance 0.13
These findings indicate that the C3-sensitive Ca2+ sensitization, probably mediated by RhoA [25,26], might be augmented in BSMs of the OA-challenged AHR mice.


Positive_regulation (augmented) of C3
14) Confidence 0.25 Published 2005 Journal Respir Res Section Body Doc Link PMC545934 Disease Relevance 0 Pain Relevance 0
The systolic, diastolic and mean arterial pressures were significantly elevated in C3.Dll1tm1Gos/+ male mice (Figure 3A–C).
Positive_regulation (elevated) of C3
15) Confidence 0.25 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2699037 Disease Relevance 0.27 Pain Relevance 0
Furthermore, positive correlations have been shown between SF complement activation (for example levels of plasma C3dg, a C3 activation metabolite) and local as well as general disease activity in RA, and between C2 and C3 expression in RA synovium and inflammation [19,20].
Positive_regulation (activation) of C3 in synovium associated with inflammation, rheumatoid arthritis and disease
16) Confidence 0.25 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175042 Disease Relevance 1.45 Pain Relevance 0.49
These findings suggest that the C3-sensitive, RhoA-mediated Ca2+ sensitization might be augmented in BSMs of the OA-challenged AHR mice.
Positive_regulation (mediated) of C3
17) Confidence 0.22 Published 2005 Journal Respir Res Section Body Doc Link PMC545934 Disease Relevance 0.15 Pain Relevance 0
C3 levels were shown to be a strong predictor of MI, especially in men, and C3a levels were elevated in patients with unstable angina as compared to those with stable angina (Muscari et al 1995; Kostner et al 2006).
Positive_regulation (elevated) of C3 associated with cva and myocardial infarction
18) Confidence 0.18 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727911 Disease Relevance 1.69 Pain Relevance 0.18
Actually, levels of C3, C8, C9, and FB were all significantly increased in patients 6 and 12 hours after admission for MI (Halas et al 2005).
Positive_regulation (increased) of C3 associated with myocardial infarction
19) Confidence 0.18 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727911 Disease Relevance 1.33 Pain Relevance 0.04
Finally, C3 and C4 levels in patients admitted for AMI were significantly higher than in patients with stable angina or healthy controls, and the serum C3/C4 ratio could possibly be used as a marker of subsequent cardiovascular events after a previous manifestation of ACS (Iltumur et al 2005; Palikhe et al 2007).
Positive_regulation (used) of C3 associated with acute coronary syndrome, cva and myocardial infarction
20) Confidence 0.17 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727911 Disease Relevance 1.54 Pain Relevance 0.17

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