INT179548

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Context Info
Confidence 0.58
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 17
Total Number 17
Disease Relevance 9.88
Pain Relevance 1.62

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (C4b) extracellular region (C4b)
Anatomy Link Frequency
hippocampus 2
leukocyte 1
aorta 1
cleavage 1
T cell 1
C4b (Mus musculus)
Pain Link Frequency Relevance Heat
chemokine 8 100.00 Very High Very High Very High
Hippocampus 100 98.72 Very High Very High Very High
ischemia 58 98.72 Very High Very High Very High
cva 10 97.64 Very High Very High Very High
TRP channel 50 83.20 Quite High
Inflammation 123 77.32 Quite High
fibrosis 40 76.24 Quite High
Deafferentation 2 67.36 Quite High
gABA 1 64.56 Quite High
Pain 4 49.52 Quite Low
Disease Link Frequency Relevance Heat
Targeted Disruption 114 100.00 Very High Very High Very High
Sprains And Strains 205 99.52 Very High Very High Very High
Colon Cancer 1 99.48 Very High Very High Very High
Myocardial Infarction 49 98.96 Very High Very High Very High
Cv Unclassified Under Development 45 98.72 Very High Very High Very High
Recurrence 2 98.64 Very High Very High Very High
Cv General 3 Under Development 8 97.64 Very High Very High Very High
Cancer 31 96.00 Very High Very High Very High
Disease 362 94.28 High High
Injury 154 92.32 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The biology of C4 and its cleavage products in the mouse is unclear due to a paucity of reagents available for this animal.
Gene_expression (products) of C4 in cleavage
1) Confidence 0.58 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2212569 Disease Relevance 0.32 Pain Relevance 0
It is possible that local production of C4 in the kidney is more responsible for leukocyte accumulation in this than in other organs.
Gene_expression (production) of C4 in leukocyte
2) Confidence 0.58 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2212569 Disease Relevance 0.35 Pain Relevance 0
The C3 and C4 levels in serum were measured by semiquantitative ELISA.
Gene_expression (levels) of C4
3) Confidence 0.57 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2212569 Disease Relevance 0.06 Pain Relevance 0
As the local, nonhepatic, synthesis of C4 is normal in mice with the H-2k allele, a second explanation for the lack of phenotype in C4bp KO MRL mice is that the classical pathway plays only a minor role in local complement-dependent injury in the MRL mouse.
Gene_expression (synthesis) of C4 associated with injury
4) Confidence 0.51 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2212569 Disease Relevance 0.60 Pain Relevance 0
The data indicate that, similar to humans, serum C4 levels rise early in life from 3 weeks to 8 weeks of age.
Gene_expression (levels) of C4
5) Confidence 0.51 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2212569 Disease Relevance 0.61 Pain Relevance 0.03
Although it is possible that the reduced levels of C4 in the MRL strain limit the intrinsic capacity of the classical pathway to generate C3b, there are data to suggest that amplification of C3b generation via the alternative pathway is required for immune complex clearance [50].
Gene_expression (levels) of C4 associated with sprains and strains
6) Confidence 0.51 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2212569 Disease Relevance 0.29 Pain Relevance 0
Of note, the levels of C4 in CTRL MRL mouse serum were 16-fold lower than those measured in wildtype CTRL B6 mice or in KO B6 mice (P < 0.001).
Gene_expression (levels) of C4
7) Confidence 0.51 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2212569 Disease Relevance 0.15 Pain Relevance 0
For C4 staining, FITC-conjugated donkey anti-rat IgG was used for detection of primary antibody after absorbing for 15 min with normal mouse serum (Jackson ImmunoResearch, West Grove, PA, USA).
Gene_expression (staining) of C4
8) Confidence 0.50 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2212569 Disease Relevance 0.61 Pain Relevance 0.18
Of the ten genes assayed, the expression changes for eight genes were confirmed with a change of 1.3-fold or greater: intracisternal-A particles (Iap), upstream transcription factor 1 (Usf1), potassium voltage-gated channel, subfamily Q, member 2 (Kcnq2), chemokine (C-C motif) ligand 19 (Ccl19), erythroid differentiation regulator (edr), caspase 9 (Casp9), chemokine (C-C motif) ligand 27 (Ccl27), complement and component 4 (C4).
Gene_expression (expression) of C4 associated with chemokine
9) Confidence 0.36 Published 2005 Journal Genome Biol Section Body Doc Link PMC1175968 Disease Relevance 0.10 Pain Relevance 0.13
Therefore, we subjected transgenic C4/?
Gene_expression (/) of C4 associated with targeted disruption
10) Confidence 0.25 Published 2007 Journal Brain Pathology (Zurich, Switzerland) Section Body Doc Link PMC1859984 Disease Relevance 0.78 Pain Relevance 0.16
Therefore, we subjected transgenic C4/?
Gene_expression (transgenic) of C4 associated with targeted disruption
11) Confidence 0.25 Published 2007 Journal Brain Pathology (Zurich, Switzerland) Section Body Doc Link PMC1859984 Disease Relevance 0.78 Pain Relevance 0.16
Signals of TRPC1, C3, C4, C5 and C6 have been reported in mouse and rat aorta, while TRPC2 and C7 transcripts were not observed [7].
Gene_expression (Signals) of C4 in aorta
12) Confidence 0.24 Published 2006 Journal BMC Genomics Section Body Doc Link PMC1557673 Disease Relevance 0.09 Pain Relevance 0.08
Moreover, immune parameters specifically related to the age of colorectal cancer patients, such as higher levels of C3, C4 and immunosuppressive acidic protein (IAP), and lower T cell stimulation index could contribute to cancer development and explain why they respond to a lesser extent to adjuvant immunochemotherapy than immunologically intact young subjects (Munemoto et al 2004).
Gene_expression (levels) of C4 in T cell associated with cancer and colon cancer
13) Confidence 0.13 Published 2007 Journal Clinical Interventions in Aging Section Body Doc Link PMC2684090 Disease Relevance 1.11 Pain Relevance 0.03
Colchicine infusion into the dorsal hippocampus, which selectively damages granule cells of the dentate gyrus, produced elevated mRNA expression of hippocampal C1qB and C4 [109].
Gene_expression (produced) of C4 in hippocampus associated with hippocampus
14) Confidence 0.11 Published 2004 Journal J Neuroinflammation Section Body Doc Link PMC529311 Disease Relevance 0.63 Pain Relevance 0.33
Colchicine infusion into the dorsal hippocampus, which selectively damages granule cells of the dentate gyrus, produced elevated mRNA expression of hippocampal C1qB and C4 [109].
Gene_expression (expression) of C4 in hippocampus associated with hippocampus
15) Confidence 0.11 Published 2004 Journal J Neuroinflammation Section Body Doc Link PMC529311 Disease Relevance 0.58 Pain Relevance 0.32
Finally, C3 and C4 levels in patients admitted for AMI were significantly higher than in patients with stable angina or healthy controls, and the serum C3/C4 ratio could possibly be used as a marker of subsequent cardiovascular events after a previous manifestation of ACS (Iltumur et al 2005; Palikhe et al 2007).
Gene_expression (levels) of C4 associated with acute coronary syndrome, cva and myocardial infarction
16) Confidence 0.09 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727911 Disease Relevance 1.66 Pain Relevance 0.18
Laboratory workup revealed mild C4 deficiency and an undetectable IgE level (Table 1).
Gene_expression (deficiency) of C4
17) Confidence 0.05 Published 2010 Journal Clin Mol Allergy Section Body Doc Link PMC2856528 Disease Relevance 1.16 Pain Relevance 0

General Comments

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